Diastereoselective Synthesis of Optically Active C2-Substituted Spiro[4.5]decanes : Two Key Intermediates for Spirovetivane Sesquiterpenes

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概要

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• We investigated the stereoselective construction of the C2 stereogenic center of the spiro[4.5]decane skeleton present in the spirovetivanes, spirolaurane, and spiroaxanes, and succeeded in synthesizing 2α- and 2β-substituted 6-spiro[4.5]decanones with diastereoselectivity by employing n-Bu_3-SnH-mediated spiroannulation of the alkylmercury chloride, and Pd(II)-mediated spiroannulation followed by catalytic hydrogenation of the resulting unsaturated ester, respectively.

• 公益社団法人日本薬学会の論文
• 1997-03-15

著者

• 岩田 宙造

  阪大院薬

• 邑楽 泰一

  Faculty of Pharmaceutical Sciences, Osaka University

• Takemoto Y

  Faculty Of Pharmaceutical Sciences Osaka University

• Takemoto Yoshiji

  Faculty Of Pharmaceutical Sciences Osaka University

• IWATA Chuzo

  Faculty of Pharmaceutical Sciences, Osaka University

• Iwata Chuzo

  Faculty Of Pharmaceutical Sciences Osaka University

• OHRA Taiichi

  Faculty of Pharmaceutical Sciences, Osaka University

• YONETOKU Yasuhiro

  Faculty of Pharmaceutical Sciences, Osaka University

• Ohra T

  Faculty Of Pharmaceutical Sciences Osaka University

• Yonetoku Y

  Yamanouchi Pharmaceutical Co. Ltd. Ibaraki Jpn

• Yonetoku Yasuhiro

  Faculty Of Pharmaceutical Sciences Osaka University

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