Asymmetric Cyclopropanation by Reaction of a γ-Chloromethylated Chiral Vinylic Sulfoxide with Allylmagnesium Bromide

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概要

• 論文の詳細を見る

• An optically active vinylic sulfoxide bearing a leaving group at the γ-position was stereoselectively transformed into a chiral cyclopropane by means of a Michael addition with an allylmagnesium bromide. The Michael induced ring-closure reaction requires both allylmagnesium bromide as a uncleophile and chloride as a leaving group for high diastereoselectivity. The absolute stereochemistry of the cycloadduct was confirmed by X-ray analysis.

• 公益社団法人日本薬学会の論文
• 1995-04-15

著者

• 今西 武

  Faculty Of Pharmaceutical Sciences Osaka University

• 竹本 佳司

  Faculty Of Pharmaceutical Sciences Osaka University

• 岩田 宙造

  Faculty of Pharmaceutical Sciences, Osaka University

• 岩田 宙造

  阪大院薬

• 杉山 憲司

  Faculty Of Pharmaceutical Sciences Osaka University

• 邑楽 泰一

  Faculty of Pharmaceutical Sciences, Osaka University

• Takemoto Yoshiji

  Faculty Of Pharmaceutical Sciences Osaka University

• Takemoto Y

  Graduate School Of Pharmaceutical Sciences Kyoto University

• 岩田 宙造

  Faculty Of Pharmaceutical Sciences Osaka University

• Ohra T

  Faculty Of Pharmaceutical Sciences Osaka University

• 邑楽 泰一

  Faculty Of Pharmaceutical Sciences Osaka University

• Kubo S

  Department Of Pharmacology Niigata College Of Pharmacy

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