Total Synthesis of (±)-Solavetivone and Aglycone A_3. Regio-and Stereo-Selective Birch Reduction of 6,10-Dimethyl-2-hydroxy-spiro[4.5]deca-6,9-dien-8-one(Organic,Chemical)

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概要

• 論文の詳細を見る

• Total synthesis of (±)-solavetivone (1), a spirovetivane phytoalexin, was achieved. The metal catalyzed decomposition of the phenolic diazoketone (8) gave the spiro-dienone (6), selective reduction of which afforded the hydroxy-enone (5). The regie-and stereo-selective Birch reduction of 5 provided a high yield of the hydroxy-spiro-enone (9), whose structure was determined by X-ray crystal analysis. Compound 9 was transformed to (±)-1 and the aglycone A_3 in several steps.

• 公益社団法人日本薬学会の論文
• 1987-02-25

著者

• 山田 稔

  Faculty Of Pharmaceutical Sciences Osaka University

• 冨田 研一

  Faculty of Pharmaceutical Sciences, Osaka University

• 田中 徹明

  Faculty of Pharmaceutical Sciences, Osaka University

• 岩田 宙造

  Faculty of Pharmaceutical Sciences, Osaka University

• 藤原 隆二

  Faculty of Pharmaceutical Sciences, Osaka University

• 田中 徹明

  Faculty Of Pharmaceutical Sciences Osaka University

• 中村 文胤

  日本新薬(株)知的財産部調査課

• 宮下 和之

  Faculty of Pharmaceutical Sciences, Osaka University

• 岩田 宙造

  Faculty Of Pharmaceutical Sciences Osaka University

• 藤原 隆二

  Faculty Of Pharmaceutical Sciences Osaka University

• 冨田 研一

  Faculty Of Pharmaceutical Sciences Osaka University

• 符阪 隆文

  Faculty of Pharmaceutical Sciences, Osaka University

• 中村 文胤

  Faculty of Pharmaceutical Sciences, Osaka University

• 中村 文胤

  田辺製薬 研究企画部

• 中村 文胤

  Faculty Of Pharmaceutical Sciences Osaka University

• 中村 文胤

  日本新薬(株)創薬研究所

• 符阪 隆文

  Faculty Of Pharmaceutical Sciences Osaka University

• 冨田 研一

  大阪大 薬

• 宮下 和之

  Faculty Of Pharmaceutical Sciences Osaka University

• 山田 稔

  Faculty of Pharmaceutical Sciences, Osaka University

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