The Crystal Structure of Carteolol Hydrochloride : 5-(3-tert-Butylamino-2-hydroxy) propoxy-3,4-dihydro-2-quinolone, OPC-1085

スポンサーリンク

概要

• 論文の詳細を見る

• The crystal structure of carteolol hydrochloride (C_<16>H_<24>N_2O_3・HCl), a novel β-adrenergic blocking agent, was determined by X-ray diffraction analysis. The crystal is monoclinic and the space group is P 2_1/n with Z=4. The cell dimensions are a=7.873 (4), b=26.435 (19), c=8.549 (7) A, and β=105.67 (6)°. The structure was solved by a direct method using the MULTAN program and refined by a block-diagonal least-squares method to give a final R-value of 0.054. Cl- anion forms two hydrogen bonds with the cationic amino group and one with the hydroxy group. The amino and hydroxy groups are relatively close together, but no intramolecular hydrogen bond is formed. The C (3)-C (4) bond distance of the 3,4-dihydro-2-quinolone ring, 1.397 A, is rather shorter than a normal single bond distance but it seems probable that the bond is actually single and that the C (3) and C (4) atoms deviate from the least-squares ring plane by 0.42 A and 0.30 A, respectively, to opposite sides.

• 社団法人日本薬学会の論文
• 1981-08-25

著者

• 冨田 研一

  Faculty of Pharmaceutical Sciences, Osaka University

• 木戸 勝

  Tokushima Research Institute, Otsuka Pharmaceutical Co., Ltd.,

• 木戸 勝

  Second Institute Of New Drug Research Otsuka Pharmaceutical Co. Ltd.

• 木戸 勝

  Tokushima Research Institute Otsuka Pharmaceutical Co. Ltd.

• 中川 量之

  2nd Tokushima Institute Of New Drugs Research Otsuka Pharmaceutical Co. Ltd.

• 中川 量之

  大塚製薬株式会社有機化学研究所

• 中川 量之

  Tokushima Research Institute Otsuka Pharmaceutical Co. Ltd.

• 中川 量之

  大塚製薬株式会社徳島研究所

• 藤原 隆二

  Faculty of Pharmaceutical Sciences, Osaka University

• 藤原 隆二

  Faculty Of Pharmaceutical Sciences Osaka University

• 冨田 研一

  Faculty Of Pharmaceutical Sciences Osaka University

• Kido Masaru

  Second Institute Of New Drug Research Otsuka Pharmaceutical Co. Ltd.

関連論文

• Activity of Artificial Mutant Variants of Human Growth Hormone Changes in Charged Residues around 62-67
• Structure of an Anti-plasmin Inhibitor, Eckol, Isolated from the Brown Alga Ecklonia kurome OKAMURA and Inhibitory Activities of Its Derivatives on Plasma Plasmin Inhibitors
• 17 クロメのplasmin inhibitors阻害物質ポリヒドロキシジベンゾ-p-ジオキシン
• Studies on Antibacterial Agents. II. : Synthesis and Antibacterial Activities of Substituted 1,2-Dihydro-6-oxo-6H-pyrrolo[3,2,1-ij]quinoline-5-carboxylic Acids
• Studies on Antibacterial Agents. I. : Synthesis of Substituted 6,7-Dihydro-1-oxo-1H, 5H, -benzo{i, j]-quinolizine-2-carboxylic Acids
• Novel Molecular Conformation of (R, S)-Hesperetin in Anhydrous Crystal
• Studies on Antibacterial Agents. III. : Synthesis and Antibacterial Activities of Substituted 1,4-Dihydro-8-methyl-4-oxoquinoline-3-carboxylic Acids
• Studies on 2(1H)-Quinolinone Derivatives as Neuroleptic Agents. I. : Synthesis and Biological Activities of (4-Phenyl-1-piperazinyl)-propoxy-2(1H)-quinolinone Derivatives
• Studies on Positive Inotropic Agents. VI. : Synthesis of 1-Aromatic Ring Substituted 4-(3,4-Dimethoxybenzoyl)-piperazine Derivatives
• Studies on Positive Inotropic Agents. V. : Synthesis of 1-Heteroaroylpiperazine Derivatives
• 陽性変力作用薬の研究(第3報)6-(Substituted 1-oxoalkyl)-2(1H)quinolinone誘導体の合成
• Studies on Positive Inotropic Agents. II. : Synthesis of(4-Substituted 1-piperazinylcarbonyl)-2-(1H)-quinolinone Derivatives
• Studies on Positive Inotropic Agents. I. Synthesis of 3,4-Dihydro-6-[4-(3,4-dimethoxybenzoyl)-1-piperazinyl]-2 (1H)-quinolinone and Related Compounds
• The Crystal Structures of 5-Hydroxy-3,4-dihydro-2-quinolone and 5-Hydroxy-1-methyl-3,4-dihydro-2-quinolone
• The Crystal Structures of 2-Quinolone and 8-Acetoxy-2-quinolone
• The Molecular Structure of Procaterol Hydrochloride Hemihydrate [5-(1-Hydroxy-2-isopropylaminobutyl)-8-hydroxy-2-quinolone Hydrochloride Hemihydrate, OPC-2009]
• Syntheses and β-Adrenergic Blocking Activities of Carbostyril Derivatives
• Synthesis of 5,8-Dihydroxy-3,4-dihydrocarbostyril
• The Crystal Structure of Carteolol Hydrochloride : 5-(3-tert-Butylamino-2-hydroxy) propoxy-3,4-dihydro-2-quinolone, OPC-1085
• 新β-遮断薬Carteolol Hydrochloride[5-(3-tert-butylamion-2-hydroxypropoxy)-3,4-dihydrocarbostyril Hydrochloride, OPC-1085]の生体内運命(第5報)ラット, イヌおよびヒトにおける代謝産物の同定
• 5-(3-tert-Butylamino-2-hydroxypropoxy)-3,4-dihydrocarbostyril Hydrochloride(OPC-1085)のけい光定量とけい光体の構造について
• 5-(3-tert-Butylamino-2-hydroxypropoxy)-8-hydroxy-3,4-dihydrocarbostyril Hydrochlorideの合成とそのβ-遮断作用について
• 光学活性5-(3-tert-Butylamino-2-hydroxypropoxy)-3,4-dihydrocarbostyril Hydrochlorideの合成とそのβ-遮断作用について
• (3-Amino-2-hydroxy)propoxy-3,4-dihydrocarbostyril誘導体の麻酔犬におけるβ-受容体遮断作用
• Molecular Dynamics and Free Energy Perturbation Calculations on the Mutation of Tyrosine 45 to Tryptophan in Ribonuclease T_1
• Synthesis and Properties of d(ATACGCGTAT) and Its Derivatives Containing One and Two 5-Methylcytosine Residues. : Effect of the Methylation on Deoxyribonucleic Acid Conformation
• Phytochemical Studies on Meliaceous Plants. VII. The Structures of Two New Ionone Glucosides from Melia toosendan SIEB. et ZUCC. and a Novel Type of Selective Biooxidation by a Kind of Protease
• Further Studies on the Reaction of Guanosine Derivatives with Phosphorus Trichloride
• Synthetic Studies on Cephalotaxus Alkaloids. A Synthesis of (±)-Cephalotaxine
• A Convenient Synthesis of 1,3,4,5,-Tetrahydro-2H-3-benzazepin-2-ones by Acid-Catalyzed Cylization of N-(2-Arylethyl)-N-methyl-2-sulfinylacetamides
• Photochemistry of 2-(N-Acyl-N-alkylamino)cyclohex-2-enones : Formation of Spiro-β-lactams(Organic,Chemical)
• Synthesis of 2(1H)-Quinolinone Derivatives and Their Inhibitory Activity on the Release of 12(S)-Hydroxyeicosatetraenoic Acid (12-HETE) from Platelets
• Studies on Gastric Antiulcer Active Agents. III. : Synthesis of 1-Substituted 4-(5-Tetrazolyl)thio-1-butanones and Related Compounds
• Studies on Gastric Antiulcer Active Agents. II. : Synthesis of Tetrazole Alkanamides and Related Compounds
• Studies on 2(1H)-Quinolinone Derivatives as Gastric Antiulcer Active Agents. Synthesis and Antiulcer Activities of Optically Active α-Amino Acid Derivatives of 2(1H)-Quinolinone and Oxindole(Medicinal Chemistry,Chemical)
• Studies on 2(1H)-Quinolinone Derivatives as Gastric Antiulcer Active Agents. Synthesis and Antiulcer Activity of the Metabolites of 2-(4-Chlorobenzoylamino)-3-[2(1H)-quinolinon-4-yl]propionic Acid
• 3-芳香環置換2-(4-Chlorobenzoylamino)propionic Acid誘導体の合成と抗潰瘍作用について
• Studies on 2 (1H)-Quinolinone Derivatives as Gastric Antiulcer Active Agents. 2-(4-Chlorobenzoylamino)-3-[2 (1H)-quinolinon-4-yl] propionic Acid and Related Compounds
• Synthesis and Antiulcer Activity of 4-Substituted 8-[(2-Benzimidazolyl)sulfinylmethyl]-1,2,3,4-tetra-hydroquinolines and Related Compounds
• Studies on Proton Pump Inhibitors. III. : Synthesis of 8-[(2-Benzimidazolyl)sulfinylmethyl]-1,2-dihydroquinolines and Related Compounds
• Studies on Proton Pump Inhibitors. II. : Synthesis and Antiulcer Activity of 8-[(2-Benzimidazolyl)-sulfinylmethyl]-1,2,3,4-tetrahydroquinolines and Related Compounds
• Studies on Proton Pump Inhibitors. I. : Synthesis of 8-[(2-Benzimidazoly)sulfinyl]-5,6,7,8-tetrahydroquinolines and Related Compounds
• STRUCTURES OF MAGNOLOSIDES B AND C. NOVEL PHENYLPROPANOID GLYCOSIDES WITH ALLOPYRANOSE AS CORE THE SUGAR UNIT
• NaBN_4-NiCl_2による除草剤Diquatの還元 : 二種の立体異性体Perhydro-8a, 10a-diazaphenanthreneの構造について
• 61 海藻の抗微生物活性成分
• A Stacking Interaction between Thymine and Phenyl Rings : Crystal Structure of 3'-O-Benzoylthymidine Monohydrate
• Studies on 2-Oxoquinoline Derivatives as Blood Platelet Aggregation Inhibitors. I. Alkyl 4-(2-Oxo-1,2,3,4-tetrahydro-6-quinolyloxy) butyrates and Related Compounds
• P-27 生薬白及の成分に関する研究(ポスター発表の部)
• Studies on 2-Oxoquinoline Derivatives as Blood Platelet Aggregation Inhibitors. IV. Synthesis and Biological Activity of the Metabolites of 6-[4-(1-Cyclohexyl-1H-5-tetrazolyl) butoxy]-2-oxo-1,2,3,4-tetrahydroquinoline (OPC-13013)
• 5-(3-Aryloxypropyl)-1-cyclohexyltetrazole類の合成と血小板凝集抑制作用について
• Studies on 2-Oxoquinoline Derivatives as Blood Platelet Aggregation Inhibitors. II. 6-[3-(1-Cyclohexyl-5-tetrazolyl) propoxy]-1,2-dihydro-2-oxoquinoline and Related Compounds
• Studies on 2-Oxoquinoline Derivatives as Blood Platelet Aggregation Inhibitors. III. N-Cyclohexyl-N-(2-hydroxyethyl)-4-(1,2-dihydro-2-oxo-6-quinolyloxy)-butyramide and Related Compounds
• 30 沖縄サンゴ礁生物Clavularia属軟サンゴ2種の成分研究
• Marine Natural Products. XII. On the Chemical Constituents of the Okinawan Marine Sponge Hymeniacidon aldis
• CLAVUKERIN A, A NEW TRINOR-GUAIANE SESQUITERPENE FROM THE OKINAWAN SOFT CORAL CLAVULARIA KOELLIKERI
• THREE NEW ent-VALERENANE SESQUITERPENES FROM AN OKINAWAN SOFT CORAL
• Absolute Structure of Ionol Glucoside : A Single-Crystal X-Ray Analysis of Dendranthemoside A Pentaacetate
• Conformation and Absolute Sterochemistry of Macrocalyxoformin D (=Longirabdiol)
• 46 Zeorinの構造について
• Molecular Conformations of Carbon-Bridged Cyclodeoxyadenosines in the Solid State and in Solution.2'-Deoxy-8,2'-methanoadenosine and 2'-Deoxy-8,2'-ethanoadenosine
• Crystal and Molecular Structures of Carbon-Bridged Pyrimidine Cyclonucleosides. Substrate Analogs of Ribonuclease A
• A Practical Synthesis of (S)-(-)-Nadifloxacin : Novel Acid-Catalyzed Racemization of Tetrahydroquinaldine Derivative
• Synthesis of 5-Fluorouracil Derivatives Containing an Inhibitor of 5-Fluorouracil Degradation
• β-受容体遮断作用を有する8-アシルアミノ-3,4-ジヒドロカルボスチリル誘導体の合成
• Stichlorogenol and Dehydrostichlorogenol, Genuine Aglycones of Stichlorosides A_1,B_1,C_1 and A_2,B_2,C_2,from the Sea Cucumber Stichopus Chloronotus (BRANDT)
• 426. 有機錫・鉛化合物の構造と抗菌力の関連性 : 多変量解析法の適用
• Synthesis and Absolute Configuration of the Enantiomers of 7-Fluoro-1-methyl-3-(methylsulfinyl)-4(1H)-quinolinone (Flosequinan)
• CORRECT MOLECULAR STRUCTURE OF THE PRODUCT OBTAINED FROM THE REACTION OF ACETYLSALICYLOYLCHLORIDE WITH N-PHENYLHYDROXYLAMINE. ELECTROCHEMICAL AND X-RAY CRYSTALLOGRAPHIC STUDIES
• The Absolute Configuration of (R)-(+)-Nadifloxacin
• Crystal Structures of Nadifloxacin Anhydride and Its Hemihydrate
• X-Ray Structures of Two Photodimers of 2-Methyl-1,4-naphthoquinone (Menadione)
• Intramolecular [2+2] Photocycloaddition of 2-[N-Acyl-N-(2-propenyl)-amino] cyclohex-2-enones : Synthesis of 2-Azabicyclo [2.1.1] hexanes
• INTRAMOLECULAR PHOTO [2+2] CYCLOADDITION OF 2-ALLYLOXY-AND 2-ALLYLAMINOCYCLOHEX-2-ENONES : FORMATION OF 2-OXA-AND 2-AZA-BICYCLO [2.1.1] HEXANE SYSTEMS
• 抗血小板剤シロスタゾールの研究開発
• 生体試料の前処理法として水系ゲルろ過カラムを接続したクロマトグラフィー
• REVISED STRUCTURES OF SOYASAPOGENOLS A, B, AND E, OLEANENE-SAPOGENOLS FROM SOYBEAN. STRUCTURES OF SOYASAPONINS I, II, AND III
• 38 スピロベチバン類の合成研究
• Retinoids and Related Compounds. XI. : Synthesis and Stereochemistry of (±)-C_-Acetylenic and Allenic Apocarotenals
• Total Synthesis of (±)-Solavetivone and Aglycone A_3. Regio-and Stereo-Selective Birch Reduction of 6,10-Dimethyl-2-hydroxy-spiro[4.5]deca-6,9-dien-8-one(Organic,Chemical)
• Glochidionolactones A-F : Butenolide Glucosides from Leaves of Glochidion zeylanicum (GAERTN) A. JUSS
• A Novel Dimeric Butenolide, Glochidiolide, from the Leaves of Glochidion Acuminatum MUELL
• Structure of Rutin Pentamethanol
• 新しい型のβ-シクロデキストリン-水複合体の結晶構造とβ-シクロデキストリン包接化合物の熱的挙動 (「包接現象の化学」)
• 15 13-Acetyl-8-p-bromobenzoyl serratinineの結晶構造
• STABILITY CONSTANTS OF (RS)-1-ISOPROPYL CITRATE METAL COMPLEXES AND PHASE TRANSITION OF ZINC (RS)-1-ISOPROPYL CITRATE

もっと見る 閉じる

スポンサーリンク