X-Ray Structures of Two Photodimers of 2-Methyl-1,4-naphthoquinone (Menadione)

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概要

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• The structures of the photodimers (I) and (II) of menadione (2-methyl-1,4-naphthoquinone, MNQ) were determined by X-ray analysis. It was confirmed that both dimers are structural isomers of the cis-syn and cis-anti forms, i.e., 5a, 5b-cis-dimethyl (I) and 5a, 11a-cis-dimethyl (II) isomers of 5a, 5b, 11a, 11b-tetrahydro-β, β'-cis-binaphthylene-5,6,11,12-tetrone. The dimer (II), which was twisted around the cyclobutane ring, was more deformed than the dimer (I). MM2 calculation indicated that such twisting decreases the steric energy of the dimer (II) more than that of the dimer (I).

• 公益社団法人日本薬学会の論文
• 1993-12-15

著者

• 木戸 勝

  Second Institute Of New Drug Research Otsuka Pharmaceutical Co. Ltd.

• 平良 全栄

  Faculty of Pharmaceutical Sciences, Tokushima Bunri University

• 田中 正己

  徳島文理大学薬学部

• 朝日 豊

  徳島文理大学薬学部

• 平良 全栄

  Faculty Of Pharmaceutical Sciences Tokushima Bunri University

• 木戸 勝

  Institute of Tokushima, Otsuka Pharmaceutical Co., Ltd.,

• 田中 正己

  Faculty of Pharmaceutical Sciences, Tokushima Bunri University

• 朝日 豊

  Faculty of Pharmaceutical Sciences, Tokushima Bunri University

• Kido Masaru

  Second Institute Of New Drug Research Otsuka Pharmaceutical Co. Ltd.

• 朝日 豊

  Faculty Of Pharmaceutical Sciences Tokushima Bunri University

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