Interaction between Drugs and Water-Soluble Polymers. I. : Binding of Warfarin and 4-Hydroxycoumarin with Polyvinylpyrrolidone and Acrylamide-Vinylpyrrolidone Copolymer

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The interaction between drugs and water-soluble polymers was studied by an equilibrium dialysis method. Drugs used were warfarin (WF) and 4-hydroxycoumarin (HC). Polymers used were polyvinylpyrrolidone (PVP), polyacrylamide (PAA), acrylamide-vinylpyrrolidone copolymer (CAV), dextran (DX) and bovine serum albumin (BSA). No interaction of the drugs with PAA or DX was observed. The bindings of drugs with PVP and CAV were predominantly attributed to hydrophobic interaction, and the polymers had a large number of bindings sites (n). BSA exhibited a specific hydrophobic interaction with the drugs at two binding sites. The standard increase of enthalpy (ΔH°) was estimated to be 16-20 kJ/mol from the temperature dependence of the binding constant. Phenylbutazone (PB) competed with WF for the binding to BSA, CAV and PVP.
公益社団法人日本薬学会の論文
1988-12-25