Studies on 2-Oxoquinoline Derivatives as Blood Platelet Aggregation Inhibitors. I. Alkyl 4-(2-Oxo-1,2,3,4-tetrahydro-6-quinolyloxy) butyrates and Related Compounds

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概要

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• Many alkyl 4-(2-oxo-1,2,3,4-tetrahydro-6-quinolyloxy) butyrates and related compounds were synthesized and tested for inhibitory activity against blood platelet aggregation in vitro. Among them, ethyl 4-(2-oxo-1,2,3,4-tetrahydro-6-quinolyloxy) butyrate was found to have the most potent inhibitory activity. The structure-activity relationships are discussed.

• 社団法人日本薬学会の論文
• 1983-03-25

著者

• 清水 剛文

  Tokushima Research Institute Otsuka Pharmaceutical Co. Ltd.

• 中川 量之

  2nd Tokushima Institute Of New Drugs Research Otsuka Pharmaceutical Co. Ltd.

• 中川 量之

  大塚製薬株式会社有機化学研究所

• 中川 量之

  大塚製薬株式会社徳島研究所

• 山本 活義

  Tokushima Research Institute Otsuka Pharmaceutical Co. Ltd.

• 西 孝夫

  大塚製薬株式会社徳島第2工場医薬生産部

• 神辺 敏実

  Tokushima Research Institute, Otsuka Pharmaceutical Co., Ltd.,

• 西 孝夫

  Tokushima Research Institute, Otsuka Pharmaceutical Co., Ltd.

• 木村 征夫

  Tokushima Research Institute, Otsuka Pharmaceutical Co., Ltd.

• 神辺 敏実

  Tokushima Research Institute Otsuka Pharmaceutical Co. Ltd.

• 木村 征夫

  大塚製薬株式会社医薬第一研究所

• 清水 剛文

  Tokushima Research Institute, Otsuka Pharmaceutical Co., Ltd.,

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