Studies on 2-Oxoquinoline Derivatives as Blood Platelet Aggregation Inhibitors. II. 6-[3-(1-Cyclohexyl-5-tetrazolyl) propoxy]-1,2-dihydro-2-oxoquinoline and Related Compounds

スポンサーリンク

概要

• 論文の詳細を見る

• A series of ω-(1-substituted-5-tetrazolylalkoxy)-2-oxoquinolines was synthesized and tested for inhibitory activity towards collagen-and adenosine diphosphate (ADP)-induced aggregation of rabbit blood platelets in vitro. These compounds were prepared by the reaction of 1-substituted-5-(ω-chloroalkyl)-tetrazoles and hydroxy-2-oxoquinolines in the presence of a base. Among them, 6-[3-(1-cyclohexyl-5-tetrazolyl)propoxy]-1,2-dihydro-2-oxoquinoline (IVb) was found to have the most potent inhibitory activity. The structure-activity relationships are discussed.

• 社団法人日本薬学会の論文
• 1983-04-25

著者

• 清水 剛文

  Tokushima Research Institute Otsuka Pharmaceutical Co. Ltd.

• 田房 不二男

  2nd Tokushima Institute Of New Drugs Research Otsuka Pharmaceutical Co. Ltd.

• 中川 量之

  2nd Tokushima Institute Of New Drugs Research Otsuka Pharmaceutical Co. Ltd.

• 中川 量之

  大塚製薬株式会社有機化学研究所

• 中川 量之

  Tokushima Research Institute Otsuka Pharmaceutical Co. Ltd.

• 中川 量之

  大塚製薬株式会社徳島研究所

• 西 孝夫

  大塚製薬株式会社徳島第2工場医薬生産部

• 神辺 敏実

  Tokushima Research Institute, Otsuka Pharmaceutical Co., Ltd.,

• 田房 不二男

  Tokushima Research Institute, Otsuka Pharmaceutical Co., Ltd.

• 西 孝夫

  Tokushima Research Institute, Otsuka Pharmaceutical Co., Ltd.

• 木村 征夫

  Tokushima Research Institute, Otsuka Pharmaceutical Co., Ltd.

• 田中 達義

  Tokushima Research Institute, Otsuka Pharmaceutical Co., Ltd.

• 神辺 敏実

  Tokushima Research Institute Otsuka Pharmaceutical Co. Ltd.

• 木村 征夫

  大塚製薬株式会社医薬第一研究所

• 田中 達義

  Tokushima Research Institute Otsuka Pharmaceutical Co. Ltd.

• 清水 剛文

  Tokushima Research Institute, Otsuka Pharmaceutical Co., Ltd.,

関連論文

• Studies on Antibacterial Agents. II. : Synthesis and Antibacterial Activities of Substituted 1,2-Dihydro-6-oxo-6H-pyrrolo[3,2,1-ij]quinoline-5-carboxylic Acids
• Studies on Antibacterial Agents. I. : Synthesis of Substituted 6,7-Dihydro-1-oxo-1H, 5H, -benzo{i, j]-quinolizine-2-carboxylic Acids
• Studies on Antibacterial Agents. III. : Synthesis and Antibacterial Activities of Substituted 1,4-Dihydro-8-methyl-4-oxoquinoline-3-carboxylic Acids
• Studies on 2(1H)-Quinolinone Derivatives as Neuroleptic Agents. I. : Synthesis and Biological Activities of (4-Phenyl-1-piperazinyl)-propoxy-2(1H)-quinolinone Derivatives
• Studies on Positive Inotropic Agents. VI. : Synthesis of 1-Aromatic Ring Substituted 4-(3,4-Dimethoxybenzoyl)-piperazine Derivatives
• Studies on Positive Inotropic Agents. V. : Synthesis of 1-Heteroaroylpiperazine Derivatives
• 陽性変力作用薬の研究(第3報)6-(Substituted 1-oxoalkyl)-2(1H)quinolinone誘導体の合成
• Studies on Positive Inotropic Agents. II. : Synthesis of(4-Substituted 1-piperazinylcarbonyl)-2-(1H)-quinolinone Derivatives
• Studies on Positive Inotropic Agents. I. Synthesis of 3,4-Dihydro-6-[4-(3,4-dimethoxybenzoyl)-1-piperazinyl]-2 (1H)-quinolinone and Related Compounds
• The Crystal Structures of 5-Hydroxy-3,4-dihydro-2-quinolone and 5-Hydroxy-1-methyl-3,4-dihydro-2-quinolone
• The Crystal Structures of 2-Quinolone and 8-Acetoxy-2-quinolone
• The Molecular Structure of Procaterol Hydrochloride Hemihydrate [5-(1-Hydroxy-2-isopropylaminobutyl)-8-hydroxy-2-quinolone Hydrochloride Hemihydrate, OPC-2009]
• Syntheses and β-Adrenergic Blocking Activities of Carbostyril Derivatives
• Synthesis of 5,8-Dihydroxy-3,4-dihydrocarbostyril
• The Crystal Structure of Carteolol Hydrochloride : 5-(3-tert-Butylamino-2-hydroxy) propoxy-3,4-dihydro-2-quinolone, OPC-1085
• 新β-遮断薬Carteolol Hydrochloride[5-(3-tert-butylamion-2-hydroxypropoxy)-3,4-dihydrocarbostyril Hydrochloride, OPC-1085]の生体内運命(第5報)ラット, イヌおよびヒトにおける代謝産物の同定
• 5-(3-tert-Butylamino-2-hydroxypropoxy)-3,4-dihydrocarbostyril Hydrochloride(OPC-1085)のけい光定量とけい光体の構造について
• 5-(3-tert-Butylamino-2-hydroxypropoxy)-8-hydroxy-3,4-dihydrocarbostyril Hydrochlorideの合成とそのβ-遮断作用について
• 光学活性5-(3-tert-Butylamino-2-hydroxypropoxy)-3,4-dihydrocarbostyril Hydrochlorideの合成とそのβ-遮断作用について
• (3-Amino-2-hydroxy)propoxy-3,4-dihydrocarbostyril誘導体の麻酔犬におけるβ-受容体遮断作用
• Studies on Gastric Antiulcer Active Agents. III. : Synthesis of 1-Substituted 4-(5-Tetrazolyl)thio-1-butanones and Related Compounds
• Studies on Gastric Antiulcer Active Agents. II. : Synthesis of Tetrazole Alkanamides and Related Compounds
• Studies on 2(1H)-Quinolinone Derivatives as Gastric Antiulcer Active Agents. Synthesis and Antiulcer Activities of Optically Active α-Amino Acid Derivatives of 2(1H)-Quinolinone and Oxindole(Medicinal Chemistry,Chemical)
• Studies on 2(1H)-Quinolinone Derivatives as Gastric Antiulcer Active Agents. Synthesis and Antiulcer Activity of the Metabolites of 2-(4-Chlorobenzoylamino)-3-[2(1H)-quinolinon-4-yl]propionic Acid
• 3-芳香環置換2-(4-Chlorobenzoylamino)propionic Acid誘導体の合成と抗潰瘍作用について
• Studies on 2 (1H)-Quinolinone Derivatives as Gastric Antiulcer Active Agents. 2-(4-Chlorobenzoylamino)-3-[2 (1H)-quinolinon-4-yl] propionic Acid and Related Compounds
• Synthesis and Antiulcer Activity of Optical Isomers of 2-(4-Chlorobenzoylamino)-3-[2(1H)-quinolinon-4-yl]propionic Acid (Rebamipide)
• Synthesis and Antiulcer Activity of 4-Substituted 8-[(2-Benzimidazolyl)sulfinylmethyl]-1,2,3,4-tetra-hydroquinolines and Related Compounds
• Studies on Proton Pump Inhibitors. III. : Synthesis of 8-[(2-Benzimidazolyl)sulfinylmethyl]-1,2-dihydroquinolines and Related Compounds
• Studies on Proton Pump Inhibitors. II. : Synthesis and Antiulcer Activity of 8-[(2-Benzimidazolyl)-sulfinylmethyl]-1,2,3,4-tetrahydroquinolines and Related Compounds
• Studies on Proton Pump Inhibitors. I. : Synthesis of 8-[(2-Benzimidazoly)sulfinyl]-5,6,7,8-tetrahydroquinolines and Related Compounds
• STRUCTURES OF MAGNOLOSIDES B AND C. NOVEL PHENYLPROPANOID GLYCOSIDES WITH ALLOPYRANOSE AS CORE THE SUGAR UNIT
• Studies on 2-Oxoquinoline Derivatives as Blood Platelet Aggregation Inhibitors. I. Alkyl 4-(2-Oxo-1,2,3,4-tetrahydro-6-quinolyloxy) butyrates and Related Compounds
• Synthesis and Antibacterial Activity of the Metabolites of 9-Fluoro-6,7-dihydro-8-(4-hydroxy-1-piperidyl)-5-methyl-1-oxo-1H, 5H-benzo[i, j]quinolizine-2-carboxylic Acid (OPC-7251)
• Studies on 2-Oxoquinoline Derivatives as Blood Platelet Aggregation Inhibitors. IV. Synthesis and Biological Activity of the Metabolites of 6-[4-(1-Cyclohexyl-1H-5-tetrazolyl) butoxy]-2-oxo-1,2,3,4-tetrahydroquinoline (OPC-13013)
• 5-(3-Aryloxypropyl)-1-cyclohexyltetrazole類の合成と血小板凝集抑制作用について
• Studies on 2-Oxoquinoline Derivatives as Blood Platelet Aggregation Inhibitors. II. 6-[3-(1-Cyclohexyl-5-tetrazolyl) propoxy]-1,2-dihydro-2-oxoquinoline and Related Compounds
• Studies on 2-Oxoquinoline Derivatives as Blood Platelet Aggregation Inhibitors. III. N-Cyclohexyl-N-(2-hydroxyethyl)-4-(1,2-dihydro-2-oxo-6-quinolyloxy)-butyramide and Related Compounds
• β-受容体遮断作用を有する8-アシルアミノ-3,4-ジヒドロカルボスチリル誘導体の合成
• Synthesis and Absolute Configuration of the Enantiomers of 7-Fluoro-1-methyl-3-(methylsulfinyl)-4(1H)-quinolinone (Flosequinan)
• 抗血小板剤シロスタゾールの研究開発
• 抗血小板剤シロスタゾール(プレタール^)の研究開発
• 生体試料の前処理法として水系ゲルろ過カラムを接続したクロマトグラフィー

もっと見る 閉じる

スポンサーリンク