Studies on 2-Oxoquinoline Derivatives as Blood Platelet Aggregation Inhibitors. IV. Synthesis and Biological Activity of the Metabolites of 6-[4-(1-Cyclohexyl-1H-5-tetrazolyl) butoxy]-2-oxo-1,2,3,4-tetrahydroquinoline (OPC-13013)

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概要

• 論文の詳細を見る

• The metabolites of 6-[4-(1-cyclohexyl-1H-5-tetrazolyl) butoxy]-2-oxo-1,2,3,4-tetrahydroquinoline (OPC-13013) (1), which has a potent inhibitory activity toward blood platelet aggregation and a cerebral vasodilating activity, were synthesized to confirm their structures and to examine their inhibitory activity. The structures of four major metabolites (2a-c and 3) and a specific metabolite (4) found only in man were identified unequivocally by means of comparisons with the synthetic compounds. The inhibitory activity of 3,4-dehydro-OPC-13013 (3) was about three times higher than that of 1,whereas two metabolites (2a and 2c) had activity almost equal to that of 1.

• 社団法人日本薬学会の論文
• 1985-03-25

著者

• 清水 剛文

  Tokushima Research Institute Otsuka Pharmaceutical Co. Ltd.

• 田房 不二男

  2nd Tokushima Institute Of New Drugs Research Otsuka Pharmaceutical Co. Ltd.

• 中川 量之

  2nd Tokushima Institute Of New Drugs Research Otsuka Pharmaceutical Co. Ltd.

• 中川 量之

  大塚製薬株式会社有機化学研究所

• 中川 量之

  Tokushima Research Institute Otsuka Pharmaceutical Co. Ltd.

• 中川 量之

  大塚製薬株式会社徳島研究所

• 西 孝夫

  大塚製薬株式会社徳島第2工場医薬生産部

• 田房 不二男

  Tokushima Research Institute, Otsuka Pharmaceutical Co., Ltd.

• 西 孝夫

  Tokushima Research Institute, Otsuka Pharmaceutical Co., Ltd.

• 田中 達義

  Tokushima Research Institute, Otsuka Pharmaceutical Co., Ltd.

• 田中 達義

  Tokushima Research Institute Otsuka Pharmaceutical Co. Ltd.

• 清水 剛文

  Tokushima Research Institute, Otsuka Pharmaceutical Co., Ltd.,

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