Studies on 2(1H)-Quinolinone Derivatives as Gastric Antiulcer Active Agents. Synthesis and Antiulcer Activities of Optically Active α-Amino Acid Derivatives of 2(1H)-Quinolinone and Oxindole(Medicinal Chemistry,Chemical)

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概要

• 論文の詳細を見る

• In order to study the relationship of structure to antiulcer activity, optical active a-amino acid derivatives of 2(1H)-quinolinone and oxindole were synthesized and tested for antiulcer activity against acetic acid-induced gastric ulcer in rats. The enantiomers of 2(1H)-quinolinone derivatives were obtained by optical resolution with (-)-brucine. The oxindole derivatives having different absolute configurations at the a-amino acid moiety were synthesized by oxidation of N-(4-chlorobenzoyl)-L-or -D-tryptophan. The antiulcer activity did not seem to be influenced by the α-amino acid chirality.

• 社団法人日本薬学会の論文
• 1987-02-25

著者

• 田房 不二男

  2nd Tokushima Institute Of New Drugs Research Otsuka Pharmaceutical Co. Ltd.

• 中川 量之

  2nd Tokushima Institute Of New Drugs Research Otsuka Pharmaceutical Co. Ltd.

• 中川 量之

  大塚製薬株式会社有機化学研究所

• 中川 量之

  Tokushima Research Institute Otsuka Pharmaceutical Co. Ltd.

• 中川 量之

  大塚製薬株式会社徳島研究所

• 小松 真

  大塚製薬(株)新薬第三研究所

• 内多 稔

  Tokushima Research Institute, Otsuka Pharmaceutical Co., Ltd.,

• 小松 真

  Tokushima Research Institute, Otsuka Pharmaceutical Co., Ltd.,

• 神辺 敏実

  Tokushima Research Institute, Otsuka Pharmaceutical Co., Ltd.,

• 田房 不二男

  Tokushima Research Institute, Otsuka Pharmaceutical Co., Ltd.

• 森田 誠治

  Tokushima Research Institute, Otsuka Pharmaceutical Co., Ltd.

• 森田 誠治

  Tokushima Research Institute Otsuka Pharmaceutical Co. Ltd.

• Uchida Masaki

  Faculty Of Pharmaceutical Sciences Josai University

• Uchida Masaatsu

  Departments Of Pharmacology Meiji Pharmaceutical University

• 神辺 敏実

  Tokushima Research Institute Otsuka Pharmaceutical Co. Ltd.

• Uchida Mihoko

  Department Of Biochemistry Faculty Of Pharmaceutical Sciences Hoshi University

• Uchida M

  Otsuka Pharmaceutical Co. Ltd. Tokushima Jpn

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