Effects of Particle Size, Helium Gas Pressure and Microparticle Dose on the Plasma Concentration of Indomethacin after Bombardment of Indomethacin-Loaded Poly-L-Lactic Acid Microspheres Using a Helios^<TM> Gun System
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概要
- 論文の詳細を見る
We investigated the effects of the particle size of indomethacin-loaded poly-L-lactic acid microspheres (IDM-loaded PLA MS), the helium pressure used to accelerate the particles, and the bombardment dose of PLA MS on the plasma concentration of IDM after bombarding with IDM-loaded PLA MS of different particle size ranges, 20-38, 44-53 and 75-100 μm, the abdomen of hairless rats using the Helios^<TM> gene gun system (HeIios^<TM> gun system). Using larger particles and a higher helium pressure, produced an increase in the plasma IDM concentration and the area under the plasma concentration-time curve (AUC) and resultant F (relative bioavailability with respect to intracutaneous injection) of IDM increased by an amount depending on the particle size and helium pressure. Although a reduction in the bombardment dose led to a decrease in C_<max> and AUC, F increased on decreasing the bombardment dose. In addition, a more efficient F was obtained after bombarding with IDM-loaded PLA MS of 75-100 μm in diameter at each low dose in different sites of the abdomen compared with that after bolus bombardment with a high dose (dose equivalent). These results suggest that the bombardment injection of drug-loaded microspheres by the Helios^<TM> gun system is a very useful tool for delivering a variety of drugs in powder form into the skin and systemic circulation.
- 公益社団法人日本薬学会の論文
- 2002-05-01
著者
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Sugibayashi Kenji
Faculty of Pharmaceutical Sciences, Josai University
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Morimoto Yasunori
Faculty of Pharmaceutical Sciences, Josai University
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Uchida Masaki
Faculty Of Pharmaceutical Sciences Josai University
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Kobayashi D
Fac. Of Pharmaceutical Sciences Josai Univ.
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森本 泰子
Department Of Pharmaceutics Faculty Of Pharmaceutical Sciences Kobe Gakuin University
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Morimoto Y
Josai Univ. Saitama Jpn
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Morimoto Y
Faculty Of Pharmaceutical Sciences Josai University:research Institute Of Tts Technology
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Morimoto Yasunori
Fac. Of Pharmaceutical Sciences Josai Univ.
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Morimoto Yasunori
Department Of Hospital Pharmacy Faculty Of Pharmaceutical Sciences Josai University
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Morimoto Yasunori
Faculty Of Pharmaceutical Sciences Josai University
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NATSUME Hideshi
Faculty of Pharmaceutical Sciences, Josai University
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KOBAYASHI Daisuke
Faculty of Pharmaceutical Sciences, Josai University
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Uchida Masaatsu
Departments Of Pharmacology Meiji Pharmaceutical University
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Morimoto Yasunori
Faculty Of Pharmaceutical Sciences Josai University:research Institute Of Tts Technology
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Sugibayashi Kenji
Faculty Of Pharmaceutial Sciences Josai University
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Sugibayashi Kenji
Faculty Of Pharmaceutical Sciences Josai University:research Institute Of Tts Technology
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Sugibayashi Kenji
Fac. Of Pharmaceutical Sciences Josai Univ.
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Sugibayashi Kenji
Josai-university Faculty Of Pharmaceutical Sciences
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Sugibayashi Kenji
Department Of Neuropathology Tokyo Metropolitan Institute For Neurosciences
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Uchida Mihoko
Department Of Biochemistry Faculty Of Pharmaceutical Sciences Hoshi University
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Sugibayashi K
Faculty Of Pharmaceutical Sciences Josai University:life Science Research Center Josai University
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Uchida M
Otsuka Pharmaceutical Co. Ltd. Tokushima Jpn
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Natsume Hideshi
Faculty Of Pharmaceutical Sciences Josai University:research Institute Of Tts Technology
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SUGIE Kenichi
Josai-University faculty of pharmaceutical sciences
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Kobayashi Daisuke
Fac. Of Pharmaceutical Sciences Josai Univ.
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