Chitosan Gel for Transdermal Delivery of Morphine Hydrochloride
スポンサーリンク
概要
- 論文の詳細を見る
We developed a chitosan (CHI) gel containing alcohols and l-menthol (MEN) as skin permeation enhancers, and succinic acid (SUC) as a cross-linking agent and examined the permeation of morphine hydrochloride (MPH) from the CHI gel into human skin. The solubility of CHI and MEN was measured beforehand in order to create a system saturated with these 2 substances. Solubility varied with the content of ethanol and 1,3-butylene glycol. The saturated CHI gel displayed sufficient elasticity to be applied to a fixed area of skin. The permeation of MPH into the skin from the CHI gel was compared with its permeation into the skin for a polyvinyl alcohol (PVA) gel having a similar composition. Permeation was greater for the CHI gel in the later stages of the experiment. Our CHI gel should thus be useful for the transdermal delivery of MPH.
- 2007-06-10
著者
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KIMURA Masayuki
Department of Pharmacy Services, Saitama Medical Center
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Sano Motohiko
Department Of Pharmacy Services Saitama Medical Center Saitama Medical University:faculty Of Pharmac
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Hosoya Osamu
Research Institute of TTS Technology
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Seki Toshinobu
Research Institute of TTS Technology
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Morimoto Kazuhiro
Hokkaido Pharmaceutical University School of Pharmacy
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Morimoto Yasunori
Faculty of Pharmaceutical Sciences, Josai University
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Juni Kazuhiko
Faculty of Pharmaceutical Sciences, Josai University
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Hosoya O
Department Of Pharmacy Japanese Red Cross Hospital Omori
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Hosoya O
Niigata Univ. Niigata Jpn
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Hosoya Osamu
Research Institute Of Tts Technology Josai University
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Sano Motohiko
Department Of Parasitology Hamamatsu University School Of Medicine
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Juni K
Faculty Of Pharmaceutical Sciences Josai University
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Juni Kazuhiko
北海道薬科大学
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Juni Kazuhiko
Faculty Of Pharmaceutical Sciences Hokkaido University
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Seki T
Department Of Pharmaceutics Graduate School Of Pharmaceutical Sciences Hokkaido Pharmaceutical Unive
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Seki Toshinobu
Hokkaido Pharmaceutical University School Of Pharmacy
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森本 泰子
Department Of Pharmaceutics Faculty Of Pharmaceutical Sciences Kobe Gakuin University
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Morimoto Y
Josai Univ. Saitama Jpn
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Morimoto Y
Faculty Of Pharmaceutical Sciences Josai University:research Institute Of Tts Technology
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Morimoto Yasunori
Fac. Of Pharmaceutical Sciences Josai Univ.
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Morimoto Yasunori
Department Of Hospital Pharmacy Faculty Of Pharmaceutical Sciences Josai University
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Morimoto Yasunori
Faculty Of Pharmaceutical Sciences Josai University
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Seki T
Department Of Nutrition And Physiology Nihon University College Of Bioresource Sciences
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Seki T
Hokkaido Pharmaceutical University School Of Pharmacy
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Morimoto Yasunori
Faculty Of Pharmaceutical Sciences Josai University:research Institute Of Tts Technology
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Morimoto Kazuhiro
Department Of Pharmaceutics Graduate School Of Pharmaceutical Sciences Hokkaido Pharmaceutical Unive
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Sano M
Department Of Pharmacy Services Saitama Medical Center Saitama Medical University:faculty Of Pharmac
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Morimoto K
Hokkaido Pharmaceutical University School Of Pharmacy
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Kimura Masayuki
Department Of Electrical Engineering Kyoto University
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Kimura Masayuki
Department Of Pharmacy Services Saitama Medical Center Saitama Medical University
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