Studies on Agents with Vasodilator and β-Blocking Activities. I
スポンサーリンク
概要
- 論文の詳細を見る
A series of hydrazinopyridazine derivatives combined with a β-blocking side chain were synthesized. When they were given intravenously to anesthetized rats, some of them exhibited both hypotensive and β-blocking activities. Their structure-activity relationships for hypotensive and β-blocking activities are discussed. Compound 11c had the best profile and was selected for further study.
- 社団法人日本薬学会の論文
- 1994-08-15
著者
-
石森 勉
Research Division Teikoku Hormone Manufacturing Co. Ltd.
-
安田 喜久男
Research Laboratory, Teikoku Hormone Mfg. Co., Ltd.
-
安田 喜久男
Research Division Teikoku Hormone Manufacturing Co. Ltd.
-
関 敏美
Research Division, Teikoku Hormone Manufacturing Co., Ltd.,
-
竹崎 孝行
Research Division, Teikoku Hormone Manufacturing Co., Ltd.,
-
大内 力男
Research Division, Teikoku Hormone Manufacturing Co., Ltd.,
-
大藪 宏
Research Division, Teikoku Hormone Manufacturing Co., Ltd.,
-
Seki Taiichiro
Lab. Of Nutrition And Physiology Dep. Of Chemistry And Life Sci. Nihon Univ. Coll. Of Bioresource Sc
-
Seki T
Department Of Nutrition And Physiology Nihon University College Of Bioresource Sciences
-
関 敏美
Research Division Teikoku Hormone Manufacturing Co. Ltd.
-
大内 力男
Research Division Teikoku Hormone Manufacturing Co. Ltd.
-
大藪 宏
Research Division Teikoku Hormone Manufacturing Co. Ltd.
-
竹崎 孝行
Research Division Teikoku Hormone Manufacturing Co. Ltd.
-
Yamashita K
Faculty Of Pharmaceutical Sciences Okayama University
関連論文
- Further Preparation of Steroidal Diosphenols. I. Synthesis of Some 4,4-Dimethyl-2-hydroxy-3-oxo-1-ene Steroids in Androstane and Pregnane Series
- Synthesis of Some 3,5-Diene-2,7-dioxosteroids
- Chitosan Gel for Transdermal Delivery of Morphine Hydrochloride
- In Vitro Skin Permeation of Morphine Hydrochloride during the Finite Application of Penetration-Enhancing System Containing Water, Ethanol and l-Menthol
- Studies on Agents with Vasodilator and β-Blocking Activities. III. Synthesis and Activity of Optical Isomers of TZC-1370
- Studies on Agents with Vasodilator and β-Blocking Activities. II
- Studies on Agents with Vasodilator and β-Blocking Activities. I
- Synthesis of 2α-Halo-4-en-3-oxo-steroids
- Long-range Effect of Halogen in the Nuclear Magnetic Resonance Spectra of Halosteroids
- Oxidation of 3-Enol Derivatives of 4-En-3-oxo-steroids by tert-Butyl Chromate.
- Preparation of Some Estriol Esters.
- Effect of l-Menthol-Ethanol-Water System on the Systemic Absorption of Flurbiprofen after Repeated Topical Applications in Rabbits
- Insoluble Fiber Is a Major Constituent Responsible for Lowering the Post-Prandial Blood Glucose Concentration in the Pre-Germinated Brown Rice(Biopharmacy)
- Annexin A3 Expression Increases in Hepatocytes and is Regulated by Hepatocyte Growth Factor in Rat Liver Regeneration
- Bromocriptine Reverses P-Glycoprotein-mediated Multidrug Resistance in Tumor Cells
- Bromocriptine Reverses P-Glycoprotein-mediated Multidrug Resistance in Tumor Cells
- Inhibitory Effect of Human Immunodeficiency Virus Protease Inhibtors on Multidrug Resistance Transporter P-Glycoproteins
- Cloning and Expression in Escherichia coli of 2-Hydroxypropylphosphonic Acid Epoxidase from the Fosfomycin-producing Organism, Pseudomonas syringae PB-5123
- Nucleotide Sequence of Fortimicin KL1 Methyltransferase Gene Isolated from Micromonospora olivasterospora, and Comparison of Its Deduced Amino Acid Sequence with Those of Methyltransferases Involved in the Biosynthesis of Bialaphos and Fosfomycin
- Evaluation of the Establishment of a Tight Junction in Caco-2 Cell Monolayers Using a Pore Permeation Model Involving Two Different Sizes(Biopharmacy)
- A Novel Preparation Method for Microspheres of Water Soluble Polymers Using Polypropyleneglycol as the Dispersion Medium
- Measurement of diffusion coefficients of parabens and steroids in water and 1-octanol
- Measurement of Diffusion Coefficients of Parabens and Steroids in Water and 1-Octanol
- Effect of Temperature on Drug Release from Copoly (L-Lactic Acid/δ-Valerolactone) Microspheres
- Relationship between Solubility of Chitosan in Alcoholic Solution and Its Gelation
- Effect of Several Hydrophilic Polymers on the Permeation of Morphine and Salicylic Acid through Excised Hairless Rat Skin
- Analysis of Skin Disposition of Flurbiprofen after Topical Application Using Dual Agar Gel Discs-Inserted Rats(Biopharmacy)
- Skin Disposition of Drugs after Topical Application in Hairless Rats
- Studies on Agents with Vasodilator and β-Blocking Activities. IV
- Replacing White Rice with Pre-Germinated Brown Rice Mildly Ameliorates Hyperglycemia and Imbalance of Adipocytokine Levels in Type 2 Diabetes Model Rats
- Novel Experimental System as an Alternative to Animal Experiments to Study the Skin Permeation of Drugs
- Thrombomodulin Enhances the Invasive Activity of Mouse Mammary Tumor Cells
- Measurement of Diffusion Coefficients of Parabens by the Chromatographic Broadening Method
- Studies on Agents with Vasodilator and β-Blocking Activities. V. Synthesis and Pharmacological Activity of the Optical Isomers of TZC-5665
- Syntheses of Azabenzobicycloalkanes
- Change in Annexin A3 Expression by Regulatory Factors of Hepatocyte Growth in Primary Cultured Rat Hepatocytes(Molecular and Cell Biology)
- Expression of Annexin A3 in Primary Cultured Parenchymal Rat Hepatocytes and Inhibition of DNA Synthesis by Suppression of Annexin A3 Expression Using RNA Interference(Biochemistry/Molecular Biology)
- Isolated Small Rat Hepatocytes Express both Annexin III and Terminal Differentiated Hepatocyte Markers, Tyrosine Aminotransferase and Tryptophan Oxygenase, at the mRNA Level(Biochemistry/Molecular Biology)
- Activins A, AB, and B Inhibit Hepatocyte Growth Factor Synthesis by MRC-5 Human Lung Fibroblasts
- Effect of Activins AB and B on DNA Synthesis Stimulated by Epidermal Growth Factor in Primary Cultured Rat Hepatocytes
- Purification and Characterization of Hepatic Plasminogen Activator (h-PA) in the Conditioned Medium of Rat Hepatocytes in Primary Culture
- Rare Earth Metal Trifluoromethanesulfonates Catalyzed Benzyl-Etherification
- Antibacterial Potential of Garlic-Derived Allicin and Its Cancellation by Sulfhydryl Compounds
- Verification of the Antidiabetic Effects of Cinnamon (Cinnamomum zeylanicum) Using Insulin-Uncontrolled Type 1 Diabetic Rats and Cultured Adipocytes
- Thermostability of Allicin Determined by Chemical and Biological Assays
- Annexin A3-Expressing Cellular Phenotypes Emerge from Necrotic Lesion in the Pericentral Area in 2-Acetylaminofluoren/Carbon Tetrachloride-Treated Rat Livers