In Vitro Skin Permeation of Morphine Hydrochloride during the Finite Application of Penetration-Enhancing System Containing Water, Ethanol and l-Menthol
スポンサーリンク
概要
- 論文の詳細を見る
The effects of composition of applied solutions, containing water, ethanol(EtOH)and l-menthol(LM)as penetration enhancers, on the in vitro permeation of morphine hydrochloride(MPH)through excised hairless rat skin were examined in finite application experiments. Three of the five different applied solutions contained almost saturated LM and two contained levels of LM below the limit of solubility. Depite similar pseudo steadystate fluxes(maximum fluxes observed)of MPH from the solutions, lag time for the permeation of MPH from the saturated systems was shorter than that from the unsaturated systems. Lag times for the permeation of EtOH and LM from the saturated systems were also shorter than those from the unsaturated systems. Thermodynamic activity of LM is important for the enhancing effect against MPH permeation. At the beginning for the permeation experiment, the activity of LM in the unsaturated systems was lower than that in the saturated solutions. As the skin permeability of EtOH was higher than that of other components, the content of EtOH in the applied solution gradually dereased with time, while the activity of LM increased eventually showing a sufficient enhancing effect. Solvent drag effect was not important for the permeation of MPH, since penetration rate of MPH was independent of the time course of that of EtOH. The amount of LM migrating into skin appeared to be the most important parameter for the penetration-enhancing effect of the mixed system in the in vitro permeation of MPH through excised hairless rat skin.
- 2002-01-01
著者
-
Sugibayashi Kenji
Faculty of Pharmaceutical Sciences, Josai University
-
Morimoto Yasunori
Faculty of Pharmaceutical Sciences, Josai University
-
Wada Y
Faculty Of Pharmaceutical Sciences Research Institute Of Tts Technology
-
Seki T
Department Of Pharmaceutics Graduate School Of Pharmaceutical Sciences Hokkaido Pharmaceutical Unive
-
Seki Toshinobu
Hokkaido Pharmaceutical University School Of Pharmacy
-
Seki Toshinobu
Faculty Of Pharmaceutical Sciences Josai University
-
森本 泰子
Department Of Pharmaceutics Faculty Of Pharmaceutical Sciences Kobe Gakuin University
-
Morimoto Y
Josai Univ. Saitama Jpn
-
Morimoto Y
Faculty Of Pharmaceutical Sciences Josai University:research Institute Of Tts Technology
-
Morimoto Yasunori
Fac. Of Pharmaceutical Sciences Josai Univ.
-
Morimoto Yasunori
Department Of Hospital Pharmacy Faculty Of Pharmaceutical Sciences Josai University
-
Morimoto Yasunori
Faculty Of Pharmaceutical Sciences Josai University
-
Seki T
Department Of Nutrition And Physiology Nihon University College Of Bioresource Sciences
-
Seki T
Hokkaido Pharmaceutical University School Of Pharmacy
-
WADA Yoshio
Faculty of Pharmaceutical Sciences, Research Institute of TTS Technology
-
Morimoto Yasunori
Faculty Of Pharmaceutical Sciences Josai University:research Institute Of Tts Technology
-
Sugibayashi Kenji
Faculty Of Pharmaceutial Sciences Josai University
-
Sugibayashi Kenji
Faculty Of Pharmaceutical Sciences Josai University:research Institute Of Tts Technology
-
Sugibayashi Kenji
Fac. Of Pharmaceutical Sciences Josai Univ.
-
Sugibayashi Kenji
Josai-university Faculty Of Pharmaceutical Sciences
-
Sugibayashi Kenji
Department Of Neuropathology Tokyo Metropolitan Institute For Neurosciences
-
Wada Yoshio
Faculty Of Pharmaceutical Sciences Research Institute Of Tts Technology
-
Sugibayashi K
Faculty Of Pharmaceutical Sciences Josai University:life Science Research Center Josai University
-
Wada Y
Yakult Central Institute For Microbiological Research
-
SUGIE Kenichi
Josai-University faculty of pharmaceutical sciences
関連論文
- Effect of Thermodynamic Activity on Skin Permeation and Skin Concentration of Triamcinolone Acetonide
- Permeation Pathway of Macromolecules and Nanospheres through Skin
- Effects of Fatty Acids, Fatty Amines and Propylene Glycol on Rat Stratum Corneum Lipids and Proteins in Vitro Measured by Fourier Transform Infrared/Attenuated Total Reflection (FT-IR/ATR) Spectroscopy
- Destabilization of Whole Skin Lipid Bio-liposomes Induced by Skin Penetration Enhancers and FT-IR/ATR (Fourier Transform Infrared/Attenuated Total Reflection) Analysis of Stratum Corneum Lipids
- Behavior of Propylene Glycol (PG) in Dermis after Treatment of Rat Intact Skin Surface with Fatty Acids, Fatty Amines or Azone Dissolved in PG
- Effects of Oleic Acid/Propylene Glycol on Rat Abdominal Stratum Corneum : Lipid Extraction and Appearance of Propylene Glycol in the Dermis Measured by Fourier Transform Infrared/Attenuated Total Reflectance (FT-IR/ATR) Spectroscopy
- 呼吸器感染症治療の最適化を目的としたテリスロマイシンの肺組織移行特性の評価
- Chitosan Gel for Transdermal Delivery of Morphine Hydrochloride
- In Vitro Skin Permeation of Morphine Hydrochloride during the Finite Application of Penetration-Enhancing System Containing Water, Ethanol and l-Menthol
- Preparation and Evaluation of Liquid-Crystal Formulations with Skin-permeation-enhancing Abilities for Entrapped Drugs
- Analysis of the Rat Skin Permeation of Hydrophilic Compounds Using the Renkin Function
- リポソーム中の脂質の過酸化に対するタウリンの抑制作用
- Protective Effects of Some Neutral Amino Acids against Hypotonic Hemolysis
- Studies on Agents with Vasodilator and β-Blocking Activities. III. Synthesis and Activity of Optical Isomers of TZC-1370
- Studies on Agents with Vasodilator and β-Blocking Activities. II
- Studies on Agents with Vasodilator and β-Blocking Activities. I
- Effect of l-Menthol-Ethanol-Water System on the Systemic Absorption of Flurbiprofen after Repeated Topical Applications in Rabbits
- Effect of Aminated Gelatin on the Nasal Absorption of Insulin in Rats(Biopharmacy)
- Design and Feasibility Assessment of Topically Applied Drug Formulations for Electroporation
- Protective Effects of Neutral Amino Acids against Amphipathic Drug-Induced Hemolysis
- Protective Effect of Glycine against Liposome Membrane-Perturbation and Lysis Induced by Chlorpromazine
- ESR Study of Membrane Perturbation and the Lysis of Liposomes Induced by Chlorpromazine
- Insoluble Fiber Is a Major Constituent Responsible for Lowering the Post-Prandial Blood Glucose Concentration in the Pre-Germinated Brown Rice(Biopharmacy)
- Annexin A3 Expression Increases in Hepatocytes and is Regulated by Hepatocyte Growth Factor in Rat Liver Regeneration
- Effect of Camellia Oil on the Permeation of Flurbiprofen and Diclofenac Sodium through Rat and Pig Skin(Biopharmacy)
- Effect of Penetration Enhancers on the Permeation of Drugs across a Three-Dimensional Cultured Human Skin Model : Comparison with the Effects Using Excised Hairless Rat Skin
- Utility of the Three-Dimensional Cultured Human Skin Model as a Tool to Evaluate Skin Permeation of Drugs
- Evaluation of the Establishment of a Tight Junction in Caco-2 Cell Monolayers Using a Pore Permeation Model Involving Two Different Sizes(Biopharmacy)
- A Novel Preparation Method for Microspheres of Water Soluble Polymers Using Polypropyleneglycol as the Dispersion Medium
- Measurement of diffusion coefficients of parabens and steroids in water and 1-octanol
- Measurement of Diffusion Coefficients of Parabens and Steroids in Water and 1-Octanol
- Effect of Temperature on Drug Release from Copoly (L-Lactic Acid/δ-Valerolactone) Microspheres
- Relationship between Solubility of Chitosan in Alcoholic Solution and Its Gelation
- Effect of Several Hydrophilic Polymers on the Permeation of Morphine and Salicylic Acid through Excised Hairless Rat Skin
- Effects of Application Voltage and Cathode and Anode Positions at Electroporation on the in Vitro Permeation of Benzoic Acid through Hairless Rat Skin
- Decrease in Skin Permeation and Antibacterial Effect of Parabens by a Polymeric Additive, Poly(2-methacryloyloxyethyl phosphorylcholine-co-butylmetacrylate)
- Analysis of Skin Disposition and Metabolism of Ethyl Nicotinate after Topical Application Using Dual Agar Gel Disc-Inserted Rats(Biopharmacy)
- Analysis of Skin Disposition of Flurbiprofen after Topical Application Using Dual Agar Gel Discs-Inserted Rats(Biopharmacy)
- Pharmacokinetic Profile of Flavin Adenine Dinucleotide, Flavin Mononucleotide and Riboflavin Following Intravenous Administration of Riboflavin or Its Coenzymes in Rats
- Utility of a Three-Dimensional Cultured Human Skin Model as a Tool to Evaluate the Simultaneous Diffusion and Metabolism of Ethyl Nicotinate in Skin
- Skin Disposition of Drugs after Topical Application in Hairless Rats
- Ability of Poly-L-arginine to Enhance Drug Absorption into Aqueous Humor and Vitreous Body after Instillation in Rabbits(Biopharmacy)
- A Protective Effect against Undesirable Increase of Dihydroetorphine Permeation through Damaged Skin by Using Pressure-Sensitive Adhesive Tape with an Ethylene-Vinyl Acetate Co-Polymer Membrane
- BIOMEDICAL APPLICATIONS OF MAGNETIC FLUIDS. II. PREPARATION AND MAGNETIC GUIDANCE OF MAGNETIC ALBUMIN MICROSPHERE FOR SITE SPECIFIC DRUG DELIVERY IN VIVO
- BIOMEDICAL APPLICATIONS OF MAGNETIC FLUIDS. I. MAGNETIC GUIDANCE OF FERRO-COLLOID-ENTRAPPED ALBUMIN MICROSPHERE FOR SITE SPECIFIC DRUG DELIVERY IN VIVO
- DRUG-CARRIER PROPERTY OF ALBUMIN MICROSPHERES IN CHEMOTHERAPY. III. EFFECT OF MICROSPHERE-ENTRAPPED 5-FLUOROURACIL ON EHRLICH ASCITES CARCINOMA IN MICE
- INFLUENCE OF ETHANOL AND POLYETHYLENE GLYCOL UPON THE SKIN PERMEATION OF DRUGS
- THE DEVELOPMENT OF A MAGNETIC EMULSION AS DRUG CARRIER
- Liquid Chromatographic Determination of Plasma Ropivacaine for Assessing Pharmacokinetics of the Viscous Preparation(Biopharmacy)
- Difference in the Enhancing Effects of Ultrasound on the Skin Permeation of Polar and Non-polar Drugs
- Enhancing Effect of N-Acetyl-L-cysteine or 2-Mercaptoethanol on the in Vitro Permeation of 5-Fluorouracil or Tolnaftate through the Human Nail Plate
- Effects of Particle Size, Helium Gas Pressure and Microparticle Dose on the Plasma Concentration of Indomethacin after Bombardment of Indomethacin-Loaded Poly-L-Lactic Acid Microspheres Using a Helios^ Gun System
- Evaluation of Bile Acids and Fusidate Derivative as Nasal Absorption Enhancers Using an Electrophysiological Technique
- Iontophoretic Transport of Morphine across Hairless Rat Skin : Is a Further Increase Obtained with Chemical Enhancer?
- Evaluation of Skin Permeability of Drugs by Newly Prepared Polymer Membranes
- Analysis of in Vitro Iontophoretic Skin Permeation of Sodium Benzoate by Transport Numbers of Drug and Additives
- PREPARATION AND APPLICATION OF ALBUMIN MICROSPHERES CONTAINING ANTITUMOR AGENTS AS A DRUG CARRIER FOR CHEMOEMBOLIZATION
- Influence of Skin Hydration on Anesthetic Effect of Lidocaine Tape in Hemodialysis Patients
- Effects of Poly-L-arginine on the Permeation of Hydrophilic Compounds through Surface Ocular Tissues(Biopharmacy)
- Investigation of the Release Test Method for the Topical Application of Pharmaceutical Preparations : Release Test of Cataplasm Including Nonsteroidal Anti-inflammatory Drugs Using Artificial Sweat
- The Enhancing Effect of a Triethanolamine-Ethanol-Isopropyl Myristate Mixed System on the Skin Permeation of Acidic Drugs(Biopharmacy)
- ANTITUMOR AGENT POLY (AMINO ACID) CONJUGATES AS A DRUG CARRIER IN CANCER CHEMOTHERAPY
- Studies on Agents with Vasodilator and β-Blocking Activities. IV
- Replacing White Rice with Pre-Germinated Brown Rice Mildly Ameliorates Hyperglycemia and Imbalance of Adipocytokine Levels in Type 2 Diabetes Model Rats
- Conversion of FAD to FMN and Riboflavin in Plasma : Effects of Measuring Method(Biopharmacy)
- Novel Experimental System as an Alternative to Animal Experiments to Study the Skin Permeation of Drugs
- Thrombomodulin Enhances the Invasive Activity of Mouse Mammary Tumor Cells
- Measurement of Diffusion Coefficients of Parabens by the Chromatographic Broadening Method
- Studies on Agents with Vasodilator and β-Blocking Activities. V. Synthesis and Pharmacological Activity of the Optical Isomers of TZC-5665
- The Effects of Calcium Chloride and Sodium Chloride on the Electroporation-Mediated Skin Permeation of Fluorescein Isothiocyanate (FITC)-Dextrans in Vitro(Biopharmacy)
- Effect of Sebum and Ointment Rubbing on the Skin Permeation of Triamcinolone Acetonide from White Petrolatum Ointment
- Safety evaluation of titanium dioxide nanoparticles by their absorption and elimination profiles
- Acoustic Cavitation as an Enhancing Mechanism of Low-Frequency Sonophoresis for Transdermal Drug Delivery
- Change in Annexin A3 Expression by Regulatory Factors of Hepatocyte Growth in Primary Cultured Rat Hepatocytes(Molecular and Cell Biology)
- Expression of Annexin A3 in Primary Cultured Parenchymal Rat Hepatocytes and Inhibition of DNA Synthesis by Suppression of Annexin A3 Expression Using RNA Interference(Biochemistry/Molecular Biology)
- Isolated Small Rat Hepatocytes Express both Annexin III and Terminal Differentiated Hepatocyte Markers, Tyrosine Aminotransferase and Tryptophan Oxygenase, at the mRNA Level(Biochemistry/Molecular Biology)
- Activins A, AB, and B Inhibit Hepatocyte Growth Factor Synthesis by MRC-5 Human Lung Fibroblasts
- Variation Assessment for in Vitro Permeabilities through Yucatan Micropig Skin
- Relationships between the Particle Velocity and Introduction of Drug-Loaded Microparticles into the Skin in a Microparticulate Bombardment System
- Nitrogen-15 NMR Spectroscopy of Sugar Sensor with B-N Interaction as a Key Regulator of Colorimetric Signals
- 抗菌薬の肺投与は経口投与に比べて呼吸器感染症の治療においてメリットがあるか
- Effect of Lecithin Coating on the Pulmonary Absorption of Furosemide in Rats(Biopharmacy)
- Intranasal Administration of Milnacipran in Rats: Evaluation of the Transport of Drugs to the Systemic Circulation and Central Nervous System and the Pharmacological Effect
- Evaluation of three dimensional cultured skin models using membrane permeation test
- Permeation of several compounds through different three-dimensional cultured human skin models
- Potent Hypocholesterolemic Activity of the Yeast Kluyveromyces marxianus YIT 8292 in Rats Fed a High Cholesterol Diet
- Structure-Activity Relationships of N-(3, 5-Dimethoxy-4-n-octyloxycinnamoyl)-N'-(3, 4-dimethylphenyl)piperazine and Analogues as Inhibitors of Acyl-CoA : Cholesterol O-Acyltransferase
- A new evaluation system for in vitro skin permeation to screen skin penetration enhancers
- Macromolecular Delivery into Skin Using a Hollow Microneedle
- In Vitro Characterization of the Cytochrome P450 Isoforms Involved in the Metabolism of 6-Methoxy-2-napthylacetic Acid, an Active Metabolite of the Prodrug Nabumetone
- Suitability of Synthetic Copolymer Membranes as a Human Skin Alternative for In Vitro Skin Permeation Testing
- Study of a Drug Interaction Involving the Permeation Process Using an Artificial Skin Model as an Alternative to Animal Skin
- Mathematical Analysis on The Release of Ketotifen from Silicone Pressure Sensitive Adhesive Matrices Containing Its Crystalline or Amorphous Form
- The Use of an Artificial Skin Model to Study Transdermal Absorption of Drugs in Inflamed Skin
- Effect of poly-L-arginine on intestinal absorption of hydrophilic macromolecules in rats
- Poly-L-arginine-induced internalization of tight junction proteins increases the paracellular permeability of the Caco-2 cell monolayer to hydrophilic macromolecules
- Sugar-sensitive supramolecular structures based on phenylboronic acid-modified cyclodextrins
- Evaluation of the Effects of Absorption Enhancers on Caco-2 Cell Monolayers by Using a Pore Permeation Model Involving Two Different Sizes
- Poly-L-arginine-Induced Internalization of Tight Junction Proteins Increases the Paracellular Permeability of the Caco-2 Cell Monolayer to Hydrophilic Macromolecules
- Serotonin Suppresses β-Casein Expression via Inhibition of the Signal Transducer and Activator of Transcription 5 (STAT5) Protein Phosphorylation in Human Mammary Epithelial Cells MCF-12A