Studies on Agents with Vasodilator and β-Blocking Activities. V. Synthesis and Pharmacological Activity of the Optical Isomers of TZC-5665
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概要
- 論文の詳細を見る
Synthesis of the four optical isomers of TZC-5665 (1), a candidate for the treatment of congestive heart failure, was achieved by the reaction of chiral diaminopyridazinone (2) with chiral glycidyl ether (3). The hypotensive and β-blocking activities of 1 and its optical isomers were examined when given intravenously into anesthetized rats. Furthermore these compounds were evaluated for inhibitory activity on cAMP phosphodiesterase III. Among the four optical isomers. R_A, S_B-one (1c) possessed the essential activities of TZC-5665 (1).
- 公益社団法人日本薬学会の論文
- 1998-01-15
著者
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Asano Hajime
Research Division Teikoku Hormone Manufacturing Co. Ltd.
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Seki Taiichiro
Lab. Of Nutrition And Physiology Dep. Of Chemistry And Life Sci. Nihon Univ. Coll. Of Bioresource Sc
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Seki T
Department Of Nutrition And Physiology Nihon University College Of Bioresource Sciences
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SHIBATA KENYU
Research and Development Division, Teikoku Hormone Mfg. Co., Ltd.
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SEKI Toshimi
Research Division, Teikoku Hormone Manufacturing Co., Ltd.
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NAKAO Tomio
Research Division, Teikoku Hormone Manufacturing Co., Ltd.
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ISHIMORI Tsutomu
Research Division, Teikoku Hormone Manufacturing Co., Ltd.
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MINAMI Nobuyoshi
Research Division, Teikoku Hormone Manufacturing Co., Ltd.
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YASUDA Kikuo
Research Division, Teikoku Hormone Manufacturing Co., Ltd.
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KANADA Arihiro
Research Division, Teikoku Hormone Manufacturing Co., Ltd.,
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SHIRAIWA Masahumi
Research Division, Teikoku Hormone Manufacturing Co., Ltd.,
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MIYAZAWA Katsuhiko
Research Division, Teikoku Hormone Manufacturing Co., Ltd.,
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Nakao T
Research Division Teikoku Hormone Manufacturing Co. Ltd.
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関 敏美
Research Division Teikoku Hormone Manufacturing Co. Ltd.
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Shibata Kenyu
Research Division Teikoku Hormone Manufacturing Co. Ltd.
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Kanada Arihiro
Research Division Teikoku Hormone Manufacturing Co. Ltd.
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Minami N
Research Division Teikoku Hormone Manufacturing Co. Ltd.
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Ishimori T
Research Division Teikoku Hormone Manufacturing Co. Ltd.
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Shiraiwa M
Research Division Teikoku Hormone Manufacturing Co. Ltd.
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Miyazawa Katsuhiko
Research Division Teikoku Hormone Manufacturing Co. Ltd.
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Yamashita K
Faculty Of Pharmaceutical Sciences Okayama University
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