Action of a novel nonsteroidal antiandrogen, AA560.
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概要
- 論文の詳細を見る
The antiandrogenic properties of a new nonsteroidal antiandrogens, AA560 (N-(2-chloromethyl-2-hydroxypropionyl)-3, 4, 5-trichloroaniline) were investigated. The ventral prostate, dorselateral prostate and coagulating gland weights in rats given AA560 at1-9mg/head were significantly less than those in the intact rats. The seminal vesicle weights in rats given3-9mg/head were significantly less than those of the intact group. In intact animals given daily3or9mg of AA560there were significantly increases of serum FSH, LH and testosterone concentrations.<BR>In the in vivo experiment, the pretreatment with AA560decreased the uptake of <SUP>3</SUP>H-androgens in the nuclear fraction of the ventral prostate. On the other hand, a significant increase in the uptake of<SUP>3</SUP>H-radioactivity in the cytosol fraction was observed.<BR>It was proved by the <I>in vitro</I> displacement study that AA560inhibited the binding of 5α-dihydrotestosterone with a receptor protein in the prostatic cytosol.
- 社団法人 日本内分泌学会の論文
著者
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SHIBATA KENYU
Research and Development Division, Teikoku Hormone Mfg. Co., Ltd.
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Yamanaka Hidetoshi
Department Of Materials Science Osaka Electro-communication University
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Koya Atsushi
Department Of Urology Gunma University School Of Medicine
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Wakabayashi Katsumi
Hormone Assay Center Institute Of Endocrinology Gumma Univ.
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SHIDA KEIZO
Department of Urology School of Medicine, Gunma University
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YAMANAKA HIDETOSHI
Department of Urology School of Medicine, Gunma University
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MORI HIROSHI
Research Division, Teikoku Hormone Mfg. Co.
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SHIMAZAWA EIICHIRO
Research Division, Teikoku Hormone Mfg. Co.
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SHIBATA KENYU
Research Division, Teikoku Hormone Mfg. Co.
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