Reduction of 5α-Position of Testosterone in the Rat Ventral Prostate
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概要
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The rate of 5α-reduction and 17β-dehydrogenation of testosterone added <I>in vitro</I>, the activity of Na<SUP>+</SUP>, K<SUP>+</SUP>-insensitive ATPase, and the content of citrate were determined in the ventral prostate of rats of various ages and of castrated animals with and without testosterone replacement therapy.<BR>The rate of 5α-reduction of testosterone changed significantly with aging of the gland, while no significant changes were observed in the rate of 17β-dehydrogenation of testosterone and ATPase activity in all animals used in this experiment. Although the rate of 5α-reduction in the old rat was very low, testosterone treatment increased the rate markedly. Castration caused a significant decrease in the rate of 5α-reduction, and the administration of testosterone restored the rate to the control level. This rate of 5α-reduction recovered to the control level on the 4th day after a testosterone treatment had been started prior to complete growth of the tissue in the castrated animals. These changes of the rate of 5α-reduction proceeded those of the citrate content of the gland.<BR>Physiological significance of 5α-reduction of testosterone in the rat ventral prostate was discussed.
- 社団法人 日本内分泌学会の論文
著者
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Yamanaka Hidetoshi
Department Of Materials Science Osaka Electro-communication University
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SHIDA KEIZO
Department of Urology, Gunma University School of Medicine
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FURUYA NOBUO
Department of Urology, Gunma University School of Medicine
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Shimazaki Jun
Department Of Ophthalmology School Of Medicine Keio University
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MATSUSHITA IWAO
Department of Urology, Gunma University School of Medicine
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SHIMAZAKI JUN
Department of Dermatology, School of Medicine, Chiba University
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SHIDA KEIZO
Department of Urology School of Medicine, Gunma University
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