Further Studies on Testosterone 5α-Reduction in Rat Ventral Prostate

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The increase in weight of the rat ventral prostate after testosterone administration to castrated rats was shown to be accompanied with concomitant elevations of both the rate of testosterone 5α-reduction and that of the incorporation of choline-3H into phospholipids in the glands. Time course study revealed that the increase in rate of 5α-reduction and of choline-3H incorporation became evident by 24 hrs after testosterone administration. The increase in rate of 5α-reduction and of choline-3H incorporation into phospholipids was observed in both microsomal and crude nuclear fractions from castrated rats 24 hrs after testosterone administration. The rate of 5α-reduction and DNA content exhibited the similar recovery after the purification of nuclei, however the radioactivity of choline-3H in the crude prostatic nuclei was lost during the procedure for purification of the nuclei. Therefore, it was concluded that the increase in rate of 5areduction and choline-3H incorporation into phospholipids took place simultaneously after the administration of testosterone, however sites of increased testosterone 5α-reductase did not seem to be located on the newly synthetized membranes. 5α-Androst-l-ene-17β-ol-3-one, known to be a potent androgen, evoked a similar increase in DNA content, the rate of 5α-reduction and DNA polymerase activity after testosterone administration to ventral prostate of castrated rats. This suggested that the increase in testosterone 5α-reduction observed did not seem to be a substrate-induced change.
社団法人日本内分泌学会の論文

Further Studies on Testosterone 5α-Reduction in Rat Ventral Prostate

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