Immunohistochemical study of metallothionein in human testicular tumors.
スポンサーリンク
概要
- 論文の詳細を見る
The localization of metallothionein (MT) in twenty-nine cases of testicular tumor was investigated using an immunoperoxidase method. Fifteen patients had typical seminoma in the primary tumor, two showed seminoma with embryonal carcinoma, one seminoma with choriocarcinoma, three embryonal carcinoma, two teratocarcinoma, three immature teratoma, one teratoma with yolk sac tumor, one teratoma with malignant transformation, one malignant lymphoma, and three metastatic retroperitoneal tumors. Positive immunoreactivity for MT was observed in embryonal carcinoma, well differentiated tissue (cartilaginous cells, gastrointestinal and respiratory mucosa, squamous epithelium), tumor cells differentiated into neural and muscular cells in teratocarcinoma, and differentiated embryonal carcinoma cells in immature teratoma. Tumor cells remaining after chemotherapy including cisplatin showed positive immunoreactivity for MT. However, seminoma cells showed almost no immunoreaction. The present study suggested that MT is detected in well differentiated cells of testicular tumors and may be useful marker for drug resistance.
- 北関東医学会の論文
著者
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Yamanaka Hidetoshi
Department Of Materials Science Osaka Electro-communication University
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Suzuki Takanori
Deparment Of Biological Science Graduate School Of Science Hiroshima University
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Ohma Chikako
Department Of Urology Gunma University School Of Medicine
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Suzuki Kazuhiro
Department Of Cardiovascular Surgery Yamaguchi Grand Medical Center
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Suzuki Keiji
Department Of Electrical Engineering Nagoya University
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Ohma Chikako
Department of Urology, and Department of Medical Technology, Gunma University School of Medicine, and Arima Clinic
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Jinbo Susumu
Department of Urology, and Department of Medical Technology, Gunma University School of Medicine, and Arima Clinic
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Yamanaka Hidetoshi
Department of Urology, and Department of Medical Technology, Gunma University School of Medicine, and Arima Clinic
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