Effects of Testosterone Administration on RNA Synthesis in Kidney of Castrated Rats

概要

論文の詳細を見る
Increase of RNA synthesis in the kidney of castrated rats was observed following testosterone administration. Using whole homogenates, the newly synthesized RNA in the kidney was found most abundantly three hrs. after testosterone administration, followed by a decrease, and returned to the previous level 24 hrs. later.<BR>Such newly synthesized RNA consists of both ribosomal RNA and DNA-like RNA, while scarcely any increase of synthesis was observed in soluble RNA. Before the increase in the new synthesis of RNA found in the kidney homogenates, increased synthesis of RNA was observed in the nuclei, mainly in ribosomal RNA. These facts might suggest a selective synthesis of ribosomal RNA in the nuclei in a certain stage, following testosterone administration.
社団法人日本内分泌学会の論文