Effects of Estrogen Administration on Testosterone-Induced Growth and Increase in Enzyme Activities in the Ventral Prostate of Castrated Rats
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概要
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Effects of estradiol -17β on testosterone-induced growth and increase in enzyme activities were studied in the ventral prostate of castrated rats. Estrogen administration did not affect testosterone induced growth of the atrophied tissue as determined by rates of increase in weight, the content of nucleic acids and DNA synthesis. However, cytoplasmic alkaline phosphatase activity was markedly increased by estrogen administration over the enzyme level of rats treated with testosterone alone. In rats treated simultaneously with androgen and estrogen throughout the experimental period, the synergistic effect on increase in the enzyme activity was observed to begin abruptly on the 6th day after initiation of the hormone treatment. This synergistic effect was found to be observed very clearly only in rats that received estrogen treatment during an early period of testosterone-induced recovery of the gland. Moreover, the observed synergism was found to be quite specific, since no effects of estrogen were detected on the enzyme levels of lactate, malate and isocitrate dehydrogenases or acid phosphatase in the tissue of testosterone-treated rats.
- 社団法人 日本内分泌学会の論文
著者
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Yamanaka Hidetoshi
Department Of Materials Science Osaka Electro-communication University
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SHIDA KEIZO
Department of Urology, Gunma University School of Medicine
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FURUYA NOBUO
Department of Urology, Gunma University School of Medicine
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Shimazaki Jun
Department Of Ophthalmology School Of Medicine Keio University
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SHIMAZAKI JUN
Department of Dermatology, School of Medicine, Chiba University
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SHIDA KEIZO
Department of Urology School of Medicine, Gunma University
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