Incorporation of Testosterone and 5α-Dihydrotestosterone into Rat Ventral Prostate <I>in vitro</I>
スポンサーリンク
概要
- 論文の詳細を見る
Incubations of rat ventral prostate with testosterone-14C and 5a-dihydrotestosterone (5α-androstane-17β-ol-3-one)-<SUP>3</SUP>H revealed the gradual increase in uptake of both steroids into the tissue. Ratios of <SUP>3</SUP>H/<SUP>14</SUP>C of the incorporated steroids were similar during the incubation periods, and this indicated that incorporation of both the steroids proceeded in the same pattern. Radioactivity in purified 5α-dihydrotestosterone from the incubated whole tissues showed a gradual increase in both <SUP>14</SUP>C and <SUP>3</SUP>H, and <SUP>3</SUP>H/<SUP>4</SUP>C ratio was also almost constant throughout the incubation period. Therefore, rate of the conversion of testosterone to 5α-dihydrotestosterone seems to be constant during the incubation.<BR>A considerable difference in <SUP>3</SUP>H/<SUP>14</SUP>C ratios of ethyl acetate extracts was observed between the various subcellular components after 30 min incubation. <SUP>3</SUP>H/<SUP>14</SUP>C ratio in 5α-dihydrotestosterone, however, showed a small difference in all subcellular components. Most of the radioactivity incorporated into purified nuclei was attached to 5adihydrotestosterone.
- 社団法人 日本内分泌学会の論文
著者
-
Shimazaki Jun
Department Of Ophthalmology Tokyo Dental College
-
SATO JIN
Department of Urology, Gunma University School of Medicine
-
Nagai Hisako
Department Of Biology Faculty Of Sciences Kyushu University
-
SHIDA KEIZO
Department of Urology, Gunma University School of Medicine
-
Shimazaki Jun
Department Of Ophthalmology School Of Medicine Keio University
-
Sato Jin
Department Of Urology Gunma Cancer Center
-
SHIMAZAKI JUN
Department of Dermatology, School of Medicine, Chiba University
-
SHIDA KEIZO
Department of Urology School of Medicine, Gunma University
-
SHIMAZAKI JUN
Department of Urology, Gunma University School of Medicine
-
SATO JIN
Department of Clinical Pathology and Metabolism, Dokkyo University School of Medicine
-
NAGAI HISAKO
Department of Urology, Gunma University School of Medicine
関連論文
- Three Distinct Commonly Deleted Regions of Chromosome Arm 16q in Human Primary and Metastatic Prostate Cancers
- Localization of a Tumor Suppressor Gene Associated With Progression of Human Prostate Cancer Within a 1.2 Mb Region of 8p22-p21.3
- Disposable Eyelid-Warming Device for the Treatment of Meibomian Gland Dysfunction
- Combined Medical and Surgical Treatment of Severe Vernal Keratoconjunctivitis
- Characteristics of Androgen-Independent Growth of Androgen-Responsive Shionogi Carcinoma 115 Cells
- Clinical Evaluation of Serum Prostate-Specific Antigen-Alpha^1-Antichymotrypsin Complex Values in Diagnosis of Prostate Cancer: A Cooperative Study
- PRLTS Gene Alterations in Human Prostate Cancer
- Microsatellite Instability and Other Molecular Abnormalities in Human Prostate Cancer
- Mutational Analysis of CDKN2 (CDK4I/MTS1) Gene in Tissues and Cell Lines of Human Prostate Cancer
- p53 Mutations Occur in Clinical, but Not Latent, Human Prostate Carcinoma
- Significance of prostate-specific antigen-doubling time on survival of patients with hormone refractory prostate cancer and bone metastasis : Analysis on 56 cases of cancer-specific death
- Comparison of Gleason grade and score between preoperative biopsy and prostatectomy specimens in prostate cancer
- Significance of capsular atachment and invasion of cancer tissues prostate cancer
- Change in the ratio of free-to-total prostate-specific antigen during progression of advanced prostate cancer
- Immunohistochemical finding of α-1-antichymotrypsin in tissues of benign prostatic hyperplasia and prostate cancer
- The Impact of HLA-A Matching in Corneal Transplantation
- Prostate-Specific Antigen Levels from a Mass Screening Program Using Highly Sensitive RIA Kits
- Surgical Approach to Tumor Thrombus of Renal Cell Carcinoma at the Level between Hepatic Vein and Diaphragm
- Endoscopic Treatment of Superficial Bladder Cancer with the Holmium : YAG (Ho : YAG) Laser
- Influence of Osteoarthritis on Serum Marker Levels of Bone Formation and Resorption in Patients with Benign Prostatic Hypertrophy
- Relationship between Prostate-Specific Antigen,Clinical Stage,and Degree of Bone Metastasis in Patients with Prostate Cancer:Comparison with Prostatic Acid Phosphatase and Alkaline Phosphatase
- DISEASE PROGRESSION IN STAGE A PROSTATE CANCER
- RADIATION THERAPY FOR PROSTATE CANCER CONFINED TO PELVIS
- DIURNAL RHYTHM OF SERUM γ-SEMINOPROTEIN IN PATIENTS WITH UNTREATED PROSTATE CANCER: COMPARISON OF THE ORIGINAL AND REVISED ASSAY KITS
- Significance of Measurement of Prostate Specific Antigen (PSA) in Familial Prostate Cancer Lines
- Microscopic polyangiitis after silicone breast implantation
- Relationship between Grade of Varicocele and the Response to Varicocelectomy
- EPIDEMIOLOGICAL CHARACTERISTICS OF PROSTATE CANCER IN GUNMA PREFECTURE, JAPAN
- Induction of Programmed Death/Apoptosis in Androgen-dependent Mouse Mammary Tumor Cell Line (Shionogi Carcinoma 115) by Androgen Withdrawal
- Treatment of Urinary Stones on an Outpatient Basis by Extracorporeal Shock Wave Lithotripsy using a EDAP LT-01 (+)
- Management of Candida albicans Donor-to-Host Transmission Following Penetrating Keratoplasty
- Changes in Cytosolic Androgen Receptor after Administration of Testosterone of Androgen-Dependent Mouse Mammary Tumor (Shionogi Carcinoma) and Its Sublines of Altered Androgen Dependency
- Low Molecular Weight Component of Androgen Receptor in Cytosols from Benign Hypertrophic Human Prostate treated with High KCl Solution
- Genetic structure and putative selective sweep in the pioneer tree, Zanthoxylum ailanthoides
- Properties and Androgen-Induced Changes of Arginase in Kidney and Ventral Prostate of Rats
- Effects of Testosterone Administration on RNA Synthesis in Kidney of Castrated Rats
- Effect of Sex Hormones on RNA Synthesis of Androgen-Dependent Mouse Mammary Tumor (Shionogi Carcinoma)
- Effects of Inhibitors of Nucleic Acids and Protein Biosynthesis on the Rate of 5α-reduction of Testosterone, the Activity of DNA Polymerase and Nucleic Acid Contents of Testosterone-stimulated Prostate of Rats
- Incorporation of Testosterone and 5α-Dihydrotestosterone into Rat Ventral Prostate in vitro
- Analysis of Multiple Primary Cancers in Patients with Urologic Cancer
- Solubilization of Testosterone 5α-Reductase from Nuclear Fraction of Rat Ventral Prostate
- Further Studies on Testosterone 5α-Reduction in Rat Ventral Prostate
- Inhibition of Nuclear Testosterone 5α-Reductase in Rat Ventral Prostate by Estrogens and Anti-Androgens
- Properties of Testosterone 5α-Reductase of Purified Nuclear Fraction from Ventral Prostate of Rats
- Surgical Management of Severe Canaliculitis Due to Intracanalicular Plug Migration Using Fish-Hook-Type Retractors : A Report of Two Patients
- Analysis of Estramustine Binding Protein (EBP) in Rat Dorsal Prostate by means of High Pressure Liquid Chromatography
- The Participation of Pituitary Gland in Estrogenic Effect on Arginase Activity in the Rat Prostates
- Binding to R 1881 (Methyltrienolone) of Proteins from Human Benign Prostatic Hypertrophy
- Free Amino Acids in the Caput and the Cauda Epididymis of Adult Rats
- Effect of Testosterone Administration on the Free Amino Acids and Conversion of Arginine to Proline and Glutamate in the Rat Ventral Prostate
- 3α-Reduction of 5α-Dihydrotestosterone by Rat Ventral Prostate
- Effects of Estrogen Administration on Testosterone-Induced Growth and Increase in Enzyme Activities in the Ventral Prostate of Castrated Rats
- Reduction of 5α-Position of Testosterone in the Rat Ventral Prostate
- Studies on Chromogranin Levels in Human Blood
- A New Serological Assay of Chromogranine
- Studies on the Relation between Dermatoses and Bacterial Allergy, with Special Reference to Micrococcus Pyogenes and Streptococcus Hemolyticus
- Binding of Chlormadinone Acetate to Cytosol from Human Benign Prostatic Hypertrophy
- Effect of AA560 (A Nonsteroidal Antiandrogen) Implantation In the Hypothalamus on Gonadotropin Secretion in Male Rats
- Effects of Antiprostatic Agents on 5α-Dihydrotestosterone Binding to Rat Hypophyseal and Hypothalamic Cytosol Macromolecules
- Effect of Hypolipidemia on Testosterone-Stimulated Prostatic Growth in Castrated Rats
- Effect of Estrogen Administration on Activities of Testosterone 5α-Reductase, Alkaline Phosphatase and Arginase in the Ventral and the Dorsolateral Prostates of Rats
- Correlation Analysis between Bladder Cancer and Cigarette Smoking in Various Countries
- Inhibition by Various Steroids on Dihydrotestosterone Binding to Androphilic Protein in Human Benign Prostatic Hypertrophy
- Androphilic Proteins in Cytosols of Human Benign Prostatic Hypertrophy
- Properties of Androphilic Proteins in Cytosols of Human Benign Prostatie Hypertrophy
- Dihydrotestosterone-binding protein in cytosols of normal and hypertrophic human prostates, and influence of estrogens and anti-androgens on the binding.
- Action of a novel nonsteroidal antiandrogen, AA560.
- Measurement of androgen receptor in cytosols from normal, benign hypertrophic and cancerous human prostates.
- Progestin-binding protein in human benign prostatic hypertrophy.
- Short-term effects of oral appliances with equal bite-raising distance but with varying protrusions on occlusal force, contact area and load center