Effects of X-Ray Irradiation on the Subsequent Gonadotropin Secretion in Normal and Neonatally Estrogenized Female Rats
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概要
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Female rats were irradiated with 190R of X-rays at 10 days of age and sacrificed 4, 7 or 12 months later. Their ovaries were histologically examined and serum levels and pituitary contents of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) were determined by radioimmunoassay. Both serum levels and pituitary contents of LH and FSH rose significantly 4 and 7 months after irradiation, although the ovaries were markedly reduced in weight. On the contrary, 12 months after irradiation, the ovaries increased in weight and consisted mostly of polyhedral, hyperplastic interstitial cell masses, and both LH and FSH in the serum and pituitary were reduced to normal levels.<BR>These characteristic changes in the ovarian weight and histological appearance could not be observed in the similarly irradiated animals which were received daily injections of estrone for the first 30 days of postnatal life, <I>i. e.</I>, daily injections of 50μg for the first 10 days, 100μg for the middle 10 days and 200μg for the last 10 days. Serum LH levels of the estrogenized irradiated rats at 7 or 12 months of age did not elevate although those of FSH were significantly higher than the non-irradiated intact levels.<BR>From these results, a rise in the blood levels of LH and FSH may be attributed to the increase in weight and the histological changes in the ovaries of the irradiated female rats, and the elevation of only FSH level may not result in the abnormal growth of the irradiated ovaries.
- 社団法人 日本内分泌学会の論文
著者
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MATSUMOTO Akira
Department of Microbiology, Kawasaki Medical School
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Wakabayashi Katsumi
Hormone Assay Center Institute of Endocrinology Gunma University
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ASAI TADASHI
Hormone Assay Center, Institute of Endocrinology, Gunma University
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Wakabayashi Katsumi
Hormone Assay Center Institute Of Endocrinology Gumma Univ.
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Asai Tadashi
Hormone Assay Center Institute Of Endocrinology Gunma University
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Matsumoto Akira
Department Of Aeronautics And Astronautics Faculty Of Engineering Kyushu University
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