Distribution of a Human Brain Carboxypeptidase B Capable of Cleaving β-Amyloid Precursor Protein(APP) in Normal and Alzheimer's Diseased Brain

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概要

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• The processing of β-amyloid precursor protein(APP) is considered critical for understanding the pathogenesis of Alzheimer's disease(AD). To elucidate the significance of APP processing enzyme, we studied immunohistochemically the distribution of APP-processing protease (human carboxypeptidase B : HBCPB) in the normal control brains and AD brains, using anti-C14 antibody which recognizes C-terminal 14 amino acids of HBCPB. In the control brains, intense and diffuse C14-immunoreactivity was observed in the cytoplasm of pyramidal neurons of the hippocampus. Moderate immunoreactivity was found in the cortical and subcortical neurons. In AD brains, C14-immunoreactivity was markedly decreased in the brain regions examined except for the brain stem and cerebellum. However, HBCPB was shown to be colocalized with β-amyloid protein(Aβ) in neuritic plaques. In addition, neuritic plaques included C14-immunoreactive microglia/macrophages. Our present studies indicate that the expression of a novel APP-processing protease is impaired in AD brains and may suggest the possible role of HBCPB in the pathogenesis of AD.

• 日本組織細胞化学会の論文

著者

• MATSUMOTO Akira

  Department of Microbiology, Kawasaki Medical School

• Itoh Kyoko

  Department Of Pathology And Applied Neurobiology Graduate School Of Medical Science Kyoto Prefectura

• Itoh Kyoko

  Department Of Pathology Kobe University School Of Medicine

• Matsumoto Akira

  Department Of Anatomy Juntendo University School Of Medicine

• Matsumoto Akira

  Department Of Radiation Biophysics & Genetics Kobe University School Of Medicine

• Matsumoto Akira

  Department Of Aeronautics And Astronautics Faculty Of Engineering Kyushu University

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