Prenatal Low-dose X-irradiation Affects Connexins 43 and 26 in Developing Mouse Neocortex
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概要
- 論文の詳細を見る
To investigate the effects of low-dose X-irradiation on the expression of connexins (Cxs) in developing cerebral cortex, C57/BL6 pregnant mice were exposed to whole body irradiation of 0.1 Gy and 0.5 Gy, on embryonic day 14.5. Fetal telencephalons, at 1, 3, 12 and 24 hr after exposure, were studied immunohistochemically using anti-Cx43 and Cx26 antibodies, followed by quantitative image analyses. Cx43 expression was significantly reduced in all zones of developing cerebral cortex until 12 hr after exposure, and tended to recover to control level after 24 hr. Cx26 expression was also suppressed in the ventricular zone and cortical plate after irradiation, although it recovered much earlier. Our observations indicate that the expression of Cxs is affected by ionizing radiation during cortical histogenesis.
- 日本組織細胞化学会の論文
著者
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Ohta Yoshimi
Department of Medical Technology, School of Health Sciences, Faculty of Medicine, Niigata University
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FUSHIKI SHINJI
Department of Clinical Pathology, Kyoto Prefectural University of Medicine
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Itoh Kyoko
Department of Pathology and Applied Neurobiology, Graduate School of Medical Science, Kyoto Prefectu
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Yaoi Takeshi
Department of Pathology and Applied Neurobiology, Graduate School of Medical Science, Kyoto Prefectu
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Fushiki S
Department Of Pathology And Applied Neurobiology Kyoto Prefectural University Of Medicine Graduate S
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Fushiki Shinji
Department Of Clinical Pathology Kyoto Prefectural University Of Medicine:department Of Pathology Ky
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FUJIWARA Yasuhiro
Department of Gastroenterology, Osaka City University Graduate School of Medicine
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Ohta Yoshimi
Department Of Pathology And Applied Neurobiology Graduate School Of Medical Science Kyoto Prefectura
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NOJIMA Kumie
International Space Radiation Laboratory
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Nojima Kumie
International Space And Radiation Laboratory National Institute Of Radiological Sciences
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Yamanaka Takumi
Department of Pathology and Applied Neurobiology, Kyoto Prefectural University of Medicine
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Mineura Katsuyoshi
Department of Neurosurgery, Graduate School of Medical Science, Kyoto Prefectural University of Medi
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Yamanaka Takumi
Department Of Pathology And Applied Neurobiology Kyoto Prefectural University Of Medicine:department
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Fujiwara Yasuhiro
Department Of Gastroenterology Osaka City University Graduate School Of Medicine
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Mineura Katsuyoshi
Department Of Neurosurgery Graduate School Of Medical Science Kyoto Prefectural University Of Medici
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Ohta Yoshimi
Department Of Cardiology Saiseikai Kurihashi Hospital
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Itoh Kyoko
Department Of Pathology And Applied Neurobiology Kyoto Prefectural University Of Medicine Graduate S
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Yaoi Takeshi
Department Of Pathology And Applied Neurobiology Kyoto Prefectural University Of Medicine Graduate S
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Yaoi Takeshi
Department Of Pathology And Applied Neurobiology Graduate School Of Medical Science Kyoto Prefectura
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Itoh Kyoko
Department Of Pathology And Applied Neurobiology Graduate School Of Medical Science Kyoto Prefectura
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Fujiwara Yasuhiro
Department Of Pathology And Applied Neurobiology Kyoto Prefectural University Of Medicine Graduate S
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Fujiwara Yasuhiro
Department of Breast Oncology and Medical Oncology, National Cancer Center Hospital
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Yaoi Takeshi
Department of Pathology & Applied Neurobiology, Kyoto Prefectural University of Medicine
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