Effects of Continuous Low-Dose Prenatal Irradiation on Neuronal Migration in Mouse Cerebral Cortex
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概要
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We investigated the effects of continuous exposure to γ-rays during corticogenesis on the migration of neuronal cells in developing cerebral cortex. Pregnant mice were injected with 0.5 mg of bromodeoxyuridine (BrdU) on day 14 of gestation to label cells in the S phase. The mice were then exposed to ^<137>Cs γ-rays (dose rates of 0.1, 0.3, and 0.94 Gy/day) continuously for 3 days. Brains from 17-day-old embryos and from offspring at 3 and 8 weeks after birth were processed immunohistochemically to track the movements of BrdU-labeled cells. Comparative analyses of the distribution pattern of BrdU-labeled cells in the cerebral cortex revealed that (1) the migration of neurons was delayed during the embryonic period in mice irradiated at 0.94 Gy/day, (2) in 3-week-old mice, there was a significant difference in the distribution pattern of BrdU-labeled cells in the cerebral cortex between the mice irradiated prenatally and control, and (3) in 8-week-old mice, there were no differences in the distribution pattern of BrdU-labeled cells between control and animals irradiated with 0.1 and 0.3 Gy/day. In contrast, in the animals irradiated with 0.94 Gy/day, the significant difference in the distribution pattern of the labeled cells relative to control was maintained. These results suggest that the migration of neuronal cells in mouse cerebral cortex is disturbed by continuous prenatal irradiation at low-dose and some modificational process occurred during the postnatal period.
- 日本放射線影響学会の論文
著者
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FUSHIKI SHINJI
Department of Clinical Pathology, Kyoto Prefectural University of Medicine
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Ishikawa Yuji
Environmental Radiation Effects Research Group Research Center For Radiation Protection National Ins
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Fushiki Shinji
Department Of Clinical Pathology Kyoto Prefectural University Of Medicine:department Of Pathology Ky
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HIROBE Tomohisa
Division of Biology, National Institute of Radiological Sciences
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Ishikawa Yuji
Department Of Applied Biological Science School Of Agriculture Nagoya University
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Ishikawa Yuji
Division of Biology, National Institute of Radiological Sciences
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Hyodo-Taguchi Yasuko
Division of Biology, National Institute of Radiological Sciences
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Kinoshita Chikako
Department of Pathology and Applied Neurobiology, Research Institute for Neurological Diseases and G
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Fushiki S
Department Of Pathology And Applied Neurobiology Graduate School Of Medical Science Kyoto Prefectual
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HYODO-TAGUCHI Yasuko
National Institute of Radiological Sciences
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Hyodo‐taguchi Y
National Institute Of Radiological Sciences
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Hyodo-taguchi Yasuko
Division Of Biology And Oncology National Institute Of Radiological Sciences
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Hirobe T
National Inst. Radiological Sci. Chiba Jpn
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Hirobe Tomohisa
Division Of Biology National Institute Of Radiological Sciences
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Ishikawa Yuji
Division Of Biology National Institute Of Radiological Sciences
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Kinoshita C
Kyoto Prefectural Univ. Medicine Kyoto Jpn
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Kinoshita Chikako
Department Of Dynamic Pathology Research Institute For Neurological Diseases And Geriatrics Kyoto Pr
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Ishikawa Yuji
Environmental Radiation Effects Research Group Research Center For Radiation Protection National Ins
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HIROBE TOMOHISA
Division of Biology and Oncology, National Institute of Radiological Sciences
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