Dose-Response and Large Relative Biological Effectiveness of Fast Neutrons with Regard to Mouse Fetal Cerebral Neuron Apoptosis
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概要
- 論文の詳細を見る
To evaluate the relative biological effectiveness (RBE) of low doses of neutrons on fetal nervous development, [C57BL/6J×C3H/He] hybrid (B6C3F1) mice were exposed to cyclotron-derived fast neutrons with peak energy of 10 MeV (0.02-1.0 Gy) or ^<137>Cs-generated gamma-rays (0.1-2.0 Gy) on embryonic day 13.5. We then evaluated the incidence of neuronal apoptosis in the cerebral cortex 24 hours after irradiation. Neuronal apoptosis increased in a dose-dependent manner in both neutron- and gamma-ray-irradiated groups: even at the lowest dose, a minimal increase in the apoptotic index was noted in response to both types of radiation. The dose-response curves were best fitted to linear quadratic models, and the evaluated RBE was 9.8, which was considered to be large for a prenatal effect and acute tissue injury induced by a low dose of neutrons.
- 日本放射線影響学会の論文
- 2006-03-31
著者
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FUSHIKI SHINJI
Department of Clinical Pathology, Kyoto Prefectural University of Medicine
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Hiraoka Takeshi
Low Dose Radiation Effects Research Project National Institute Of Radiological Sciences
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OGIU Toshiaki
Low Dose Radiat. Eff. Res. Proj., NIRS
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ISHIDA Yuka
Low Dose Radiat. Eff. Res. Proj., NIRS
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OHMACHI Yasushi
Low Dose Radiat. Eff. Res. Proj., NIRS
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Oguri T
Hiroshima Univ. Fac. Medicine Hiroshima
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Oguri Tetsuya
Department Of Internal Medicine And Molecular Science Nagoya City University Graduate School Of Medi
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Oguri Tetsuya
Second Department Of Internal Medicine Hiroshima University Faculty Of Medicine
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Fushiki Shinji
Department Of Pathology And Applied Neurobiology Kyoto Prefectural University Of Medicine
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Fushiki Shinji
Department Of Clinical Pathology Kyoto Prefectural University Of Medicine:department Of Pathology Ky
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NAKATA Yukiko
Low Dose Radiat. Effect Project, NIRS
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Ishida Yuka
Low Dose Radiation Effects Research Project National Institute Of Radiological Sciences
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Nakata Yukiko
Low Dose Radiat. Effect Project Nirs
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Nakata Yukiko
Low Dose Radiation Effects Research Project National Institute Of Radiological Sciences:third Depart
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Ogiu Toshiaki
Low Dose Radiation Effects Research Project National Institute Of Radiological Sciences
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Ogiu Toshiaki
Low Dose Effects Research Project National Institute Of Radiological Sciences
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Ogiu T
National Institute Of Radiological Science
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Ogiu Toshiaki
Low Dose Radiation Effect Project National Institute Of Radiological Sciences
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Ogiu Toshiaki
Low Dose Radiat. Effect Project. Natl. Inst. Radiol. Sci.
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Ohmachi Yasusi
Low Dose Radiation Effects Research Project National Institute Of Radiological Sciences
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Ohmachi Yasushi
Low Dose Effects Research Project National Institute Of Radiological Sciences
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Hamano Tsuyoshi
Low Dose Radiation Effects Research Project National Institute Of Radiological Sciences:department O
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Hamano Tsuyoshi
Low Dose Effects Research Project National Institute Of Radiological Sciences
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Oguri Tetsuya
Department Of Medical Oncology And Immunology Nagoya City University Graduate School Of Medical Scie
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