Neurobehavioral Changes in Mice Exposed to Fast Neutrons in utero
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概要
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Epidemiological studies have revealed that radiation causes brain development abnormalities in atomic bomb survivors exposed in utero. Rat and mouse studies have also shown that prenatal exposure to low-linear energy transfer radiation induces developmental brain anomalies. Because the effects of prenatal irradiation on adult behavior patterns remain largely unknown, the present study investigated the effects of neutron exposure in utero on postnatal behavior patterns in mice. [C57BL/6J × C3H/He] hybrid (B6C3F1) mice were exposed to cyclotron-derived fast neutrons with peak energy of 10 MeV (0.02–0.2 Gy) or Cs-137 gamma-rays (0.2–1.5 Gy) on embryonic day 13.5. At 5.5–8 months of age, the neurobehavior of male offspring was examined by Rota-rod treadmill and locomotor activity. The accumulation of radio-labeled drug at muscarinic acetylcholine and serotonin receptors in mice from control and neutron-irradiated groups was determined by the tracer method. Locomotor activity during the dark period increased in the 0.02 Gy neutron-irradiated group. Furthermore, at 5.5 months of age, tracer binding in vivo to the muscarinic acetylcholine increased and to the serotonin receptors decreased in the 0.02 Gy neutron-irradiated group. In conclusion, the present study reveals that a certain "low-dose window" may exist for radiation-induced changes in neurobehavior and binding to neurotransmitter receptors, because there was correlation in neurobehavior and binding to neurotransmitter receptors in the 0.02 Gy neutron-irradiated group though there was not correlation in the neutron-irradiated groups more than 0.05 Gy.
著者
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Shimada Yoshiya
Experimental Radiobiology For Children's Health Research Group Research Center For Radiation Pr
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Ishida Yuka
Low Dose Radiation Effects Research Project National Institute Of Radiological Sciences
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Ohmachi Yasusi
Low Dose Radiation Effects Research Project National Institute Of Radiological Sciences
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Ohmachi Yasushi
Low Dose Effects Research Project National Institute Of Radiological Sciences
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ISHIDA Yuka
Department of Technical Support and Development, Fundamental Technology Center, National Institute o
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OHMACHI Yasushi
Department of Radiation Dosimetry, Research Center for Radiation Emergency Medicine, National Instit
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TAKAI Nobuhiko
Division of Analytical Chemistry, Department of Pharmaceutical Sciences, Nagasaki International Univ
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HIRAOKA Takeshi
Technical Advancement of Radiation Systems Section, National Institute of Radiological Sciences
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OGIU Toshiaki
Office of International Affairs, Radiation Effects Association
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NISHIKAWA Tetsu
Department of Technical Support and Development, Fundamental Technology Center, National Institute o
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NISHIMURA Yoshikazu
Department of Technical Support and Development, Fundamental Technology Center, National Institute o
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