Postnatal Changes in Mice Exposed In Utero to Fast Neutrons
スポンサーリンク
概要
- 論文の詳細を見る
Exposure to radiation during brain development stage cause microcephaly or mental retardation. Although X- and gamma-rays induced cerebral hypoplasia in rodents has been well characterized, little is known about such effects of neutrons. To examine the effects of prenatal exposure to neutrons on the development of brain and other organs, both male and female B6C3F1 mice were irradiated with fast neutrons (0.1, 0.2, 0.5, 1 Gy) or gamma-rays (0.8, 1.5 Gy) at embryonic day 13.5, and the animals were examined histopathologically 56 days after birth. Both types of radiation mainly caused hypoplasia of the cerebral cortex and lowered brain absolute weight. No sex differences were seen. These changes were remarkable in each highest dose group. The weight loss of the brain was noted at the lowest dose group of neutrons. In addition, the weight loss of the thymus, atrophy of the seminiferous tubules, and a decrease in follicles of the ovary were also noted in the higher dose groups of neutrons and gamma-rays. The degrees of these changes were larger for neutrons.
- 日本毒性病理学会の論文
- 2004-03-30
著者
-
FUSHIKI SHINJI
Department of Clinical Pathology, Kyoto Prefectural University of Medicine
-
Hiraoka Takeshi
Low Dose Radiation Effects Research Project National Institute Of Radiological Sciences
-
OGIU Toshiaki
Low Dose Radiat. Eff. Res. Proj., NIRS
-
ISHIDA Yuka
Low Dose Radiat. Eff. Res. Proj., NIRS
-
OHMACHI Yasushi
Low Dose Radiat. Eff. Res. Proj., NIRS
-
Oguri T
Hiroshima Univ. Fac. Medicine Hiroshima
-
Oguri Tetsuya
Department Of Internal Medicine And Molecular Science Nagoya City University Graduate School Of Medi
-
Oguri Tetsuya
Second Department Of Internal Medicine Hiroshima University Faculty Of Medicine
-
Fushiki Shinji
Department Of Pathology And Applied Neurobiology Kyoto Prefectural University Of Medicine
-
Fushiki Shinji
Department Of Clinical Pathology Kyoto Prefectural University Of Medicine:department Of Pathology Ky
-
Ishida Yuka
Low Dose Radiation Effects Research Project National Institute Of Radiological Sciences
-
Ogiu Toshiaki
Low Dose Radiation Effects Research Project National Institute Of Radiological Sciences
-
Ogiu Toshiaki
Low Dose Effects Research Project National Institute Of Radiological Sciences
-
Ogiu T
National Institute Of Radiological Science
-
Ogiu Toshiaki
Low Dose Radiation Effect Project National Institute Of Radiological Sciences
-
Ogiu Toshiaki
Low Dose Radiat. Effect Project. Natl. Inst. Radiol. Sci.
-
Ohmachi Yasusi
Low Dose Radiation Effects Research Project National Institute Of Radiological Sciences
-
Ohmachi Yasushi
Low Dose Effects Research Project National Institute Of Radiological Sciences
-
Hamano Tsuyoshi
Low Dose Radiation Effects Research Project National Institute Of Radiological Sciences:department O
-
Hamano Tsuyoshi
Low Dose Effects Research Project National Institute Of Radiological Sciences
-
Oguri Tetsuya
Department Of Medical Oncology And Immunology Nagoya City University Graduate School Of Medical Scie
関連論文
- APPLICATION OF MICROWAVE IRRADIATION IN SURGICAL PATHOLOGY; IMPROVEMENT OF MICROSCOPIC-IMAGE OF CRYOSTAT SECTIONS AND EXPLORATION IN RAPID METALLIC STAININGS (Microwave Fixation in Histochemistry)
- MCL1 inhibits apoptotic cell death in hematopoietic cells after exposure to gamma-rays or etoposide
- Prenatal and Lactational Exposure to Bisphenol A in Mice Alters Expression of Genes Involved in Cortical Barrel Development without Morphological Changes
- 193 Radiosensitivity of the LEC rat(Mutation, Abstracts of the 46th Annual Meeting of the Japan Radiation Research Society)
- Genetic Susceptibility to Thymic Lymphomas and K-Ras Mutation in Mice after Exposure to X-rays and N-Ethyl-N-Nitrosourea
- Age dependency of the mechanism of radiogenic thymic lymphomas in B6C3F1 mice
- Differences of Molecular Alteration between Radiation-Induced and N-Ethyl-N-Nitrosourea-Induced ThymicLymphomas in B6C3F1 Mice.
- Multiple inactivation pathways of Ikaros, a potent tumor suppressor gene, in primary murine T-cell leukemia
- Age-dependent susceptibility to radiation thymic lymphomagenesis
- Diverse spectrum of K-ras mutation and its association with loss of heterozygosity on chromosome 6 in X-ray-induced thymic lymphomas of B6C3F1 mice.
- Point mutation in PU. 1 in radiation-induced mouse myeloidleukemia(Blood, Biomarker, Proceedings of the 32nd Annual Meeting)
- Differential Expression of DNA Topoisomerase IIα and IIβ Genes between Small Cell and Non-small Cell Lung Cancer
- Tumor Induction in Mice Locally Irradiated with Carbon Ions : A Retrospective Analysis
- Altered expression of transcriptional factors in thymic lymphomas induced by X-rays in B6C3F1 mice
- Loss of heterozigosity and Hras mutations in X-ray-induced B6C3F1 mouse liver tumors
- Lysophospholipid Receptors Are Differentially Expressed in Rat Terminal Schwann Cells, As Revealed by a Single Cell RT-PCR and In Situ Hybridization
- Genetic Effects of Radiation in Atomic-bomb Survivors and Their Children : Past, Present and Future
- IA-07 Spatiotemporal patterns of expression of IGSF4 in developing mouse nervous system(THE 46TH ANNUAL MEETING OF THE JAPAN SOCIETY OF HISTOCHEMISTRY AND CYTOCHEMISTRY)
- Prenatal Low-dose X-irradiation Affects Connexins 43 and 26 in Developing Mouse Neocortex
- Overexpression of carboxylesterase-2 results in enhanced efficacy of topoisomerase I inhibitor, irinotecan (CPT-11), for multiple myeloma
- Evaluation of radiation-induced brain developmental effect by neuronal apoptosis in mouse fetus(Development, Reproduction, Proceedings of the 32nd Annual Meeting)
- 194 Radiation-induced Germ-line Mutations Detected by a Direct Comparison of Parents and Children DNA Sequences Containing SNPs(Mutation, Abstracts of the 46th Annual Meeting of the Japan Radiation Research Society)
- 34 Dose-response Relationship of Thymic Lymphoma Induction by Gamma Radiation and Induction of Nonthymic Lymphomas at Very Low Doses in SCID Mice(Radiation carcinogenesis, Abstracts of the 46th Annual Meeting of the Japan Radiation Research Society)
- Analysis of Radiation-induced Germline Mutation Using SNP Marker
- Long-Term Organotypic Slice Culture of the Neonatal Mouse Liver
- Genomi-wide Analysis of the Loss of Heterozygosity in Radiation-induced Thymic Lymphomas of Scid Mice
- Selection of thymocytes susceprible for interleukins 7 and 9 at preleukemic stage in split-dose irradiated B6C3F1mice.
- Role of ABCG2 as a biomarker for predicting resistance to CPT-11/SN-38 in lung cancer
- Spontaneous Hepatic Rupture due to Metastatic Tumor of Lung Adenocarcinoma
- Determinants of sensitivity and resistance to gemcitabine : The roles of human equilibrative nucleoside transporter 1 and deoxycytidine kinase in non-small cell lung cancer
- Sequential expression of T-cell growth factor receptors on T-cell subsets in the development of thymic lymphomas after X-ray exposure to B6C3F1 mice
- Expression of Drug Resistance-related Genes in Head and Neck Squamous Cell Carcinoma and Normal Mucosa
- Comparison of Tumorigenesis between Accelerated Heavy Ion and X-ray in B6C3F1 Mice
- The study on RBE of heavy ions in mice. II.
- Cloning of a novel cDNA encoding a transcription factor protein induced by exposure to ionizing radiation
- Tumotigenicity of heavy iron and X-ray in B6C3F1 mice.
- Molecular cloning of the genes expressed by VEGF-stimulation involved in the suppression of apoptosis induced by ionizing radiation
- Tissue culture sture study on neuronal migration in the rat cerebral cortex; effects of low dose radiation
- Contrasting Effects of Angiotensin Type 1 and 2 Receptors on Nitric Oxide Release under Pressure
- Tumor induction in mouse legs after irradiation with heavy ions
- Neurobehavioral Changes in Mice Exposed to Fast Neutrons in utero
- Effects of pre- and neonatal exposure to bisphenol A on murine brain development
- IA-01 Molecular changes in neurons of rat nucleus ambiguus after axotomy, as revealed by an in vivo fluorescence neuronal labeling combined with a single-cell RT-PCR(THE 46TH ANNUAL MEETING OF THE JAPAN SOCIETY OF HISTOCHEMISTRY AND CYTOCHEMISTRY)
- Molecular Changes in Neurons of Rat Nucleus Ambiguus after Axotomy, As Revealed by a Novel Method of In Vivo Fluorescence Neuronal Labeling Combined with Single-cell RT-PCR
- The Effects of Heavy Ion Particles on the Developing Murine Cerebellum, with Special Reference to Cell Death
- Mechanisms of Deletion Formation in Notch1 Gene in Radiation-Induced Mouse Thymic Lymphomas
- Radiation-induced Thymic Lymphomagenesis in RAG2-deficient SCID Mouse
- A study of the expression of cell-cell junction components in radiation-induced rat breast cancer tissues
- Notch1 Functions as a Major Oncogene in Radiation-induced Mouse Thymic Lymphomas
- Effects of the Genetic Backgrounds on the Radiation Sensitivity and Carcinogenesis in Scid Mice
- Insertion of Intracisternal A Particle into Notchl Gene in Radiation-Induced Thymic Lymphomas of Scid Mice
- Intracisternal A paeticle (IAP) - mediated activation of the interleukin 2 receptor β chain (IL-2R β) gene in a radiation-induced scid mouse thymic lymphoma
- Effects of Scid Mutation on Radiation Carcinogenesis - Modification of Radiation Carcinogenesis by A Genetic Factor -
- Effects of Bone Marrow Transplantation on the Radiation Induceduction of Thymic Lymphomas in Scid Mice
- High Incidence of DNA Rearrangements of Oncogene Notch 1 in Radiation-Induced Thymic Lymphomas of Scid Mice
- Low Frequency of K-ras Mutation in Radiation-Induced Thymic Lymphomas of Scid Mice.
- Mutation of minisatellite, Pc-1, in Thymic Lyniphoinas Induced by X-Rays or N-Ethyl-N-nitrosourea in B6C3F_1 Mice
- Radiation-Induced Brain Cell Death Can Be Observed in Living Medaka Embryos
- Effects of Low-Dose X-Irradiation on the Development of the Mouse Cerebellar Cortex
- Effects of Continuous Low-Dose Prenatal Irradiation on Neuronal Migration in Mouse Cerebral Cortex
- Significance of thymidylate synthase for resistance to pemetrexed in lung cancer
- Differential Expression of Facilitative Glucose Transporter (GLUT) Genes in Primary Lung Cancers and Their Liver Metastases
- Identification of the Core Protein Carrying the Tn Antigen in Mouse Brain: Specific Expression on Syndecan-3
- Changes in Nitric Oxide Synthas-Containing Neurons in the Brain of Thiamine-Deficient Mice
- Diverse Spectrum of ras Mutations in Radiation-Induced Thymic Lymphomas.
- SGLT Gene Expression in Primary Lung Cancers and Their Metastatic Lesions
- Estrogen and Non-Feminizing Estrogen for Alzheimer's Disease
- Dose-Response and Large Relative Biological Effectiveness of Fast Neutrons with Regard to Mouse Fetal Cerebral Neuron Apoptosis
- Postnatal Changes in Mice Exposed In Utero to Fast Neutrons
- 82 Preliminary evaluation of brain development in mice prenatally irradiated with fast neutron(Radiation sensitivities in cells & tissues, Abstracts of the 46th Annual Meeting of the Japan Radiation Research Society)
- 68 Analysis of apoptosis in the mouse fetal brain neurocytes induced by fast neutrons(Radiation sensitivities in cells & tissues, Abstracts of the 46th Annual Meeting of the Japan Radiation Research Society)
- Cyclooxygenase-2(COX-2) mRNA Expression Levels in Normal Lung Tissues and Non-small Cell Lung Cancers
- Enhanced expression of IL9 receptor on thymocytes in the development of thymic lymphomas in C.B-17scid/scid mice after X-ray exposure
- Relation of Leakiness and Development of Thymic Lymphomas in Radiosensitive C. B-17/scid Mice
- Thymic Lyinphomas Induced by γ-Ray or N-Ethyl-N-nitrosourea (ENU) in SCID Mice
- Effects of the Genetic Backgrounds on the Radiation Sensitivity and Carcinogenesis of Scid Mouse
- Intragenic Deletion of Oncogene Notchl in Radiation -Induced Thymic Lymphornas of scid Mice
- The Expression of p63 during Epidermal Remodeling in Psoriasis
- S-1-5 Neutrons Biological Effects Research in NIRS(Present and Future of Researches on Biological Effects of Neutrons, Abstracts of the 46th Annual Meeting of the Japan Radiation Research Society)
- 77 Construction of Radiobiology Animal Archives for Radiation Effects Study(Radiation sensitivities in cells & tissues, Abstracts of the 46th Annual Meeting of the Japan Radiation Research Society)
- Proliferative Capacity Persists Most Tenaciously in the Murine Proximal Rostral Migratory Stream
- ABCC11/MRP8 confers pemetrexed resistance in lung cancer
- Neurobehavioral Changes in Mice Exposed to Fast Neutrons in utero
- Histopathological Changes in the Detrusor Muscle Relation to Bladder Hypertrophy in BPH Patients
- Comparison of Cell Kinetics between the Boundary and the Interboundary Areas during Hindbrain Segmentation in the Chick Embryo
- Comparison of Sensitivity to Ionizing Radiation Among SCID, C.B-17 and Their F_1 Mice
- Expression of cytokine receptors on T-cell subsets during the development of thymic lymphomas after X-ray exposure to B6C3F1 mice
- Altered Expression of Transcription Factors in Thymic Lymphomas Induced by X-rays in B6C3F1 Mice
- Age-Related Changes of the Argyrophilic Nucleolar Organizer Regions in Mouse Neocortical Neurons
- An autopsy case of bathtub drowning in epilepsy
- A-5 A combined staining method for argyrophilic nucleolar organizer regions and for glial fibrillary acidic protein in astrocytes of human brain
- Analysis of Carcinogenic Target Cells in Mouse Thymic Lymphomas Induced by Ionizing Radiation or Chemical Carcinogen
- P-50 Retrograde labeling of rat vagal neurons innervating lung and stomach by the carbocyanine dye DiI
- WS2-4 Cell adhesion molecule L1 (L1-CAM) and L1-linked developmental disorders of the nervous system(THE 46TH ANNUAL MEETING OF THE JAPAN SOCIETY OF HISTOCHEMISTRY AND CYTOCHEMISTRY)
- X-Ray Lacks Thymic Lymphoma Inducing and Promoting Activities in Rats
- Matrix Cells Dissociated from the Mouse Forebrain Vesicle Reaggregate to Form Neural Tube-like Organoid Structures in vitro
- Preservation and Utilization of Materials from Studies on Radiation Effects and Points at Issue
- Cell-to-cell Interactions during Development of the Neocortex, with Special Reference to Neuronal Migration
- Prenatal and lactational exposure to low-doses of bisphenol A alters adult mice behavior
- Two Japanese CADASIL Families Exhibiting Notch3 Mutation R75P Not Involving Cysteine Residue