Changes in Extracellular Matrix Components of Bladder Detrusor in Relation to Bladder Hypertrophy and Compliance in Patients with Benign Prostatic Hyperplasia
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概要
- 論文の詳細を見る
The bladder hypertrophy caused by infravesical obstruction due to benign prostatic hyperplasia(BPH)often results in bladder dysfunction. Here we attempted to study morphometrically the histological changes in bladder detrusor with reference to extracellular matrix and to find the correlation of those changes with bladder hypertrophy. Ultrasound estimated bladder weight(UEBW)and urodynamic parameters were evaluated in 34 BPH patients(71.4±7.9 years)before surgery. Bladder wall samples were obtained at surgery and stained using Masson trichrome method and immunohistochemistry for collagen types I and III and fibronectin, followed by morphometric color image analysis system. UEBW, ratios of connective tissue-to-smooth muscle(c / m), collagen type III-immunoreactive area-to-collagen type I-immunoreactive area(collagen III / I)and fibronectin-immunoreactive area-non-immunoreactive area(f / n)ranged from 21.0 to 126.1g(47.9±25.4g), 12.9 to 53.3%(27.6±9.2%), 31.9 to 69.7%(46.5±8.0%)and 40.2 to 125.9%(59.8±15.9%), respectively. UEBW correlated with c / m(r=0.744, p<0.0001), collagen III / I(r=0.698, p<0.0001)and f / m(r=0.733, p<0.0001). Among urodynamic parameters, bladder compliance was the only one that correlated with c / m(r=0.673, p<0.0001), collagen III / I(r=0.475, p<0.05)and f / n(r=0.590, p<0.001). These results suggest that an abnormal increase of connective tissue accompanied with increased levels of collagen type III and fibronectin could contribute to advanced bladder hypertrophy with a loss of elasticity of the bladder wall in patients with infravesical obstruction.
- 日本組織細胞化学会の論文
著者
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MIKI Tsuneharu
Department of Urology, Kyoto Prefectural University of Medicine Graduate School of Medical Science
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Ozasa K
Department Of Epidemiology For Community Health And Medicine Kyoto Prefectural University Of Medicin
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Ozasa Kotaro
京都府立医科大学 保健･予防医学教室
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Ozasa Kotaro
Department Of Social Medicine And Cultural Sciences Research Institute For Neurological Diseases And
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Yaoi Takeshi
Department of Pathology and Applied Neurobiology, Graduate School of Medical Science, Kyoto Prefectu
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MIYASHITA Hiroaki
Department of Integrated Medicine, Kagawa University
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Ukimura Osamu
Department of Pathology and Cell Regulation and Department of Urology, Kyoto Prefectural University
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Kojima Munekado
Department of Pathology and Cell Regulation and Department of Urology, Kyoto Prefectural University
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KAWAUCHI AKIHIRO
Department of Urology, Kyoto Prefectural University of Medicine
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KAMOI Kazumi
Department of Urology, Kyoto Prefectural University of Medicine
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MIYASHITA Hiroaki
Kyoto Prefectural University of Medicine Urological Oncology Research Group
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Kawata M
Department Of Anatomy And Neurobiology Kyoto Prefectural University Of Medicine
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Kawata Mituhiro
Department Of Anatomy And Neurobiology Kyoto Prefectural University Of Medicine
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Okada Koichi
Department Of Urology Kyoto Prefectural University Of Medicine
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Yaoi Takeshi
Department Of Urology Kyoto Prefectural University Of Medicine
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Yaoi Takeshi
Department Of Pathology And Applied Neurobiology Graduate School Of Medical Science Kyoto Prefectura
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Kamoi Kazumi
Department Of Urology Kyoto Prefectural University Of Medicine
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Ukimura Osamu
Department Of Urology Kyoto Prefectural University Of Medicine
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Iwata Tsuyoshi
Department Of Urology
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Iwata Tsuyoshi
Department Of Nettropsychiatry Gifu University School Of Medicine
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Kojima Munekado
Department Of Anatomy Kyoto Prefectural University Of Medicine
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Miki Tsuneharu
Department Of Urology Graduate School Of Medical Science Kyoto Prefectural University Of Medicine
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Ogawa Keiko
Department Of Public Health Tohoku University Graduate School Of Medicine
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Kamoi Kazumi
Department Of Urology Graduate School Of Medical Science Kyoto Prefectural University Of Medicine
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Inaba Mitsuhiko
Department of Urology
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Fushik Shinji
Department of Dynamic Pathology, Research Institute for Neurological Diseases and Geriatrics, Kyoto
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Okihar Koji
Department of Urology
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Inaba Mitsuhiko
Department Of Urology:department Of Dynamic Pathology Research Institute For Neurological Diseases A
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Kawauchi Akihiro
Department Of Pathology Osaka University Graduate School Of Medicine
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Fushik Shinji
Department Of Dynamic Pathology Research Institute For Neurological Diseases And Geriatrics Kyoto Pr
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Miyashita Hiroaki
Department Of Bioscience And Biotechnology
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Kawauchi Akihiro
Department Of Urology Kyoto Prefectural University Of Medicine
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Yaoi Takeshi
Department of Pathology & Applied Neurobiology, Kyoto Prefectural University of Medicine
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