Time Course of Reoxygenation in Experimental Murine Tumors after Carbon-beam and X-ray Irradiation

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概要

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• We compared the tumor reoxygenation patterns in three different murine tumor cell lines after X-irradiation with those after carbon-beam irradiation using a heavy-ion medical accelerator (HIMAC) system. The tumors of the cell lines SCCVII, SCCVII-variant-1 and EMT6 on the hind legs of mice received local priming irradiation with a carbon-beam (8 Gy, 73 keV/ μm in LET, 290 MeV/u, 6 cm SOBP) or X-rays (13 Gy, 250 kVp). After various intervals, the mice were given whole-body test irradiation (16 Gy, 250 kVp X-ray) either in air or after they were killed. The hypoxic fractions were estimated as the proportions of the surviving fractions of the tumors in killed mice to those in air-breathing mice. In the SCCVII tumors, the hypoxic fractions at 0.5 h were 50% and 21% (p < 0.05) after the priming X-irradiation and carbon-beam irradiation, respectively. In the SCCVII-variant-1 tumors, the hypoxic fractions were 85% and 82% at 0.5 h, 84% and 20% at 12 h (p < 0.01), and 21% and 31% at 24 h after X-ray and after carbon-beam irradiation, respectively. In the EMT6 tumors, the reoxygenation patterns after X-irradiation and carbon-beam irradiation were quite similar. We concluded that the reoxygenation pattern differed among the three tumor cell lines, and that reoxygenation tended to occur more rapidly after carbon-beam irradiation than after X-irradiation for SCCVII and SCCVII-variant-1 tumors.

• 日本放射線影響学会の論文

著者

• SHIBATA Toru

  Department of Radiology, Faculty of Medicine, Kyoto University

• 安藤 興一

  放射線医学総合研究所重粒子医科学センター粒子線生物研究グループ

• SHIBUYA Keiko

  Department of Therapeutic Radiology and Oncology, Kyoto University Graduate School of Medicine

• FURUSAWA Yoshiya

  National Institute of Radiological Sciences

• Futami Yasuyuki

  茨城県立医療大学 放射線技術科学科

• Futami Yasuyuki

  The Institute Of Physics University Of Tsukuba

• Futami Yasuyuki

  Dvisin Of Accelerator Physics And Engineering National Institite Of Radiological Sciences Chiba Japa

• Ando Koichi

  Heavy-ion Radiobiology Research Group National Institute Of Radiological Sciences

• SASAI Keisuke

  Department of Radilogy and Nuclear Medicine, Faculty of Medicine, Kyoto University

• HIRAOKA Masahiro

  Department of Radilogy and Nuclear Medicine, Faculty of Medicine, Kyoto University

• Sasai Keisuke

  Heavy-ion Radiobiology Research Group National Institute Of Radiological Sciences

• Nojima K

  National Inst. Radiological Sci. Chiba Jpn

• Shibuya Keiko

  Department Of Radiation Oncology And Image-applied Therapy Kyoto University Hospital

• Sasai Keisuke

  京都大学 放射腺腫瘍学･画像応用療学

• OYA Natsuo

  Department of Radiation Oncology and Image-applied Therapy, Graduate School of Medicine, Kyoto Unive

• NOJIMA Kumie

  International Space Radiation Laboratory

• KOIKE Sachiko

  International Space Radiation Laboratory

• ANDO Koichi

  International Space Radiation Laboratory

• FURUSAWA Yoshiya

  International Space Radiation Laboratory

• TAKAGI Takehisa

  Department of Radiology, Faculty of Medicine, Kyoto University

• Takagi Takehisa

  Department Of Therapeutic Radiology And Oncology Kyoto University Graduate School Of Medicine

• Nojima Kumie

  International Space And Radiation Laboratory National Institute Of Radiological Sciences

• Ando Koichi

  Department Of Technical Support And Development Natl. Inst. Radiol. Sci.

• Hiraoka Masahiro

  Department Of Radiology Kyoto University Hospital

• Ando Koichi

  Division Of Health Sciences Graduate School Of Medicine Osaka University

• Hiraoka Masahiro

  Department Of Pediatrics Fukui Medical School

• Oya Natsuo

  Department Of Radiation Oncology And Image-applied Therapy Graduate School Of Medicine Kyoto Univers

• Shibata Toru

  Department Of Therapeutic Radiology And Oncology Kyoto University Graduate School Of Medicine

• Shibata Toru

  Department Of Physics Aoyama Gakuin University

• Koike Sachiko

  Heavy-ion Radiobiology Research Group Research Center For Charged Particle Therapy National Institut

• Shibuya Keiko

  Department Of Radiation Oncology And Image-applied Therapy Kyoto University Graduate School Of Medic

• Sasai Keisuke

  Department Of Radiation Oncology Graduate School Of Medical And Dental Sciences Niigata University

• Shibata T

  Department Of Therapeutic Radiology And Oncology Kyoto University Graduate School Of Medicine

• Sasai Keisuke

  Department Of Radiation Oncology And Image-applied Therapy Kyoto University Graduate School Of Medic

• Takagi Takehisa

  Department Of Radiology Faculty Of Medicine Kyoto University

• FURUSAWA YOSHIYA

  International Space and Radiation Laboratory, National Institute of Radiological Sciences

• OYA NATSUO

  Department of Therapeutic Radiology and Oncology, Kyoto University Graduate School of Medicine

• SASAI KEISUKE

  Department of Therapeutic Radiology and Oncology, Kyoto University Graduate School of Medicine

• HIRAOKA MASAHIRO

  Department of Therapeutic Radiology and Oncology, Kyoto University Graduate School of Medicine

• KOIKE SACHIKO

  International Space and Radiation Laboratory, National Institute of Radiological Sciences

• ANDO KOICHI

  International Space and Radiation Laboratory, National Institute of Radiological Sciences

• Shibata Toru

  Department of Therapeutic Radiology and Oncology, Kyoto University Graduate School of Medicine

• NOJIMA KUMIE

  International Space and Radiation Laboratory, National Institute of Radiological Sciences

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