Effectiveness of Monoenergetic and Spread-Out Bragg Peak Carbon-Ions for Inactivation of Various Normal and Tumour Human Cell Lines
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概要
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This work aimed at measuring cell-killing effectiveness of monoenergetic and Spread-Out Bragg Peak (SOBP) carbon-ion beams in normal and tumour cells with different radiation sensitivity. Clonogenic survival was assayed in normal and tumour human cell lines exhibiting different radiosensitivity to X- or γ-rays following exposure to monoenergetic carbon-ion beams (incident LET 13-303keV/μm) and at various positions along the ionization curve of a therapeutic carbon-ion beam, corresponding to three dose averaged LET (LET_d) values (40,50 and 75keV/μm). Chinese hamster V79 cells were also used. Carbon-ion effectiveness for cell inactivation generally increased with LET for monoenergetic beams, with the largest gain in cell-killing obtained in the cells most radioresistant to X- or γ-rays. Such an increased effectiveness in cells less responsive to low LET radiation was found also for SOBP irradiation, but the latter was less effective compared with monoenergetic ion beams of the same LET. Our data show the superior effectiveness for cell-killing exhibited by carbon-ion beams compared to lower LET radiation, particularly in tumour cells radioresistant to X- or γ-rays, hence the advantage of using such beams in radiotherapy. The observed lower effectiveness of SOBP irradiation compared to monoenergetic carbon beam irradiation argues against the radiobiological equivalence between dose-averaged LET in a point in the SOBP and the corresponding monoenergetic beams.
- 日本放射線影響学会の論文
- 2008-11-16
著者
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Cherubini Roberto
Infn-laboratori Nazionali Di Legnaro
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FURUSAWA Yoshiya
National Institute of Radiological Sciences
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Futami Yasuyuki
The Institute Of Physics University Of Tsukuba
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Futami Yasuyuki
Dvisin Of Accelerator Physics And Engineering National Institite Of Radiological Sciences Chiba Japa
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Simone Giustina
Istituto Superiore Di Sanita:infn-sezione Di Romal-gruppo Collegato Di Sanita
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Esposito Giuseppe
Istituto Superiore Di Sanita:infn-sezione Di Romal-gruppo Collegato Di Sanita
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BELLI Mauro
Istituto Superiore di Sanita
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BETTEGA Daniela
Dipartimento di Fisica, Universita di Milano
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CALZOLARI Paola
Dipartimento di Fisica, Universita di Milano
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CUTTONE Giacomo
INFN-Laboratori Nazionali del Sud
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DURANTE Marco
Dipartimento di Scienze Fisiche, Universita Federico II
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GERARDI Silvia
INFN-Laboratori Nazionali di Legnaro
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GIALANELLA Giancarlo
Dipartimento di Scienze Fisiche, Universita Federico II
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GROSSI Gianfranco
Dipartimento di Scienze Fisiche, Universita Federico II
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MANTI Lorenzo
Dipartimento di Scienze Fisiche, Universita Federico II
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MARCHESINI Renato
Dipartimento di Fisica Medica, Fondazione IRCSS Istituto Nazionale dei Tumori
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PUGLIESE Mariagabriella
Dipartimento di Scienze Fisiche, Universita Federico II
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SCAMPOLI Paola
Dipartimento di Scienze Fisiche, Universita Federico II
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SORRENTINO Eugenio
Istituto Superiore di Sanita
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TABOCCHINI Maria
Istituto Superiore di Sanita
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TALLONE Lucia
Dipartimento di Fisica, Universita di Milano
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Belli Mauro
Istituto Superiore Di Sanita:infn-sezione Di Romal-gruppo Collegato Di Sanita
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Furusawa Y
Research Center For Charged Particle Therapy National Institute Of Radiological Sciences
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Tallone Lucia
Dipartimento Di Fisica Universita Di Milano:infn-sezione Di Milano
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Durante Marco
Gsi Biophysics Dep. And Technical Univ. Of Darmstadt
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Durante Marco
Dipartimento Di Scienze Fisiche Universita Federico Ii:infn-sezione Di Napoli
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Manti Lorenzo
Dipartimento Di Scienze Fisiche Universita Federico Ii:and Infn-sezione Di Napoli
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Scampoli Paola
Dipartimento Di Scienze Fisiche Universita Federico Ii:infn-sezione Di Napoli
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Grossi Gianfranco
Dipartimento Di Scienze Fisiche Universita Federico Ii:and Infn-sezione Di Napoli
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Calzolari Paola
Dipartimento Di Fisica Universita Di Milano:infn-sezione Di Milano
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Bettega Daniela
Dipartimento Di Fisica Universita Di Milano:infn-sezione Di Milano
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Tabocchini Maria
Istituto Superiore Di Sanita:infn-sezione Di Romal-gruppo Collegato Di Sanita
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Marchesini Renato
Dipartimento Di Fisica Medica Fondazione Ircss Istituto Nazionale Dei Tumori
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Gialanella Giancarlo
Dipartimento Di Scienze Fisiche Universita Federico Ii:infn-sezione Di Napoli
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Pugliese Mariagabriella
Dipartimento Di Scienze Fisiche Universita Federico Ii:infn-sezione Di Napoli
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Sorrentino Eugenio
Istituto Superiore Di Sanita:infn-sezione Di Romal-gruppo Collegato Di Sanita
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