Influence of the Shielding on the Induction of Chromosomal Aberrations in Human Lymphocytes Exposed to High-energy Iron Ions
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概要
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Computer code calculations based on biophysical models are commonly used to evaluate the effectiveness of shielding in reducing the biological damage caused by cosmic radiation in space flights. Biological measurements are urgently needed to benchmark the codes. We have measured the induction of chromosomal aberrations in human peripheral blood lymphocytes exposed in vitro to ^<56>Fe-ion beams accelerated at the HIMAC synchrotron in Chiba. Isolated lymphocytes were exposed to the 500 MeV/n iron beam (dose range 0.1-1 Gy) after traversal of 0 to 8 g/cm^2 of either PMMA (lucite, a common plastic material) or aluminum. Three PMMA shield thickness and one Al shield thickness were used. For comparison, cells were exposed to 200 MeV/n iron ions and to X-rays. Chromosomes were prematurely condensed by a phosphatase inhibitor (calyculin A) to avoid cell-cycle selection produced by the exposure to high-LET heavy ion beams. Aberrations were scored in chromosomes 1, 2, and 4 following fluorescence in situ hybridization. The yield of chromosomal aberrations per unit dose at the sample position was poorly dependent on the shield thickness and material. However, the yield of aberrations per unit ion incident on the shield was increased by the shielding. This increase is associated to the increased dose-rate measured behind the shield as compared to the direct beam. These preliminary results prove that shielding can increase the effectiveness of heavy ions, and the damage is dependent upon shield thickness and material.
- 日本放射線影響学会の論文
著者
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YASUDA Nakahiro
National Institute of Radiological Sciences
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KAWATA Tetsuya
Department of Radiology, Graduate School of Medicine, Chiba University
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FURUSAWA Yoshiya
National Institute of Radiological Sciences
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FUTAMI Yasuyuki
Shizuoka Cancer Center
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Futami Yasuyuki
茨城県立医療大学 放射線技術科学科
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Futami Yasuyuki
The Institute Of Physics University Of Tsukuba
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DURANTE Marco
Dipartimento di Scienze Fisiche, Universita Federico II
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GIALANELLA Giancarlo
Dipartimento di Scienze Fisiche, Universita Federico II
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GROSSI Gianfranco
Dipartimento di Scienze Fisiche, Universita Federico II
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PUGLIESE Mariagabriella
Dipartimento di Scienze Fisiche, Universita Federico II
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SCAMPOLI Paola
Dipartimento di Scienze Fisiche, Universita Federico II
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YASUDA Nakahiro
Natl Inst Radiol Sci
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Furusawa Y
Research Center For Charged Particle Therapy National Institute Of Radiological Sciences
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Durante Marco
Gsi Biophysics Dep. And Technical Univ. Of Darmstadt
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Durante Marco
Dipartimento Di Scienze Fisiche Universita Federico Ii:infn-sezione Di Napoli
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Scampoli Paola
Dipartimento Di Scienze Fisiche Universita Federico Ii:infn-sezione Di Napoli
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Grossi Gianfranco
Dipartimento Di Scienze Fisiche Universita Federico Ii:and Infn-sezione Di Napoli
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Kawata Tetsuya
Department Of Radiology Graduate School Of Medicine Chiba University
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Kawata Tetsuya
Department Of Internal Medicine Ii Hokkaido University School Of Medicine
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Gialanella Giancarlo
Dipartimento Di Scienze Fisiche Universita Federico Ii:infn-sezione Di Napoli
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Pugliese Mariagabriella
Dipartimento Di Scienze Fisiche Universita Federico Ii:infn-sezione Di Napoli
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Yasuda Nakahiro
National Institute of Radiological Science, Chiba 263-8555, Japan
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