Effects of Methamphetamine on Cortisone Concentration, NK Cell Activity and Mitogen Response of T-lymphocytes in Female Cynomolgus Monkeys
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概要
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As a model for studying methamphetamine (MAP) abuse, which has become a social problem in Japan, we investigated the changes in serum cortisone, NK cell activity and mitogenic response of T-lymphocytes after a single injection of MAP (3.0 mg/kg) in female cynomolgus monkeys. Serum cortisol concentration was significantly elevated to 2.66 times pre-injection levels at 6 h post-injection, and the effect was still observed 24 h later. NK cell activity was significantly elevated at 6 h after MAP injection, but at 24 h after injection had dropped markedly to 49.5% of baseline. Mitogen (PHA) response of lymphocytes was elevated when MAP was injected, and this increased level continued up to 24 h. We speculate that the transient increase in NK cell activity followed by a distinct drop, as well as the changes in T-lymphocytes, may be strongly related to the cortisone concentration.
- Japanese Association for Laboratory Animal Scienceの論文
著者
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KAWATA Tetsuya
Department of Radiology, Graduate School of Medicine, Chiba University
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Saito Toru
Behavioral Neuroscience Laboratory Graduate School Of Veterinary Medicine Nippon Veterinary And Life
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Terada Masaru
Department Of Legal Medicine Course Of Social Medicine Osaka University Graduate School Of Medicine
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Yokosuka Makoto
Behavioral Neuroscience Laboratory Graduate School Of Veterinary Medicine Nippon Veterinary And Life
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Kawata Tetsuya
Department Of Internal Medicine Ii Hokkaido University School Of Medicine
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Kanai Takao
Institute Of Laboratory Animals Tokyo Women's Medical University
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Saito Masayoshi
Department Of Laboratory Animal Science
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Ito Hisao
Departmen Of Radiology School Of Medicine Keio University
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ITO Hisao
Department of Radiology, Graduate School of Medicine, Chiba University
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YOKOSUKA Makoto
Behavioral Neuroscience Laboratory, Nippon Veterinary and Life Science University
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YAMAGUCHI Takao
Science Service Co., Ltd.
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