rdwラットの下垂体および副腎機能
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概要
- 論文の詳細を見る
The rdw rat is a hereditary hypothyroid strain isolated from Wistar-Imamichi rats. In the present study, adrenocorticotropic hormone (ACTH) and corticosterone responses to restraint stress (120 min) were examined in rdw adult male rats. ACTH response to restraint stress was higher in rdw rats than in hetero control rats. The plasma concentrations of corticosterone were lower in rdw rats than in control rats during the first 30 min after the onset of stress. Both ACTH and corticosterone responses to restraint stress in rdw rats recovered to control levels after thyroxine (T4) replacement therapy. These results suggest that hereditary hypothyroidism causes adrenal dysfunction directly and that hypersecretion of ACTH is a result of reduced corticosterone in rdw rats.
- 社団法人 日本実験動物学会の論文
- 2010-01-01
著者
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KANAI Takao
Institute of Lboratory Animals, Tokyo Women's Medical University
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KON Hiroe
Laboratory Animal Research Center, Dokkyo Medical University
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SHINODA Motoo
Laboratory Animal Research Center, Dokkyo Medical University
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Kon Hiroe
Lab. Animal Res. Center Dokkyo Medical Univ.
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Kon Hiroe
Laboratory Animal Research Center Dokkyo Medical University
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Shinoda Motoo
Lab. Animal Res. Center Dokkyo Medical Univ.
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Shinoda Motoo
Laboratory Animal Research Center Dokkyo Medical University
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UMEZU Motoaki
Laboratory of Animal Reproduction, Graduate School of Agricultural Science, Tohoku University
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TOHEI Atsushi
Laboratory Animal Research Center, Dokkyo University School of Medicine
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YAMAGUCHI Keiichiro
Department of Radiology, University of the Ryukyus School of Medicine
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Tohei A
Laboratory Animal Research Center Dokkyo University School Of Medicine
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Umezu Motoaki
Laboratory Of Animal Beproduction Faculty Of Agriculture Tohoku University
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Umezu Motoaki
Laboratory Of Animal Endocrinology And Reproduction Faculty Of Agriculture Utsunomiya University
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KOSAKU Akinori
Department of Pathology, Dokkyo Medical University Hospital
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Yamaguchi Keiichiro
Department Of Pathology Dokkyo Medical University Hospital
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Kanai Takao
Institute Of Laboratory Animals Tokyo Women's Medical University
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Kosaku Akinori
Department Of Pathology Dokkyo Medical University Hospital
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Kanai Takao
Inst. Of Lab. Animals Tokyo Women's Medical Univ.
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梅津 元昭
Laboratory of Animal Endocrinology and Reproduction, Faculty of Agriculture, Utsunomiya University
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藤平 篤志
Laboratory Animal Research Center, Dokkyo University School of Medicine
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金井 孝夫
Institute of Laboratory Animals, Tokyo Women's Medical University
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