免疫不全および免疫正常マウスに対するPasteurella pneumotropicaの病原性

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概要

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• Pasteurella pneumotropica is an opportunistic pathogen in rodents. Natural infection in immunodeficient animals suggests that immunodeficiency is a major factor in P. pneumotropica pathogenesis. To understand this process, we performed clinical, pathological and bacteriological studies of immunodeficient NOD/ShiJic-scid/Jcl and immunocompetent Crlj:CD1 (ICR) mice experimentally infected with P. pneumotropica ATCC 35149. From 14 days postinoculation, some of P. pneumotropica-infected NOD/ShiJic-scid/Jcl mice developed clinical signs of weight loss. Three of 10 P. pneumotropica-infected NOD/ShiJic-scid/Jcl mice developed clinical signs of depression, ruffled coat, and weight loss and died at 27, 34, and 59 days postinoculation. At 35 days postinoculation, almost all P. pneumotropica-infected NOD/ShiJic-scid/Jcl mice had lung abscesses. The bacteria were isolated from the upper and lower respiratory tracts, including the lungs, and blood. In contrast, P. pneumotropica-infected ICR mice exhibited no clinical signs or lesions. The bacteria were isolated from the upper, but not the lower respiratory tracts. We developed an animal model for understanding host interactions with P. pneumotropica.

• 社団法人　日本実験動物学会の論文

著者

• Takakura Akira

  Iclas Monitoring Center Central Institute For Experimental Animals

• Sasaki Hiraku

  Animal Research Center Tokyo Medical University

• HAYASHIMOTO Nobuhito

  ICLAS Monitoring Center, Central Institute for Experimental Animals

• Itoh Toshio

  Iclas Monitoring Center Central Institute For Experimental Animals

• Kawamoto Eiichi

  Animal Research Center Tokyo Medical University

• Okiyama Emi

  Animal Research Center Tokyo Medical University

• SAWADA Takuo

  Laboratory of Veterinary Microbiology, Nippon Veterinary and Life Science University

• Kanai Takao

  Institute Of Laboratory Animals Tokyo Women's Medical University

• Ueshiba Hidehiro

  Institute Of Laboratory Animals Tokyo Women's Medical University

• OHNISHI Naoko

  Institute of Laboratory Animals, Tokyo Women’s Medical University

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