Quarantine for Contaminated Pathogens in Transplantable Human Tumors or Infections in Tumor Bearing Mice
スポンサーリンク
概要
- 論文の詳細を見る
To quarantine human tumor samples for transplantation into immune deficient mice or tumor xenograft lines established and introduced from other institutions, we performed isolated implantation and passaging of tumors in a vinyl isolator, and microbiological examinations of sentinel mice kept together with tumor bearing mice. We examined 105 pairs of sentinel mice used to quarantine 907 tumors, and found six cases of contamination or infection with Staphylococcus aureus, 20 cases with Pseudomonas aeruginosa and one case with mouse hepatitis virus (MHV). It was, however, possible that Mycoplasma pulmonis contamination was overlooked because the microbe had been isolated from tumors passaged after quarantine, even though the results of the quarantine of these tumors showed no sign of pathogens. Direct culture of tumors for the microbe was recommended to improve the quarantine system.
- 社団法人 日本実験動物学会の論文
著者
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TAKAKURA Akira
ICLAS Monitoring Center, Central Institute for Experimental Animals
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Oishi Yumiko
Department Of Cardiology The University Of Tokyo
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Ohishi Yumiko
東京大学 医学系研究科循環器内科
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高倉 彰
財団法人実験動物中央研究所
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Takakura Akira
Iclas Monitoring Center Central Institute For Experimental Animals
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Takakura Akira
実験動物中央研究所 Iclasモニタリングセンター
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Ueyama Y
Dep. Of Pathology Tokai Univ. School Of Medicine
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Ueyama Y
Tokai Univ. School Of Medicine Kanagawa Jpn
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Ueyama Y
Tokai Univ. School Of Medicine Isehara‐shi Jpn
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Ueyama Yoshito
Department Of Pathology Tokai University School Of Medicine
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ITOH Toshio
Central Institute for Experimental Animals
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Itoh T
Central Inst. For Experimental Animals
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OHNISHI Yasuyuki
Central Institute for Experimental Animals
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YOSHIMURA Masumi
Central Institute for Experimental Animals
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YOSHIMURA Masumi
Laboratory of Oncology, Central Institute for Experimental Animals
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ENDO Sachio
Animal Resource Center, Central Institute for Experimental Animals
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ISHIHARA Ken-ichi
Laboratory of Oncology, Central Institute for Experimental Animals, Animal Care Inc.
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ITOH Toshio
ICLAS Monitoring Center, Central Institute for Experimental Animals
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UEYAMA Yoshito
Animal Care Inc.
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OHNISHI Yasuyuki
Laboratory of Oncology, Central Institute for Experimental Animals
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ENDO Sachio
Central Institute for Experimental Animals
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Itoh Toshio
Iclas Monitoring Center Central Institute For Experimental Animals
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Ohnishi Yasuyuki
Biomedical Research Department Central Institute For Experimental Animals
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Ohnishi Yasuyuki
Central Inst. For Experimental Animals
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Umezawa Y
Department Of Dermatology Tokai University School Of Medicine
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Yokosuka Makoto
Dep. Of Veterinary Biochemistry Fac. Of Veterinary Medicine Nippon Veterinary And Animal Sci. Univ.
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Ishihara Ken-ichi
Laboratory Of Oncology Central Institute For Experimental Animals Animal Care Inc.
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Ueyama Yoshihito
Department Of Pathology Tokai University School Of Medicine
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