アイソレーター飼育はC57BL/6JJclマウスにインシュリン抵抗性を引き起こす
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概要
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As basic probiotics studies, the glucose tolerance test (GTT), insulin tolerance test (ITT), and adipokine and hepatic enzyme activities were investigated in male C57BL/6JJcl (B6J) mice under germfree (GF) or specific pathogen free (SPF) conditions. GF B6J mice were reproduced by reproductive engineering and cesarean section using a vinyl isolators (GF group). Some GF group mice were transferred to other vinyl isolators under SPF conditions (SPF group). In addition, conventional B6J mice bred in an open room were defined as controls (Conv group). GTT, ITT, and the sampling of blood, liver, white adipose tissue, and pancreas were performed when these B6J mice were at the age of 8 weeks. As a result, the GF and SPF groups showed hyperglycemia, impaired glucose tolerance and insulin resistance when compared with the Conv group. The adipose tissues and plasma TNFα concentrations in the GF and SPF groups were enlarged and increased when compared with the Conv group. Hepatic enzyme activities associated with glucose uptake in the GF and SPF groups were higher than those in the Conv group. However, hepatic enzyme activities associated with gluconeogenesis in the GF and SPF groups were lower than those in the Conv group. We assumed that these results were reactions by the liver to recover from the impaired glucose tolerance and the insulin resistance caused by vinyl isolator breeding of the GF and SPF groups by control of glucose metabolism.
- 2011-10-01
著者
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斎藤 宗雄
財団法人実験動物中央研究所
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EBUKURO Susumu
Central Institute for Experimental Animals
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橋本 晴夫
Central Institute for Experimental Animals
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SUEMIZU Hiroshi
Central Institute for Experimental Animals
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Hioki Kyoji
Central Inst. For Experimental Animals
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高倉 彰
財団法人実験動物中央研究所
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Takakura Akira
実験動物中央研究所 Iclasモニタリングセンター
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齊藤 宗雄
財団法人実験動物中央研究所
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NOZU Ryoko
Central Institute for Experimental Animals
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SAITO Muneo
Central Institute for Experimental Animals
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KOSAKA Kinori
Central Institute for Experimental Animals
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Hashimoto Haruo
Central Inst. For Experimental Animals
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斉藤 宗男
実中研
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Arai Toshiro
Department Of Veterinary Biochemistry
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Ito M
Central Inst. For Experimental Animals
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Suemizu Hiroshi
Biomedical Research Department Central Institute For Experimental Animals
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Arai T
Dep. Of Veterinary Biochemistry Fac. Of Veterinary Medicine Nippon Veterinary And Animal Sci. Univ.
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Kawai Kenji
Central Institute For Experimental Animals
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Ito Mamoru
Central Inst. For Experimental Animals Kawasaki Jpn
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Mizusawa Takuma
Central Inst. For Experimental Animals
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Mizusawa Takuma
Central Institute For Experimental Animals
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UENO Masami
Central Institute for Experimental Animals
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HIRATA Hiroshi
Central Institute for Experimental Animals
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OGAWA Maya
Central Institute for Experimental Animals
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IMAI Kuniyasu
Central Institute for Experimental Animals
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HIGUCHI Yuichiro
Central Institute for Experimental Animals
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江袋 進
Central Institute for Experimental Animals
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野津 量子
Central Institute for Experimental Animals
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ARAI Toshiro
Department of Biochemistry, Nippon Veterinary and Animal Science University, 1-7-1 Kyonan-cho, Musashino-shi, Tokyo 180-8602, Japan
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