Evaluation of Serum and Urine 1,5-Anhydro-D-Glucitol and Myo-Inositol Concentrations in Healthy Dogs
スポンサーリンク
概要
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1,5-anhydro-D-glucitol (1,5AG) is a pyranoid polyol compound found in human circulating blood. Myo-inositol (MI) is a stereoisomer of inositol and serves as a precursor of inositol phospholipids. 1,5AG and MI are filtered by the glomerulus and almost completely reabsorbed through the renal tubules. However, under hyperglycemic conditions, reabsorption through the renal tubules is competitively inhibited because the structures of 1,5AG and MI resemble that of glucose. In this study, we investigated the kinetics of serum and urine 1,5AG and MI levels in healthy dogs. We demonstrated that 1,5AG and MI exist in canine serum and urine by gas chromatography-mass spectrometry. Under continuous hyperglycemic conditions, the serum 1,5AG concentration in healthy dogs decreased while the serum MI concentration remained unchanged. Urinary excretion of 1,5AG and MI increased significantly after blood glucose concentrations reached 200 to 220 mg/dl. A significant negative correlation was observed between serum 1,5AG and glucose concentrations during hyperglycemia. However, no significant correlation was observed between serum MI and glucose concentrations. In this study, we demonstrated that serum and urine 1,5AG and MI levels were changed by blood glucose concentrations. The serum 1,5AG concentration was decreased by continuous hyperglycemia. However, the serum MI concentration does not reflect hyperglycemia.
著者
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SAKO Toshinori
Department of Veterinary Nursing, School of Veterinary Nursing and Technology, Nippon Veterinary and
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MIKI Yohei
Department of Materials Science and Technology, Faculty of Science and Technology, Hirosaki Universi
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Tazaki Hiroyuki
Department Of Bioresource Chemistry Obihiro University Of Agriculture And Veterinary Medicine
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Mori Akihiro
Department Of Electric Engineering Faculty Of Engineering Kyoto University
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Arai Toshiro
Department Of Veterinary Biochemistry
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ISHIOKA Katsumi
Department of Veterinary Nursing, School of Veterinary Nursing and Technology, Faculty of Veterinary
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HAYAKAWA Noriyuki
Department of Veterinary Medical Teaching Hospital, Nippon Veterinary and Life Science University
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NIKI Tomoe
Department of Veterinary Nursing and Technology, Nippon Veterinary and Life Science University
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ODA Hitomi
Department of Veterinary Nursing and Technology, Nippon Veterinary and Life Science University
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SAEKI Kaori
Department of Veterinary Nursing and Technology, Nippon Veterinary and Life Science University
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SATO Toko
Department of Veterinary Science, School of Veterinary Medicine, Nippon Veterinary and Life Science
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Ishioka Katsumi
Department Of Physiology Faculty Of Veterinary Medicine Hokkaido University
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Mori Akihiro
School Of Veterinary Nursing And Technology Faculty Of Veterinary Science Nippon Veterinary And Life
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HAYAKAWA Noriyuki
Veterinary Medical Teaching Hospital, Nippon Veterinary and Life Science University
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Miki Yohei
School Of Veterinary Nursing And Technology Faculty Of Veterinary Science Nippon Veterinary And Life Science University
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TAZAKI Hiroyuki
Department of Agricultural Chemistry, Faculty of Agriculture, Hokkaido University
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SAKO Toshinori
Department of Veterinary Nursing & Technology, School of Veterinary Science, Nippon Veterinary and Life Science University, 1–7–1 Kyonancho, Musashino, Tokyo 180–8602, Japan
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ARAI Toshiro
Department of Biochemistry, Nippon Veterinary and Animal Science University, 1-7-1 Kyonan-cho, Musashino-shi, Tokyo 180-8602, Japan
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TAZAKI Hiroyuki
Department of Veterinary Science, School of Veterinary Medicine, Nippon Veterinary and Life Science University
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MIKI Yohei
Department of Veterinary Nursing and Technology, Nippon Veterinary and Life Science University
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ISHIOKA Katsumi
Department of Veterinary Nursing and Technology, Nippon Veterinary and Life Science University
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SAEKI Kaori
Department of Veterinary Nursing & Technology, School of Veterinary Science, Nippon Veterinary and Life Science University, 1–7–1 Kyonancho, Musashino, Tokyo 180–8602, Japan
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MORI Akihiro
Department of Veterinary Nursing and Technology, Nippon Veterinary and Life Science University
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Oda Hitomi
Department of Chemistry, Faculty of Science, Kwansei Gakuin University
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