Radical Scavenging Activity and Inhibition of Macrophage NO Production by Fukinolic Acid, a Main Phenolic Constituent in Japanese Butterbur (Petasites japonicus)

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概要

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• Four phenolic compounds were isolated from Japanese butterbur (Petasites japonicus) by preparative RP-HPLC technique, and were identified as chlorogenic acid (CGA), fukinolic acid (FA), 3,5-dicaffeoyl quinic acid, and 3,4,5-tricaffeoyl quinic acid. Since the antioxidant activity of FA among these four compounds has not been reported in detail, we investigated the scavenging activity of FA against several active oxygens and radicals, compared with CGA, gallic acid (GA) and epigallocatechin gallate (EGCG), using ESR spectroscopy. The order of potency of scavenging superoxide anion, nitric oxide (NO) and DPPH was EGCG>FA>CGA. The order of potency of scavenging hydroxyl radical was EGCG>FA>GA. FA inhibited the lipopolysaccharide-stimulated NO production and inducible NO synthase protein and mRNA expression by mouse macrophage-like cells Raw 264.7 more potently than CGA. The present study suggests the usefulness of FA as an antioxidant.

• 社団法人　日本食品科学工学会の論文
• 2007-11-01

著者

• WATANABE Satoru

  Department of Biocybernetics, Niigata University

• Iwamoto Yuzuri

  Agricultural Food And Environmental Sciences Research Center Of Osaka Prefecture

• Iwamoto Yuzuri

  Research Institute Of Environment Agriculture And Fisheries Osaka Prefectural Government

• Hashimoto Ken

  Division of Pharmacology,Department of Diagnostic and Therapeutic Sciences,Meikai University School

• Tazaki Hiroyuki

  Department of Veterinary and Animal Science ,Nippon Veterinary and Life Science University

• Shinohara Naoko

  Department of Health and Nutritional Sciences,Tokyo Seiei College

• Satoh Kazue

  Department of Anatomy, School of Medicine,Showa University

• SAKAGAMI Hiroshi

  Division of Pharmacology, Department of Diagnostic and Therapeutic Sciences, Meikai University Schoo

• Shinohara Naoko

  Department Of Health And Nutritional Sciences Tokyo Seiei College

• Tazaki Hiroyuki

  Department Of Veterinary And Animal Science Nippon Veterinary And Life Science University

• Sakagami Hiroshi

  Division Of Pharmacology Department Of Diagnostic And Therapeutic Sciences Meikai University

• Satoh Kazue

  Depatment Of Anatomy School Of Medicine Showa University

• Satoh Kazue

  昭和大学薬学部

• Watanabe Satoru

  Tokyo Seiei College

• 齋藤 節生

  Division Of Pharmacology Department Of Diagnostic And Therapeutic Sciences Meikai University

• Sakagami Hiroshi

  Division Of Pharmacology

• 斎藤 節生

  城西大学薬学部

• Tazaki Hiroyuki

  Department Of Bioresource Chemistry Obihiro University Of Agriculture And Veterinary Medicine

• Satoh Kazue

  Department Of Anatomy School Of Medicine

• Sakagami Hiroshi

  Division Of Dental Pharmacology Department Of Diagnostic And Therapeutic Sciences Meikai University

• Sakagami Hiroshi

  Division Of Pharmacology Department Of Diagnostic And Therapeutic Sciences Meikai University School

• Hashimoto Ken

  Division Of Pharmacology Department Of Diagnostic And Therapeutic Sciences Meikai University School

• Watanabe Satoru

  Department Of Biocybernetics Niigata University

• Watanabe Satoru

  Department Of Astronomy School Of Science The University Of Tokyo

• Hashimoto Ken

  Division Of Cardiology National Hospital Organization Okayama Medical Center

• TAZAKI Hiroyuki

  Department of Agricultural Chemistry, Faculty of Agriculture, Hokkaido University

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