Phenotypes of IRS-2 Deficient Mice Produced by Reproductive Technology are Stable

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概要

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• We studied the impact of "IVF - ET" on the glucose tolerance test (GTT), insulin tolerance test (ITT) and adiponectin to investigate differences in the phenotypes of B6J- Irs2-/- mice. The B6J-Irs2-/- mice (KO-Nat group) were prepared by natural mating. Other mice were produced by IVF-ET used ICR strain recipients and surrogate mothers (KO-IVF group). Measurement of body weight, GTT, ITT and blood sampling were performed at the ages of 6, 14 and 24 weeks after birth. Body weights, impaired glucose tolerance, insulin resistance and plasma adiponectin concentrations did not differ for each gender between the KO-IVF and KO-Nat groups. Therefore, we concluded that phenotypes of Irs2-/- mice produced by reproductive technology are stable.

• 社団法人　日本実験動物学会の論文

著者

• Kadowaki Takashi

  Department of Health Science, Shiga University of Medical Science

• YAMAUCHI Toshimasa

  Department of Metabolic Diseases, The University of Tokyo

• Tobe Kazuyuki

  Department of Metabolic Diseases, The University of Tokyo

• Oishi Yumiko

  Department Of Cardiology The University Of Tokyo

• ITO Mamoru

  Central Institute for Experimental Animals

• UEYAMA Yoshito

  Department of Pathology, School of Medicine, Tokai University

• Kadowaki Takashi

  Department Of Cardiovascular Medicine Graduate School Of Medicine University Of Tokyo

• Hioki Kyoji

  Central Inst. For Experimental Animals

• Ohishi Yumiko

  東京大学 医学系研究科循環器内科

• 高倉 彰

  財団法人実験動物中央研究所

• Takakura Akira

  実験動物中央研究所 Iclasモニタリングセンター

• Suzuki Ryo

  Department of Metabolic Diseases, Graduate School of Medicine, University of Tokyo

• HASHIMOTO Haruo

  Central Institute for Experimental Animals

• OHNISHI Yasuyuki

  Central Institute for Experimental Animals

• Ohsugi Mitsuru

  Department of Diabetes and Metabolism, University of Tokyo

• Ueyama Yoshito

  Department Of Pathology School Of Medicine Tokai University

• TAMAOKI Norikazu

  Central Institute for Experimental Animals

• ARAI Toshiro

  Department of Veterinary Biochemistry, Faculty of Veterinary Medicine, Nippon Veterinary and Animal

• SAITO Muneo

  Central Institute for Experimental Animals

• KOSAKA Kinori

  Central Institute for Experimental Animals

• Hashimoto Haruo

  Central Inst. For Experimental Animals

• ETO Tomoo

  Central Institute for Experimental Animals

• Yamauchi Toshimasa

  Department Of Integrated Molecular Science On Metabolic Disease 22nd Century Medical And Research Ce

• Arai Toshiro

  Department Of Veterinary Biochemistry

• Ohsugi Mitsuru

  Department Of Diabetes And Metabolism University Of Tokyo

• Tamaoki Norikazu

  Central Inst. For Experimental Animals

• Ohnishi Yasuyuki

  Central Inst. For Experimental Animals

• Suzuki Ryo

  Department Of Cardiovascular Surgery Tokyo Dental College Ichikawa General Hospital

• Arai T

  Dep. Of Veterinary Biochemistry Fac. Of Veterinary Medicine Nippon Veterinary And Animal Sci. Univ.

• Tobe Kazuyuki

  Department Of Metabolic Diseases University Of Tokyo

• Ito Mamoru

  Central Inst. For Experimental Animals Kawasaki Jpn

• Tobe Kazuyuki

  Department Of Metabolic Diseases

• Suzuki Ryo

  Department Of Biological And Chemical Engineering Gunma University

• Tobe Kazuyuki

  Department Of Internal Medicine (1) University Of Toyama

• Kadowaki Takashi

  Department Of Cardiology Kawasaki Medical School

• UEYAMA Yoshito

  Department of Dermatology, Division of Specialized Clinical Science, Tokai University School of Medicine

• UEYAMA Yoshito

  Department of Pathology, Tokai University School of Medicine

• OHSUGI Mitsuru

  Department of Metabolic Diseases, Graduate School of Medicine, The University of Tokyo

• KADOWAKI Takashi

  Department of Metabolic Diseases, Graduate School of Medicine, The University of Tokyo

• YAMAUCHI Toshimasa

  Department of Metabolic Diseases, Graduate School of Medicine, The University of Tokyo

• TOBE Kazuyuki

  Department of Metabolic Diseases, Graduate School of Medicine, The University of Tokyo

• SUZUKI Ryo

  Department of Metabolic Diseases, Graduate School of Medicine, The University of Tokyo

• ARAI Toshiro

  Department of Biochemistry, Nippon Veterinary and Animal Science University, 1-7-1 Kyonan-cho, Musashino-shi, Tokyo 180-8602, Japan

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