Chemotherapeutic Profiles of Human Tumors Implanted in SCID Mice Showing Appreciable Inconsistencies with Those in Nude Mice

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概要

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• Sensitivities to antitumor drugs of human tumor xenografts (HTXs) implanted in C.B-17-scid and in BALB/cA-nu were compared to examine whether genetic backgrounds of immune deficiency of the host mice influenced the chemotherapeutic profiles of implanted tumors. In a total of 25 pairs of corresponding experiments with each host mouse strain (5 HTXs × 5 drug treatment groups), we obtained consistent results in 23 (92.0%) experiments consisting of 10 which were both significantly effective and 13 which were both ineffective, although the remaining two (8.0%) experiments showed inconsistent results. A human T-cell lymphoma cell line, LM-2-JCK, implanted in nude mice, was resistant to treatment with 65 mg/kg of cyclophosphamide, but this tumor showed sensitivity to the same treatment when implanted in either SCID mice or mice with a recombination activating gene 2 defect [BALB/cA-TgH(Rag2)], suggesting that the genetic immune background of the host mouse should not be overlooked as a factor affecting tumors.

• 社団法人　日本実験動物学会の論文

著者

• Oishi Yumiko

  Department Of Cardiology The University Of Tokyo

• Hioki Kyoji

  Central Inst. For Experimental Animals

• Hioki K

  Central Inst. Experimental Animals Kanagawa

• Hioki K

  Central Inst. Of Experimental Animals Kawasaki Jpn

• Ohishi Yumiko

  東京大学 医学系研究科循環器内科

• Ueyama Y

  Dep. Of Pathology Tokai Univ. School Of Medicine

• Ueyama Y

  Tokai Univ. School Of Medicine Kanagawa Jpn

• Ueyama Y

  Tokai Univ. School Of Medicine Isehara‐shi Jpn

• Ueyama Yoshito

  Department Of Pathology Tokai University School Of Medicine

• OHNISHI Yasuyuki

  Central Institute for Experimental Animals

• YOSHIMURA Masumi

  Central Institute for Experimental Animals

• ENDO Sachio

  Central Institute for Experimental Animals

• UEYAMA Yoshito

  Central Institute for Experimental Animals, KAST Ueyama Project, Department of Pathology, Tokai Univ

• Ohnishi Yasuyuki

  Biomedical Research Department Central Institute For Experimental Animals

• Ohnishi Yasuyuki

  Central Inst. For Experimental Animals

• Umezawa Y

  Department Of Dermatology Tokai University School Of Medicine

• Yokosuka Makoto

  Dep. Of Veterinary Biochemistry Fac. Of Veterinary Medicine Nippon Veterinary And Animal Sci. Univ.

• Ueyama Yoshihito

  Department Of Pathology Tokai University School Of Medicine

• UEYAMA Yoshito

  Central Institute for Experimental Animals

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