HETEROTRANSPLANTATION OF HUMAN NEOPLASMS IN NUDE MICE

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概要

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• Heterotransplantation of human neoplastic tissue was investigated in the congenitally athymic mice, nude mice, BALB/c-nu/nu, kept in SPF condition within vinyl isolator.At present, 23 out of 32 established cell lines of various malignant neo plasm, originated from the lung, uterine cervix, endometrium, breast, cholan gioma, neuroblastoma, osteosarcoma and giant cell tumor have been success fully grafted in nude mice.Thirty six out of 162 surgically removed materials including carcinoma of the stomach, lung, kidney, maxilla, endometrium, uterine cervix, ovary, chorio carcinoma, meningioma and neuroblastoma have been transplanted in nude mice.The neoplasms serially transplanted in nude mice showed similar his tological characteristics of the primary tumors.Endocrine activities were also well preserved in nude mice, as revealed by the elevated blood HCG levels and histological changes in uterus and ovary of the host nude mice grafted with choriocarcinoma, and by erythropoiesis in the spleen of mice grafted with renal cell carcinoma which is producing erythropoietin. The grafted neoplasms showed similar susceptibility to anti cancer agents as originated one.

• The Keio Journal of Medicineの論文

著者

• Nomura Tatsuji

  Central Institute For Experimental Animals

• NOMURA TATSUJI

  Central Institute for Experimental Animals, Kawasaki

• UEYAMA YOSHITO

  Central Institute for Experimental Animals, Kawasaki

• UEYAMA Yoshito

  Central Institute for Experimental Animals

• OHSAWA NAKAAI

  The Third Department of Internal Medicine, Faculty of Medicine, University of Tokyo

• TAMAOKI NORIKAZU

  The Department of Pathology, School of Medicine, Tokai University

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