C57BL/6JJclを遺伝的背景に持つIRS2欠損マウスの効率的な繁殖方法の検討

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概要

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• Efficient reproduction using natural mating and reproduction technology [in vitro fertilization (IVF) and embryo transfer (ET)] was investigated in IRS2 deficient mice with C57BL/6JJcl genetic background (Irs2-/- mice) as a typical type 2 diabetes model. From the results using various combinations of Irs2-/- and Irs2-/+ mice, the combination of female Irs2-/+ × male Irs2-/- was found to be more efficient than other combinations. In applications of reproduction technology using IVF and ET, the combination of female Irs2-/+ × male Irs2-/- involves the possibility of Irs2-/- production by repeats using female Irs2-/+ mice. However, reproductive continuity using this combination is difficult because of dependence on human technique and the cost of ET. Therefore, we concluded that Irs2-/- mice should be produced by embryo transfer using Irs2-/- mice from a colony consisting of female Irs2-/+ × male Irs2-/-.

• 社団法人　日本実験動物学会の論文

著者

• 上迫 努

  財団法人実験動物中央研究所

• Kadowaki Takashi

  Department of Health Science, Shiga University of Medical Science

• 橋本 晴夫

  Central Institute for Experimental Animals

• YOKOSUKA Makoto

  Department of Comparative and Behavioral Medicine, Nippon Veterinary and Life Science University

• KUBOTA NAOTO

  Department of Diabetes and Metabolic Disease, Graduate School of Medicine, University of Tokyo

• YAMAUCHI Toshimasa

  Department of Metabolic Diseases, The University of Tokyo

• Tobe Kazuyuki

  Department of Metabolic Diseases, The University of Tokyo

• 江藤 智生

  Central Institute for Experimental Animals

• KAMISAKO Tsutomu

  Central Institute for Experimental Animals

• ITO Mamoru

  Central Institute for Experimental Animals

• Kamisako Tsutomu

  Central Inst. For Experimental Animals

• Kadowaki Takashi

  Department Of Cardiovascular Medicine Graduate School Of Medicine University Of Tokyo

• Hioki Kyoji

  Central Inst. For Experimental Animals

• Kubota Naoto

  Department Of Diabetes And Metabolic Disease Graduate School Of Medicine University Of Tokyo

• Nomura Tatsuji

  Central Institute For Experimental Animals

• Suzuki Ryo

  Department of Metabolic Diseases, Graduate School of Medicine, University of Tokyo

• HASHIMOTO Haruo

  Central Institute for Experimental Animals

• OHNISHI Yasuyuki

  Central Institute for Experimental Animals

• Ohsugi Mitsuru

  Department of Diabetes and Metabolism, University of Tokyo

• UEYAMA Yoshito

  Central Institute for Experimental Animals, KAST Ueyama Project, Department of Pathology, Tokai Univ

• TAMAOKI Norikazu

  Central Institute for Experimental Animals

• 上迫 努

  Central Institute for Experimental Animals

• HOYA Naoko

  Central Institute for Experimental Animals

• HATAKEYAMA Teruhiko

  Central Institute for Experimental Animals

• ARAI Toshiro

  Department of Veterinary Biochemistry, Faculty of Veterinary Medicine, Nippon Veterinary and Animal

• SAITO Muneo

  Central Institute for Experimental Animals

• KOSAKA Kinori

  Central Institute for Experimental Animals

• Hashimoto Haruo

  Central Inst. For Experimental Animals

• Yokosuka Makoto

  Department Of Anatomy And Embryology Tokyo Metropolitan Institute For Neuroscience

• ETO Tomoo

  Central Institute for Experimental Animals

• Yamauchi Toshimasa

  Department Of Integrated Molecular Science On Metabolic Disease 22nd Century Medical And Research Ce

• Hoya Naoko

  Central Inst. For Experimental Animals

• Arai Toshiro

  Department Of Veterinary Biochemistry

• Ohsugi Mitsuru

  Department Of Diabetes And Metabolism University Of Tokyo

• Tamaoki Norikazu

  Central Inst. For Experimental Animals

• Ohnishi Yasuyuki

  Central Inst. For Experimental Animals

• Suzuki Ryo

  Department Of Cardiovascular Surgery Tokyo Dental College Ichikawa General Hospital

• Tobe Kazuyuki

  Department Of Metabolic Diseases University Of Tokyo

• Ito Mamoru

  Central Inst. For Experimental Animals Kawasaki Jpn

• Tobe Kazuyuki

  Department Of Metabolic Diseases

• Suzuki Ryo

  Department Of Biological And Chemical Engineering Gunma University

• Tobe Kazuyuki

  Department Of Internal Medicine (1) University Of Toyama

• Kadowaki Takashi

  Department Of Cardiology Kawasaki Medical School

• UEYAMA Yoshito

  Central Institute for Experimental Animals

• YOKOSUKA Makoto

  Department of Veterinary Biochemistry, Faculty of Veterinary Medicine, Nippon Veterinary and Animal Science University

• ARAI Toshiro

  Department of Veterinary Biochemistry, Faculty of Veterinary Medicine, Nippon Veterinary and Animal Science University

• ARAI Toshiro

  Department of Biochemistry, Nippon Veterinary and Animal Science University, 1-7-1 Kyonan-cho, Musashino-shi, Tokyo 180-8602, Japan

• TOBE Kazuyuki

  Department of Metabolic Diseases, Graduate School of Medicine, University of Tokyo

• KUBOTA Naoto

  Department of Metabolic Diseases, Graduate School of Medicine, University of Tokyo

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