Lack of B Cell Leakiness in BALB/cA-nu, scid Double Mutant Mice

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概要

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• BALB/cA mice homozygous for both nu and scid mutations (BALB/cA-nu/nu, scid/scid) were developed by mating between BALB/cA-scid and BALB/cA-nu. These mice have greater longevity than C.B-17-scid because no thymic lymphoma occurs in them unlike in the latter. C.B-17-scid is known to show the leaky phenomenon in which a few clones of functional T and B cells develop in aged C.B-17-scid. Unexpectedly, the leaky B cells and T cells were absent or suppressed in BALB/cA-nu, scid mice when cytokine expressions were determined by RT-PCR, lymphocyte phenotypes by flow cytometry and serum immunoglobulin levels by ELISA. These results indicate that B cell leakiness may be induced by leaked T cells. BALB/cA-nu, scid mice may be useful as a recipient in allo- and xeno-transplantation experiments because of the absence of both thymic lymphomas and leakiness, in addition to lack of hair.

• 社団法人　日本実験動物学会の論文

著者

• Kadowaki T

  Department Of Translational Research For Healthcare And Clinical Science University Of Tokyo

• ITO Mamoru

  Central Institute for Experimental Animals

• UEYAMA Yoshito

  Department of Pathology, School of Medicine, Tokai University

• Kadowaki Takashi

  Department Of Cardiovascular Medicine Graduate School Of Medicine University Of Tokyo

• Kohro Takahide

  Department Of Translational Research For Healthcare And Clinical Science University Of Tokyo

• Hioki Kyoji

  Central Inst. For Experimental Animals

• Hioki K

  Central Inst. Experimental Animals Kanagawa

• Hioki K

  Central Inst. Of Experimental Animals Kawasaki Jpn

• Ueyama Y

  Dep. Of Pathology Tokai Univ. School Of Medicine

• Ueyama Y

  Tokai Univ. School Of Medicine Kanagawa Jpn

• Ueyama Yoshito

  Department Of Pathology Tokai University School Of Medicine

• Ueyama Yoshito

  Department Of Pathology School Of Medicine Tokai University

• Kohro Takahide

  Department Of Translational Research For Health Care And Clinical Science Graduate School Of Medicin

• KURAMOCHI Takashi

  Central Institute for Experimental Animals

• ENDOH Sachio

  Central Institute for Experimental Animals

• TERADA Ehji

  Department of Laboratory Animal Science, School of Physiology, Kitasato University

• Terada E

  Department Of Laboratory Animal Science School Of Physiology Kitasato University

• Ito M

  Central Inst. For Experimental Animals

• Umezawa Y

  Department Of Dermatology Tokai University School Of Medicine

• Terada Ehji

  Department Of Laboratory Animal Science School Of Physiology Kitasato University

• Kohro Takahide

  Department Of Cardiovascular Medicine Graduate School Of Medicine University Of Tokyo

• Kadowaki Takashi

  Department Of Human Genetics Graduate School Of Medicine University Of Tokyo

• Ito Mamoru

  Central Inst. For Experimental Animals Kawasaki Jpn

• Ueyama Yoshihito

  Department Of Pathology Tokai University School Of Medicine

• UEYAMA Yoshito

  Department of Dermatology, Division of Specialized Clinical Science, Tokai University School of Medicine

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