Elevated Serum Uric Acid is an Independent Predictor for Cardiovascular Events in Patients With Severe Coronary Artery Stenosis : Subanalysis of the Japanese Coronary Artery Disease (JCAD) Study
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概要
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Background: The association of elevated serum uric acid (UA) with cardiovascular events in patients with severe coronary artery stenosis was examined. Methods and Results: Patients with stenosis ≥75% (n=8,832) were followed for "all events" (cardiovascular events and all-cause mortality) for 3 years. The group was divided into quartiles based on baseline UA level. The incidence rate of all events was significantly different among quartiles (58.3, 56.5, 61.2, 76.3/1,000 patients-year, P<0.001). Coxs proportional hazard regression analysis showed that the hazard ratio (HR) for all events was 1.25 [95% confidence interval (CI): 1.07-1.45, P<0.01] in the highest quartile (UA ≥6.8 mg/dl). The group in which UA increased ≥1.0 mg/dl after 6 months had significantly higher cardiovascular events rate than the group in which UA did not change (70.6 vs 58.8/1,000 patients-year, P=0.042). Propensity score matching was performed and 4,206 patients were divided into the highest quartile and the rest. High UA remained an independent predictor of all events (HR 1.25, 95%CI 1.06-1.43). However, no significant difference was observed between the group with increased UA ≥1.0 mg/dl and the group with unchanged UA level. Conclusions: Elevated UA is an independent predictor of cardiovascular events and all-cause mortality combined in patients with coronary artery stenosis.
- 社団法人 日本循環器学会の論文
- 2009-04-20
著者
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NAGAI Ryozo
Department of Cardiovascular Medicine, University of Tokyo
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荻原 俊男
Division Of Preventive Cardiology National Cardiovascular Center
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HIGAKI Jitsuo
Ehime University
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HIGAKI Jitsuo
Department of Integrated Medicine and Informatics, Ehime University Medical School
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Tochikubo Osamu
横浜市立大学 第2内科
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Ohkubo T
Department Of Planning For Drug Development And Clinical Evaluation Tohoku University
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Nagai R
Department Of Cardiology The University Of Tokyo
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Nagai Ryozo
東京大学 心臓外科学
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Nagai Ryouzou
Department Of Cardiovascular Medicine Graduate School Medicine University Of Tokyo
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Yamazaki Tsutoinu
Department Of Clinical Epidemiology And Systems University Of Tokyo
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Yamazaki Tsutomu
Department of Clinical Epidemiology & Systems, The University of Tokyo
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Ohkubo Takayoshi
東北大学 臨床薬学
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Kohro Takahide
Department of Translational Research for Healthcare and Clinical Science, The University of Tokyo
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Kadowaki T
Department Of Translational Research For Healthcare And Clinical Science University Of Tokyo
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Kohro Takahide
獨協医科大学 循環器内科
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Kohro Takahide
Department Of Cardiology Tokyo University School Of Medicine
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Hayashi Doubun
Department Of Translational Research For Health Care And Clinical Science Graduate School Of Medicin
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OKURA Takafumi
Department of Integrated Medicine and Informatics, Ehime University Graduate School of Medicine
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KURATA Mie
Department of Integrated Medicine and Informatics, Ehime University Graduate School of Medicine
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IRITA Jun
Department of Integrated Medicine and Informatics, Ehime University Graduate School of Medicine
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MIYOSHI Ken-ichi
Department of Integrated Medicine and Informatics, Ehime University Graduate School of Medicine
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Kurata Mie
Department Of Integrated Medicine And Informatics Ehime University Graduate School Of Medicine
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Kurata Mie
愛媛大学 医学系研究科病態情報内科学
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Irita Jun
Department Of Integrated Medicine And Informatics Ehime University Graduate School Of Medicine
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Okura Takafumi
Department Of Integrated Medicine And Informatics Ehime University Graduate School Of Medicine
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Miyoshi Ken-ichi
Department Of Integrated Medicine And Informatics Ehime University Graduate School Of Medicine
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Miyoshi Ken-ichi
愛媛大学 医学系研究科病態情報内科学
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Ohtsuka Tomoaki
愛媛大学 医学系研究科臨床看護学
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Kadowaki Takashi
東京大学 医学系研究科代謝栄養病態学
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Kadowaki Takashi
Department Of Cardiovascular Medicine Graduate School Of Medicine University Of Tokyo
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Kohro Takahide
Department Of Translational Research For Healthcare And Clinical Science University Of Tokyo
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Okuda Tomohiko
Research Institute National Cardiovascular Center
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Higaki Jitsuro
The Department Of Geriatric Medicine Osaka University Medical School
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Okuda Tomohiro
Research Institute National Cardiovascular Center
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Ojima Toshiyuki
Hamamatsu Univ. School Of Medicine
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Okubo Takayoshi
Department Of Planning For Drug Development And Clinical Evaluation Tohoku University
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Nagai R
Department Of Cardiovascular Medicine The University Of Tokyo
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Kadowaki Takashi
Department Of Metabolic Diseases The University Of Tokyo
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Higaki Jitsuo
The Second Department Of Internal Medicine Ehime University School Of Medicine
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Kohro Takahide
Department Of Translational Research For Healthcare And Clinical Science
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Kohro Takahide
Department Of Translational Research For Health Care And Clinical Science Graduate School Of Medicin
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Nagai Ryozo
Department Of Cardiovascular Medicine Graduate School Of Medicine University Of Tokyo
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Tochikubo Osamu
The Second Department Of Internal Medicine Yokohama City University
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Higaki Jitsuo
Department Of Medicine And Geriatrics Osaka University Medical School
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Higaki Jitsuo
Second Department Of Internal Medicine Ehime University School Of Medicine
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Okura Takafumi
Department Of Planning For Drug Development And Clinical Evaluation Tohoku University
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Higaki Jitsuo
Department Of Geriatric Medicine Osaka University Medical School
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Okamura Tomonori
Department Of Health Science Shiga University Of Medical Science
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Nagai Ryouzou
The Department Of Cardiovascular Diseases Graduate School Of Medicine University Of Tokyo
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Ohtsuka Tomoaki
Department Of Integrated Medicine And Informatics Ehime University Graduate School Of Medicine
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Higaki Jitsuo
Department Of Internal Medicine Ehime University School Of Medicine
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Ohtsuki Taisuke
Nervous And Muscular Disorders National Center For Neurology And Psychiatry
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Ogihara T
Osaka Univ. Medical School Osaka Jpn
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Yamazaki Tsutomu
Department Of Applied Chemistry Tokyo University Of Agriculture And Technology
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Nagai Ryouzou
Department Of Cardiovascular Medicine The School Of Medicine The University Of Tokyo
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Kadowaki Takashi
Department Of Endocrinology And Metabolism The University Of Tokyo
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Kohro Takahide
Department Of Cardiovascular Medicine Graduate School Of Medicine University Of Tokyo
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Hayashi Doubun
Department Of Cardiovascular Medicine The University Of Tokyo
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Kadowaki Takashi
Department Of Human Genetics Graduate School Of Medicine University Of Tokyo
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Nagai Ryozo
Department Of Cardiology Kitano Hospital Medical Research Institute
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Nagai Ryouzou
Department Of Cardiovascular Medicine University Of Tokyo Graduate School Of Medicine
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Yamazaki Tsutomu
Department Of Clinical Epidemiology And Systems University Of Tokyo
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Higaki Jitsuo
Department Of Ehime University Graduate School Of Medicine
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Yamazaki Tsutomu
Department Of Clinical Epidemiology & Systems The University Of Tokyo
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Nagai Riozo
Second Department Of Internal Medicine Gunma Univercity School Of Medicine
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Ogihara Toshio
The Department Of Medicine And Clinical Science Graduate School Of Medical Sciences Kyushu Universit
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Yamazaki Tsutomu
Department Of Applied Chemistry Graduate School Of Engineering Tokyo University Of Agriculture And T
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Nagai Ryozo
Department Of Cardiovascular Medicine Graduate School Of Medicine Faculty Of Medicine The University
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Nagai Ryozo
Department Cardiovascular Medicine The University Of Tokyo Hospital
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Higaki Jitsuo
Division Of Cardiology Department Of Integrated Medicine And Informatics Ehime University Graduate S
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Higaki Jitsuo
Second Department Of Internal Medicine Ehime University Medical School
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Yamazaki Tsutomu
Department Of Clinical Epidemiology And Systems University Of Tokyo Graduate School Of Medicine
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Hayashi Doubun
Department Of Cardiovascular Medicine Graduate School Of Medicine University Of Tokyo
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Hayashi Dobun
Healthcare Center Nippon Yusen Kaisya
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Higaki Jitsuo
Department of Cardiology, Pulmonology, Hypertension & Nephrology, Ehime University Graduate School of Medicine, Japan
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