A New Therapeutic Strategy for Hypertrophic Nonobstructive Cardiomyopathy in Humans : A Randomized and Prospective Study With an Angiotensin II Receptor Blocker
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概要
- 論文の詳細を見る
A randomized and prospective study was designed to prove the efficacy of angiotensin II receptor blockers (ARB) in the amelioration of myocardial impairment in hypertrophic nonobstructive cardiomyopathy (HNCM). Nineteen consecutive patients with HNCM were randomly assigned to two groups and then underwent cine magnetic resonance evaluation of left ventricular mass (LVM) twice just before and after one year of observation. In the ARB group, 50 mg of losartan potassium was administered once daily during the observation period. The ratio of LVM after the observation period over that before the period was blindly compared between the two groups to estimate morphologically the ameliorative effect of ARB. In the ARB group, LVM was 203 ± 47 cm3 before the treatment period and 190 ± 55 cm3 after the period and the ratio of the final LVM over the initial LVM was 0.93 ± 0.10. In the non-ARB group the initial and final LVM values were 177 ± 48 cm3 and 179 ± 45 cm3, and the ratio of the final LVM over the initial LVM was 1.02 ± 0.07. The ratio of the final LVM over the initial LVM in the ARB group was significantly smaller (P = 0.03) than that in the non-ARB group. The smaller ratio in the ARB group strongly indicates that ARB ameliorated the natural course of HNCM during the one year observation period. Thus, this is the first demonstration of the therapeutic efficacy of ARB in human HNCM.
- インターナショナル・ハート・ジャーナル刊行会の論文
著者
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SUZUKI Jun-ichi
Department of Advanced Clinical Science and Therapeutics, University of Tokyo
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NAGAI Ryozo
Department of Cardiovascular Medicine, University of Tokyo
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Yamazaki Tadashi
Department of Cardiovascular Medicine, University of Tokyo
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Yamazaki Tadashi
東京大学 医学系研究科循環器内科
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Shimamoto Ryoichi
Departments of Cardiovascular, Faculty of Medicine and Graduate School of Medicine, Medicine, Univer
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Tsuji Taeko
Departments of Cardiovascular, Faculty of Medicine and Graduate School of Medicine, Medicine, Univer
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Ohmoto-Sekine Yuki
Departments of Cardiovascular, Faculty of Medicine and Graduate School of Medicine, Medicine, Univer
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Ohtomo Kuni
Departments of Radiology, Faculty of Medicine and Graduate School of Medicine, University of Tokyo
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Shimamoto Ryoichi
Department Of Cardiovascular Medicine University Of Tokyo
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Tsuji Taeko
Department Of Cardiovascular Medicine University Of Tokyo
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Ohtomo Kuni
Department Of Radiology Faculty Of Medicin University Of Tokyo
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Suzuki Jun-ichi
Department Of Advanced Clinical Science And Therapeutics Graduate School Of Medicine University Of T
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Yamazaki Tadashi
Department Of Cardiovascular Medicine University Of Tokyo
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Nagai Ryozo
Department Cardiovascular Medicine The University Of Tokyo Hospital
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Ohmoto-Sekine Yuki
Departments of Cardiovascular, Faculty of Medicine and Graduate School of Medicine, Medicine, University of Tokyo
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Tsuji Taeko
Departments of Cardiovascular, Faculty of Medicine and Graduate School of Medicine, Medicine, University of Tokyo
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Shimamoto Ryoichi
Departments of Cardiovascular, Faculty of Medicine and Graduate School of Medicine, Medicine, University of Tokyo
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Yamazaki Tadashi
Departments of Cardiovascular, Faculty of Medicine and Graduate School of Medicine, Medicine, University of Tokyo
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