Intracoronary Serum Smooth Muscle Myosin Heavy Chain Levels Following PTCA may Predict Restenosis
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概要
- 論文の詳細を見る
Recently a novel biochemical method that uses an immunoassay to quantitate serum smooth muscle myosin heavy chain (SMMHC) levels was developed for diagnosis of aortic dissection.1) The purpose of this study was to determine whether SMMHC released from the coronary arterial wall can be used to predict restenosis after percutaneous transluminal coronary angioplasty (PTCA). Fifty-two consecutive patients undergoing successful PTCA for single vessel disease were examined (40 men, 12 women, 63±8 years). Intracoronary blood samples were obtained distal to the lesion, and from the femoral artery after PTCA. In 10 patients, blood samples were taken immediately after the final balloon inflation, and 10 and 20 minutes after PTCA. SMMHC levels were measured by ELISA using SMMHC-specific monoclonal antibodies. Follow-up coronary angiography was performed 3 months after PTCA. Intracoronary serum SMMHC levels were significantly higher than those obtained from the femoral artery (10.6±1.5 vs 2.1±0.1 ng/ ml, p≤0.001). Of 40 patients without apparent dissection, the 23 patients who did not develop restenosis in the follow-up study were found to have had higher levels of intracoronary SMMHC levels immediately after PTCA compared to the 17 patients with restenosis (15.2±2.9 vs 7.1±1.2 ng/ml, p≤0.05). We suggest that elevated intracoronary SMMHC levels after PTCA may reflect the extent of injury to the arterial wall. Intracoronary SMMHC may be a possible biochemical marker for the prediction of restenosis. (Jpn Heart J 2000; 41: 131-140)
- Japanese Heart Journal Associationの論文
著者
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NAGAI Ryozo
Department of Cardiovascular Medicine, University of Tokyo
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HASEGAWA Akira
The Second Department of Internal Medicine,Gunma University School of Medicine
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Nogami Akihiko
Cardiology Division, Yokohama Rosai Hospital
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Suzuki Toru
Department Of Ubiquitous Preventive Medicine Graduate School Of Medicine The University Of Tokyo
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Kurabayashi Masahiko
群馬大学 医学系研究科臓器病態内科学
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KURABAYASHI Masahiko
The Second Department of Internal Medicine, Gunma University School of Medicine
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Nagai Ryozo
武蔵野赤十字病院
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Hoshizaki Hiroshi
Cardiology Division, Gunma Prefectural Carotovascular Center
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Taniguchi Koichi
Cardiology Division, Gunma Prefectural Carotovascular Center
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TSUCHIO Yasuhiro
Cardiology Division, Gunma Prefectural Cardiovascular Center, Maebashi, Japan.
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NAITO Shigeto
Cardiology Division, Gunma Prefectural Cardiovascular Center, Maebashi, Japan.
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OSHIMA Shigeru
Cardiology Division, Gunma Prefectural Cardiovascular Center, Maebashi, Japan.
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KATOH Hirohisa
Immunology Laboratory, Diagnostics Division, Yamasa Corporation, Chiba, Japan.
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Nogami Akihiko
Cardiology Division Yokohama Rosai Hospital
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Hasegawa Akira
The Second Department Of Internal Medicine And The Department Of Hygiene Gunma University School Of
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Nagai Ryozo
Department Cardiovascular Medicine The University Of Tokyo Hospital
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Taniguchi Koichi
Cardiology Division Gunma Prefectural Cardiovascular Center
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Naito Shigeto
Cardiology Division Gunma Cardiovascular Center
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Suzuki Toru
Department of Applied Electronics, Faculty of Industrial Science and Technology, Tokyo University of Science, 2641 Yamazaki, Noda, Chiba 278-8510, Japan
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NOGAMI Akihiko
Cardiology Division, Gunma Prefectural Cardiovascular Center, Maebashi, Japan.
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Hoshizaki Hiroshi
Cardiology Division, Gunma Prefectural Cardiovascular Center
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HOSHIZAKI Hiroshi
Cardiology Division, Gunma Prefectural Cardiovascular Center, Maebashi, Japan.
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TANIGUCHI Koichi
Cardiology Division, Gunma Prefectural Cardiovascular Center, Maebashi, Japan.
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