Upregulated Neurohumoral Factors are Associated With Left Ventricular Remodeling and Poor Prognosis in Rats With Monocrotaline-Induced Pulmonary Arterial Hypertension
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概要
- 論文の詳細を見る
Background Left ventricular remodeling might be involved in the pathophysiology of right ventricular hypertrophy/failure due to pulmonary arterial hypertension (PAH), while the left ventricle is considered not under pressure/volume overload. Methods and Results Rats with monocrotaline-induced PAH were used in the present study to examine whether upregulated neurohumoral factors may induce left ventricular (LV) remodeling and (/or) contribute to prognosis. Morphological analysis revealed a significant increase in the weight of the free walls of both ventricles and the interventricular septum, indicating biventricular hypertrophy, although systemic blood pressure was not elevated. RNase protection assay demonstrated the activation of a fetal gene program in the cardiac muscle of the left and right ventricular free walls. Similar activation of the fetal gene program was observed in the LV of rats continuously infused with angiotensin (AT) II, although this was not the case for rats infused with isoproterenol. Measured plasma levels of ATII, noradrenaline, and brain natriuretic peptide (BNP) were all significantly elevated in the PAH rats. Furthermore, the plasma BNP level positively correlated with the ratio of heart weight to body weight and the plasma level of ATII. Not right but LV hypertrophy was significantly reduced by treatment with an AT II type 1 receptor blocker, valsartan, whereas the effect of an adrenergic αi and β1,2 blocker, carvedilol, was borderline. Survival rate in the PAH rats was significantly improved when they were treated with valsartan or carvedilol. Conclusions Upregulated neurohumoral factors seem to play an important role in LV remodeling without mechanical overload, and are associated with impairment of prognosis in rats with PAH.
- 社団法人日本循環器学会の論文
- 2006-08-20
著者
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NAGAI Ryozo
Department of Cardiovascular Medicine, University of Tokyo
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Usui Shin-ichi
Department of Cardiology, JR Tokyo General Hospital
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Takahashi Toshiyuki
Department of Cardiology, JR Tokyo General Hospital
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Takihara Keiko
Tokyo Medical University
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Takahashi Toshiyuki
Department Of Cardiovascular Medicine Graduate School Of Medicine University Of Tokyo
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Usui Shin-ichi
Department Of Cardiovascular Medicine Graduate School Of Medicine University Of Tokyo
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Kitamura Kazuo
Department Of Geriatric Medicine Ehime University Graduate School Of Medicine
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Yao Atsushi
Department of Cardiovascular Medicine, University of Tokyo Graduate School of Medicine
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Hatano Masaru
Department of Cardiovascular Medicine, Graduate School of Medicine, University of Tokyo
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Kohmoto Osami
The Second Department of Medicine, Saitama Medical School
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Kinugawa Koichiro
Department of Cardiovascular Medicine, Graduate School of Medicine, University of Tokyo
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Kinugawa Koh-ichiro
Department Of Cardiovascular Medicine Graduate School Of Medicine The University Of Tokyo
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Kohmoto Osami
The Second Department Of Medicine Saitama Medical School
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Yao Atsushi
Department Of Cardiovascular Medicine Graduate School Of Medicine The University Of Tokyo
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Yao Atsushi
Department Of Cardiovascular Medicine Graduate School Of Medicine University Of Tokyo
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Kohmoto Osami
The Second Department Of Internal Medicine Faculty Of Medicine University Of Tokyo
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Takahashi Tomiko
Department Of Cardiovascular Medicine University Of Tokyo
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Kinugawa Koichiro
Department Of Cardiovascular Medicine University Of Tokyo Graduate School Of Medicine
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Takahashi Toshiyuki
Department Of Cardiovascular Medicine University Of Tokyo Graduate School Of Medicine
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Kangawa Kenji
Department Of Cardiovascular Medicine Graduate School Of Medicine The University Of Tokyo
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Yao Atsushi
Department Of Cardiovascular Medicine The University Of Tokyo Hospital
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Hatano Masaru
Department Of Cardiovascular Medicine Graduate School Of Medicine The University Of Tokyo
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Hatano Masaru
Department Of Cardiology Narita Red Cross Hospital
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Nagai Ryouzou
The Department Of Cardiovascular Diseases Graduate School Of Medicine University Of Tokyo
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Takahashi Tomiko
Department Of Laboratory Medicine University Of Tokyo
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Takahashi Toshiyuki
Department Of Biology Keio University
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Takahashi Toshiyuki
Department Of Cardiovascular Medicine University Of Tokyo
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Toshimori Tsukasa
2nd Dept. Of Biochem. Miyazaki Med. Coll.
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Kinugawa Koichiro
Department Of Cardiovascular Medicine Graduate School Of Medicine University Of Tokyo
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Nagai Ryozo
Department Of Cardiology Kitano Hospital Medical Research Institute
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Hatano Masaru
Department Of Cardiovascular Medicine Graduate School Of Medicine University Of Tokyo
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Yao Atsushi
Department Of Cardiology Tokyo University Hospital
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Takahashi Toshiyuki
Department Of Biological Science Graduate School Of Science Hiroshima University
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Nagai Ryozo
Department Cardiovascular Medicine The University Of Tokyo Hospital
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Takahashi Toshiyuki
The 2nd Department Of Internal Medicine University Of Tokyo
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Takahashi Toshiyuki
Department Of Cardiovascular Medicine Tokyo Graduate School Of Medicine
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Takahashi Toshiyuki
Department Of Dermatology Faculty Of Medicine University Of Tokyo
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Kimura Koichi
Department Of Cardiovascular Medicine University Of Tokyo
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Inaba Toshiro
Department Of Cardiovascular Medicine Graduate School Of Medicine University Of Tokyo
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Kinugawa Koh-ichiro
Department of Cardiovascular Medicine, University of Tokyo Graduate School of Medicine
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Takahashi Toshiyuki
Department of Applied Chemistry, Faculty of Science and Engineering, Kinki University
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