Focalized Contractile Impairment at Hypertrophied Myocardium Proven in Consideration of Wall Stress in Patients With Hypertrophic Cardiomyopathy
スポンサーリンク
概要
- 論文の詳細を見る
In hypertrophic cardiomyopathy (HCM) a hyperkinetic state is sometimes observed in spite of impaired systolic function in the hypertrophied myocardium. The aim of the present study was to determine the mechanism of this paradox. Seventeen patients with HCM and 10 normal subjects underwent cine magnetic resonance (MR) imaging to measure percent systolic wall thickening and percent fractional shortening. The ratio of systolic radial wall stress of the LV at the hypertrophied myocardium over that at the nonhypertrophied myocardium was evaluated to describe the focal advantageous condition for wall thickening. The ratio was 0.66 ± 0.36 at the start of contraction and 0.78 ± 0.31 at early-systole, indicating consistently smaller radial wall stress at the hypertrophied myocardium. Although the condition for contraction was favorable (a ratio less than 1.00), percent systolic wall thickening at the hypertrophied myocardium (23.0 ± 11.8%) was smaller than that at the nonhypertrophied myocardium (70.5 ± 32.3%). Smaller end-diastolic dimension (HCM group; 45.2 ± 4.2 mm, reference group; 48.9 ± 4.1 mm, P = 0.04) with a statistically identical value of systolic decrease in intraventricular dimension (HCM group; 19.7 ± 3.9 mm, reference group; 18.9 ± 3.2 mm, P = 0.60) yielded high percent fractional shortening in patients with HCM (43.5 ± 7.6%). Although contractile impairment was proven at the hypertrophied region with low radial wall stress in the HCM group, the smaller end-diastolic dimension in this group resulted in high percent fractional shortening.
- インターナショナル・ハート・ジャーナル刊行会の論文
著者
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OMATA Masao
Department of Gastroenterology, Faculty of Medicine, University of Tokyo
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SUZUKI Jun-ichi
Department of Advanced Clinical Science and Therapeutics, University of Tokyo
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NAGAI Ryozo
Department of Cardiovascular Medicine, University of Tokyo
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Yamazaki Tadashi
Department of Cardiovascular Medicine, University of Tokyo
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Yamazaki Tadashi
東京大学 医学系研究科循環器内科
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Shimamoto Ryoichi
Departments of Cardiovascular, Faculty of Medicine and Graduate School of Medicine, Medicine, Univer
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Tsuji Taeko
Departments of Cardiovascular, Faculty of Medicine and Graduate School of Medicine, Medicine, Univer
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Ohtomo Kuni
Departments of Radiology, Faculty of Medicine and Graduate School of Medicine, University of Tokyo
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Ohmoto Yuki
Department of Internal Medicine, Graduate School of Medicine and Faculty of Medicine, The University
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Toyo-oka Teruhiko
Department of Internal Medicine, Graduate School of Medicine and Faculty of Medicine, The University
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Shimamoto Ryoichi
Department Of Cardiovascular Medicine University Of Tokyo
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Tsuji Taeko
Department Of Cardiovascular Medicine University Of Tokyo
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Omata Masao
Department Of Cardiology Narita Red Cross Hospital
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Toyo-oka Teruhiko
Department Of Cardiology Jichi Medical School
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Ohtomo Kuni
Department Of Radiology Faculty Of Medicin University Of Tokyo
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Suzuki Jun-ichi
Department Of Advanced Clinical Science And Therapeutics Graduate School Of Medicine University Of T
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Yamazaki Tadashi
Department Of Cardiovascular Medicine University Of Tokyo
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Nagai Ryozo
Department Cardiovascular Medicine The University Of Tokyo Hospital
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Ohmoto Yuki
Department of Internal Medicine, Graduate School of Medicine and Faculty of Medicine, The University of Tokyo
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Ohmoto Yuki
Department of Health Management Center, Toranomon Hospital, Japan
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Toyo-oka Teruhiko
Department of Internal Medicine, Graduate School of Medicine and Faculty of Medicine, The University of Tokyo
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Shimamoto Ryoichi
Department of Internal Medicine, Graduate School of Medicine and Faculty of Medicine, The University of Tokyo
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Yamazaki Tadashi
Department of Internal Medicine, Graduate School of Medicine and Faculty of Medicine, The University of Tokyo
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